Advanced Relationships Between Structure and Properties of Chitosan-Based Polymeric Hydrogels in Oncology and Their Impact on the Tumor Microenvironment DOI
Sankha Bhattacharya, Dilpreet Singh, Amit Page

и другие.

Journal of Macromolecular Science Part B, Год журнала: 2024, Номер unknown, С. 1 - 22

Опубликована: Дек. 30, 2024

This review focuses on how chitosan-based polymeric hydrogels improve cancer research, highlighting their physical properties and effects the tumor microenvironment (TME). Chitosan, a polymer that is both biocompatible biodegradable, becoming more popular because of its pH-responsive, mucoadhesive enzyme-sensitive characteristics, which enable controlled drug release better targeting TME. We believe this thoroughly covers various synthesis, modification crosslinking techniques used to develop these hydrogels, emphasizing role in enhancing targeting, addressing hypoxia improving retention. Important factors description involve incorporation chitosan into 3D models, delivery systems they contribute customizing treatments with biomimetic scaffolds. The manuscript highlights micromolecular physics influences structure ability deliver drugs effectively enhance treatment outcomes. Furthermore, compilation showcases flexibility containing different types chemotherapy biologics for range through examining case studies preclinical research. In end, clinical translational possibilities are analyzed, issues like scalability, extended safety, regulatory obstacles. conclusion stresses importance research future.

Язык: Английский

Nanoarchitectonics of biohybrid polymer nanocomposite of carboxylated chitosan-phthalate/SnO 2 nanoparticles for dye wastewater treatment: characterisation, isotherm, kinetic, and adsorption optimisation DOI
Ahmed Saud Abdulhameed,

Rima Heider Al Omari,

Samaa Abdullah

и другие.

International Journal of Environmental & Analytical Chemistry, Год журнала: 2024, Номер unknown, С. 1 - 22

Опубликована: Ноя. 20, 2024

Herein, a biohybrid polymer nanocomposite of carboxylated chitosan-phthalate/SnO2 nanoparticles (CTS-PHA/SnO2) was developed for dye wastewater treatment i.e. removal basic red 2 (BR2) dye. A study conducted using response surface methodology (RSM) to analyse the impact three factors on adsorption BR2 These were CTS-PHA/SnO2 dosage (0.02–0.08 g), pH (4–10), and time (10–30 min). The exhibited BET area 9.08 m2/g. total pore volume also determined be 0.0240 cm3/g, mean diameter measured 10.61 nm. mostly displays polycrystalline properties, as shown by its average crystallite size 19.85 kinetics isotherms indicate that Freundlich pseudo-first-order kinetic models accurately describe CTS-PHA/SnO2. findings BBD model suggest most effective conditions achieving high elimination rate (97.28%) 9.5, dose 0.052 g, contact 30 minutes. maximum absorption capacity towards computed 465.3 mg/g at temperature 25°C. proposed mechanism onto involves electrostatic interaction, π-π, hydrogen bonding, n-π stacking interaction. this material shows promise highly bioadsorbent treatment.

Язык: Английский

Процитировано

0

Advanced Relationships Between Structure and Properties of Chitosan-Based Polymeric Hydrogels in Oncology and Their Impact on the Tumor Microenvironment DOI
Sankha Bhattacharya, Dilpreet Singh, Amit Page

и другие.

Journal of Macromolecular Science Part B, Год журнала: 2024, Номер unknown, С. 1 - 22

Опубликована: Дек. 30, 2024

This review focuses on how chitosan-based polymeric hydrogels improve cancer research, highlighting their physical properties and effects the tumor microenvironment (TME). Chitosan, a polymer that is both biocompatible biodegradable, becoming more popular because of its pH-responsive, mucoadhesive enzyme-sensitive characteristics, which enable controlled drug release better targeting TME. We believe this thoroughly covers various synthesis, modification crosslinking techniques used to develop these hydrogels, emphasizing role in enhancing targeting, addressing hypoxia improving retention. Important factors description involve incorporation chitosan into 3D models, delivery systems they contribute customizing treatments with biomimetic scaffolds. The manuscript highlights micromolecular physics influences structure ability deliver drugs effectively enhance treatment outcomes. Furthermore, compilation showcases flexibility containing different types chemotherapy biologics for range through examining case studies preclinical research. In end, clinical translational possibilities are analyzed, issues like scalability, extended safety, regulatory obstacles. conclusion stresses importance research future.

Язык: Английский

Процитировано

0