Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123826 - 123826
Опубликована: Май 1, 2025
Язык: Английский
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101578 - 101578
Опубликована: Фев. 14, 2025
In diabetic wounds, the presence of hyperglycemia is often accompanied by a persistent inflammatory response, oxidative stress damage, impaired angiogenesis and bacterial infections around wound, resulting in proliferation dermal epidermal cells skin regeneration wounds. To solve above problems, this study designed near-infrared (NIR) light-responsive multifunctional poloxamer hydrogel (EGF/PDA-MXene Gel). The Gel composed two-dimensional nanomaterials (2D NMs) MXene as core, modified polymer, further loaded with growth factor (EGF), has antibacterial, antioxidant, photothermal properties. Meanwhile, EGF/PDA-MXene can be used drug repository, alleviating problem short half-life, realizing sustained release EGF. NIR property induces protein denaturation leading to death pathogenic bacteria, avoiding common clinical antibiotic resistance. addition, promotes chronic wound healing promoting regeneration, collagen deposition, angiogenesis, several other mechanisms. Therefore, preparation strategies that combine bioactive molecules 2D NMs, which maintains activity EGF while exploiting antimicrobial advantages NMs photothermally, provide new promising therapeutic approach for accelerating repair infected
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Фев. 20, 2025
Abstract Malignant bone tumor defects are difficult to treat because of the simultaneous need for treatment and bone‐repair promotion. This study presents a bioactive composite scaffold (T‐rGO@Au) personalized defect repair treatment. The T‐rGO@Au has porous structure, its mechanical properties close those human cancellous bone. can induce upregulation osteopontin (OPN), RUNX‐2, osteocalcin (OCN) gene expression. In vivo experiments showed that volume/total volume (BV/TV) ratio with was highest. new tightly integrated implant, demonstrating effective osseointegration. locally generated high temperatures reactive oxygen species under near‐infrared excitation, AuNPs enhanced photothermal performance rGO through “antenna effect.” Furthermore, in vitro cell nuclei were destroyed, late‐stage apoptotic cells increased, morphology severely damaged. Additionally, RNA‐seq revealed destruction mediated signaling pathways, such as MAPK pathway. antitumor also demonstrated significantly inhibited growth within 2 weeks. Thus, provides strategy development implantable scaffolds defects.
Язык: Английский
Процитировано
0
Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)
Опубликована: Март 4, 2025
Graphdiyne (GDY), the sole synthetic carbon allotrope with sp-hybridized atoms, has been extensively researched that benefit from its pore structure, fully conjugated surfaces, wide band gaps, and more reactive C≡C bonds. In addition to intrinsic features of GDY, engineering at nanoscale, including metal/transition metal ion modification, chemical elemental doping, other biomolecular modifications, endowed GDY a broader functionality. This led involvement in biomedical applications, enzyme catalysis, molecular assays, targeted drug delivery, antitumor, sensors. These promising research developments have made possible by rational design critical characterization biomaterials. contrast areas, biomaterials development techniques methods specific patterns some innovations based on integration materials science biology, which are crucial for applications GDY. The objective this review is provide comprehensive overview essential process. Additionally, general strategy will be proposed, limited help researchers field or nanomedicine.
Язык: Английский
Процитировано
0
Materials Chemistry and Physics, Год журнала: 2025, Номер unknown, С. 130650 - 130650
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Advanced Materials Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Апрель 15, 2025
Abstract Infectious bone defects represent a significant clinical challenge, characterized by prolonged treatment durations, high medical costs, propensity for recurrence, and risk of disability. This issue remains critical concern in the orthopedic field globally. The successful management infectious hinges on two primary aspects: reconstruction eradication infection. Synthetic repair materials can be broadly categorized into metallic materials, inorganic compounds, organic polymers, composite materials. While antibiotics address most bacterial infections, their efficacy treating infections is limited due to unique physiological anatomical characteristics tissue. Consequently, there an urgent need develop localized, non‐antibiotic antibacterial strategies. Incorporating components help establish antimicrobial microenvironment at defect sites, promoting effective regeneration. Currently, are frequently combined with organic, inorganic, stimuli‐responsive, multi‐modal agents. review aims provide overview commonly used integration agents, offering insights guide development next‐generation thereby addressing needs practice.
Язык: Английский
Процитировано
0
Carbohydrate Polymers, Год журнала: 2025, Номер unknown, С. 123826 - 123826
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0