ACS Sensors,
Год журнала:
2022,
Номер
7(10), С. 3014 - 3022
Опубликована: Окт. 19, 2022
Real-time
intraocular
pressure
(IOP)
monitoring
plays
a
crucial
role
in
glaucoma
diagnosis
and
treatment.
The
wireless
smart
contact
lens
based
on
flexible
inductor-capacitor-resistor
(LCR)
sensor
is
chip-free
battery-free,
demonstrating
excellent
application
potential
for
physiological
signal
monitoring.
To
promote
the
use
of
LCR
lenses
clinical
IOP
monitoring,
reliable,
comfortable
materials
should
be
used
sensitivity
needs
to
realized.
Here,
we
propose
method
producing
hydrogel-based
that
uses
conformal
stacking
technique,
solving
problems
swelling
hydrogel
spherical
integration
pyramid-microstructured
dielectric
elastomer.
vitro
porcine
eye
successfully
monitored
owing
high
capacitive
substrate.
In
addition,
glasses-integrated
impedance-matching
tunable
reader
remote
measurement
realized
by
enhancing
amplitude
increasing
reading
distance,
improving
portability
equipment.
With
above
improved
designs,
system
has
shows
substantial
promise
next-generation
daily
ocular
health
management.
Chemical Reviews,
Год журнала:
2022,
Номер
122(11), С. 10319 - 10392
Опубликована: Апрель 12, 2022
The
evolutionary
success
in
information
technology
has
been
sustained
by
the
rapid
growth
of
sensor
technology.
Recently,
advances
have
promoted
ambitious
requirement
to
build
intelligent
systems
that
can
be
controlled
external
stimuli
along
with
independent
operation,
adaptivity,
and
low
energy
expenditure.
Among
various
sensing
techniques,
field-effect
transistors
(FETs)
channels
made
two-dimensional
(2D)
materials
attract
increasing
attention
for
advantages
such
as
label-free
detection,
fast
response,
easy
capability
integration.
With
atomic
thickness,
2D
restrict
carrier
flow
within
material
surface
expose
it
directly
environment,
leading
efficient
signal
acquisition
conversion.
This
review
summarizes
latest
2D-materials-based
FET
(2D
FET)
sensors
a
comprehensive
manner
contains
material,
operating
principles,
fabrication
technologies,
proof-of-concept
applications,
prototypes.
First,
brief
description
background
fundamentals
is
provided.
subsequent
contents
summarize
physical,
chemical,
biological
their
applications.
Then,
we
highlight
challenges
commercialization
discuss
corresponding
solution
techniques.
following
section
presents
systematic
survey
recent
progress
developing
commercial
Lastly,
long-standing
efforts
prospective
future
development
FET-based
toward
commercialization.
A
closed-loop
system
that
can
mini-invasively
track
blood
glucose
and
intelligently
treat
diabetes
is
in
great
demand
for
modern
medicine,
yet
it
remains
challenging
to
realize.
Microneedles
technologies
have
recently
emerged
as
powerful
tools
transdermal
applications
with
inherent
painlessness
biosafety.
In
this
work,
the
first
time
authors'
knowledge,
a
fully
integrated
wearable
(IWCS)
based
on
mini-invasive
microneedle
platform
developed
situ
diabetic
sensing
treatment.
The
IWCS
consists
of
three
connected
modules:
1)
mesoporous
microneedle-reverse
iontophoretic
sensor;
2)
flexible
printed
circuit
board
control;
3)
microneedle-iontophoretic
insulin
delivery
component.
As
key
component,
microneedles
enable
painless
penetration
stratum
corneum,
implementing
subcutaneous
substance
exchange.
coupling
iontophoresis
significantly
enhances
extraction
enables
electrical
control.
This
demonstrated
accurately
monitor
fluctuations,
responsively
deliver
regulate
hyperglycemia
rat
model.
design
endows
highly
promising
improve
therapies
patients.
Chemical Reviews,
Год журнала:
2024,
Номер
124(2), С. 455 - 553
Опубликована: Янв. 4, 2024
In
the
era
of
Internet-of-things,
many
things
can
stay
connected;
however,
biological
systems,
including
those
necessary
for
human
health,
remain
unable
to
connected
global
Internet
due
lack
soft
conformal
biosensors.
The
fundamental
challenge
lies
in
fact
that
electronics
and
biology
are
distinct
incompatible,
as
they
based
on
different
materials
via
functioning
principles.
particular,
body
is
curvilinear,
yet
typically
rigid
planar.
Recent
advances
design
have
generated
tremendous
opportunities
wearable
bioelectronics,
which
may
bridge
gap,
enabling
ultimate
dream
healthcare
anyone,
anytime,
anywhere.
We
begin
with
a
review
historical
development
healthcare,
indicating
significant
trend
healthcare.
This
followed
by
focal
point
discussion
about
new
design,
particularly
low-dimensional
nanomaterials.
summarize
material
types
their
attributes
designing
bioelectronic
sensors;
we
also
cover
synthesis
fabrication
methods,
top-down,
bottom-up,
combined
approaches.
Next,
discuss
energy
challenges
progress
made
date.
addition
front-end
devices,
describe
back-end
machine
learning
algorithms,
artificial
intelligence,
telecommunication,
software.
Afterward,
integration
systems
been
applied
various
testbeds
real-world
settings,
laboratories
preclinical
clinical
environments.
Finally,
narrate
remaining
conjunction
our
perspectives.
Chemical Reviews,
Год журнала:
2023,
Номер
124(2), С. 318 - 419
Опубликована: Дек. 6, 2023
Flexible
electronics
have
recently
gained
considerable
attention
due
to
their
potential
provide
new
and
innovative
solutions
a
wide
range
of
challenges
in
various
electronic
fields.
These
require
specific
material
properties
performance
because
they
need
be
integrated
into
variety
surfaces
or
folded
rolled
for
newly
formatted
electronics.
Two-dimensional
(2D)
materials
emerged
as
promising
candidates
flexible
unique
mechanical,
electrical,
optical
properties,
well
compatibility
with
other
materials,
enabling
the
creation
devices.
This
article
provides
comprehensive
review
progress
made
developing
devices
using
2D
materials.
In
addition,
it
highlights
key
aspects
scalable
production,
device
fabrication
processes
applications,
along
important
examples
demonstrations
that
achieved
breakthroughs
wearable
applications.
Finally,
we
discuss
opportunities,
current
challenges,
solutions,
future
investigative
directions
about
this
field.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Май 17, 2022
Engineering
wearable
devices
that
can
wirelessly
track
intraocular
pressure
and
offer
feedback-medicine
administrations
are
highly
desirable
for
glaucoma
treatments,
yet
remain
challenging
due
to
issues
of
limited
sizes,
wireless
operations,
cross-coupling.
Here,
we
present
an
integrated
theranostic
contact
lens
in
situ
electrical
sensing
on-demand
anti-glaucoma
drug
delivery.
The
utilizes
a
compact
structural
design,
which
enables
high-degreed
integration
frequency
separation
on
the
curved
surface
lens.
modulus
could
ultra-sensitively
detect
fluctuations,
unique
cantilever
configuration
design
capacitive
circuit.
delivery
employs
efficient
power
transfer
circuit,
trigger
into
aqueous
chamber
via
iontophoresis.
minimally
invasive,
smart,
features
endow
as
promising
system
treatments.
Advanced Functional Materials,
Год журнала:
2022,
Номер
32(41)
Опубликована: Авг. 3, 2022
With
the
development
of
Internet
Things,
there
is
an
increasing
need
for
clean
energy
and
large‐scale
sensory
systems.
Triboelectric/piezoelectric
nanogenerators
(TENGs/PENGs),
have
attracted
considerable
attention
as
a
new
type
power
generation
terminal,
which
can
harvest
surrounding
convert
it
into
electrical
energy.
To
improve
output
performance
(NGs)
diversify
related
applications,
2D
materials
with
high
carrier
mobility
excellent
piezoelectric
properties
be
directly
used
or
integrated
different
types
self‐powered
sensors.
In
this
review,
authors
first
introduce
optoelectronic
materials,
followed
by
triboelectric
series
in
TENGs.
The
categories
sensors
based
on
are
then
summarized
according
to
their
structures
compositions.
We
also
discuss
detail
recent
applications
from
five
aspects.
Finally,
challenges
outlooks
research
field
featured.
Given
continuous
they
considered
significant
potential
biomedicine,
environmental
detection,
human
motion
monitoring,
harvesting,
smart
wearable
devices.
Advanced Materials,
Год журнала:
2022,
Номер
34(24)
Опубликована: Фев. 7, 2022
Abstract
The
eye
is
one
of
the
most
complex
organs
in
human
body,
containing
rich
and
critical
physiological
information
(e.g.,
intraocular
pressure,
corneal
temperature,
pH)
as
well
a
library
metabolite
biomarkers
glucose,
proteins,
specific
ions).
Smart
contact
lenses
(SCLs)
can
serve
wearable
intelligent
ocular
prosthetic
device
capable
noninvasive
continuous
monitoring
various
essential
physical/biochemical
parameters
drug
loading/delivery
for
treatment
diseases.
Advances
SCL
technologies
growing
public
interest
personalized
health
are
accelerating
research
more
than
ever
before.
Here,
current
status
potential
development
through
comprehensive
review
from
fabrication
to
applications
commercialization
discussed.
First,
material,
fabrication,
platform
designs
SCLs
diagnostic
therapeutic
Then,
latest
advances
clinical
translation
reviewed.
Later,
established
techniques
power
transfer
wireless
data
transmission
applied
devices
summarized.
An
outlook,
future
opportunities,
challenges
developing
next‐generation
also
provided.
With
rise
development,
this
new
paradigm
devices.
Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Сен. 20, 2022
Abstract
Continuous
monitoring
of
intraocular
pressure,
particularly
during
sleep,
remains
a
grand
challenge
in
glaucoma
care.
Here
we
introduce
class
smart
soft
contact
lenses,
enabling
the
continuous
24-hour
even
sleep.
Uniquely,
lenses
are
built
upon
various
commercial
brands
without
altering
their
intrinsic
properties
such
as
lens
power,
biocompatibility,
softness,
transparency,
wettability,
oxygen
transmissibility,
and
overnight
wearability.
We
show
that
can
seamlessly
fit
across
different
corneal
curvatures
thicknesses
human
eyes
therefore
accurately
measure
absolute
pressure
under
ambulatory
conditions.
perform
comprehensive
set
vivo
evaluations
rabbit,
dog,
from
normal
to
hypertension
confirm
superior
measurement
accuracy,
within-subject
repeatability,
user
comfort
beyond
current
wearable
ocular
tonometers.
envision
will
be
effective
