Mechanical Metamaterials for Bioengineering: In Vitro, Wearable, and Implantable Applications

Advanced Engineering Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Mechanical metamaterials represent a promising class of materials characterized by unconventional mechanical properties derived from their engineered architectures. In the realm bioengineering, these offer unique opportunities for applications spanning in vitro models, wearable devices, and implantable biomedical technologies. This review discusses recent advancements bioengineering contexts. metamaterials, tailored to mimic specific biological tissues, enhance fidelity relevance models disease modeling therapy testing. Integration into devices enables creation comfortable adaptive interfaces with human body. Utilization promotes tissue regeneration, supports biomechanical functions, minimizes host immune responses. Key design strategies material selection criteria critical optimizing performance biocompatibility are elucidated. Representative case studies demonstrating benchtop phantoms scaffolds (in platforms); footwear, architectured fabrics, epidermal sensors (wearables); cardiovascular, gastrointestinal, orthopedic multifunctional patches highlighted. Finally, challenges future directions field discussed, emphasizing potential transform research enabling novel functionalities improving outcomes across diverse use cases.

Язык: Английский

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Enhanced Bioactivity and Mechanical Strength of Strontium-Doped Calcium Silicate Bioceramic Prepared Through Sol–Gel Combustion Synthesis

Silicon, Год журнала: 2025, Номер unknown

Опубликована: Март 8, 2025

Язык: Английский

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Covalently Grafted Biomimetic Matrix Reconstructs the Regenerative Microenvironment of the Porous Gradient Polycaprolactone Scaffold to Accelerate Bone Remodeling

Small, Год журнала: 2023, Номер 19(19)

Опубликована: Фев. 11, 2023

Abstract Integrating a biomimetic extracellular matrix to improve the microenvironment of 3D printing scaffolds is an emerging strategy for bone substitute design. Here, “soft–hard” implant (BM‐g‐DPCL) consisting bioactive chemically integrated on polydopamine (PDA)‐coated porous gradient scaffold by polyphenol groups constructed. The PDA‐coated “hard” promoted Ca 2+ chelation and mineral deposition; “soft” beneficial migration, proliferation, osteogenic differentiation stem cells in vitro, accelerated endogenous cell recruitment, initiated rapid angiogenesis vivo. results rabbit cranial defect model (Φ = 10 mm) confirmed that BM‐g‐DPCL integration between tissue induced deposition matrix. Proteomics cytokine adhesion, biomineralization, vascularization, formation are major factors accelerate healing. This highly bonded soft–hard components guided construction regenerative scaffold.

Язык: Английский

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Polysaccharide-based antibacterial nanocomposite hydrogels with Janus structure for treatment of infected extraction socket

Science China Materials, Год журнала: 2024, Номер 67(8), С. 2550 - 2557

Опубликована: Апрель 1, 2024

Язык: Английский

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Polyvinyl alcohol/collagen composite scaffold reinforced with biodegradable polyesters/gelatin nanofibers for adipose tissue engineering

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 263, С. 130237 - 130237

Опубликована: Фев. 17, 2024

Язык: Английский

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