Covalent Organic Frameworks: Recent Progress in Biomedical Applications

ACS Nano, Год журнала: 2023, Номер 17(3), С. 1879 - 1905

Опубликована: Янв. 30, 2023

Covalent organic frameworks (COFs) are a type of crystalline porous material with specific features and interesting structures, including porosity, large surface area, biocompatibility. These enable COFs to be considered as excellent candidates for applications in various fields. Recently, have been widely demonstrated promising materials biomedical because their physicochemical properties ultrathin structures. In this review, we cover the recent progress COF photodynamic therapy, gene delivery, photothermal drug bioimaging, biosensing, combined therapies. Moreover, critical challenges further perspectives regards future biology-facing also discussed.

Язык: Английский

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Progress in Gelatin as Biomaterial for Tissue Engineering

Pharmaceutics, Год журнала: 2022, Номер 14(6), С. 1177 - 1177

Опубликована: Май 31, 2022

Tissue engineering has become a medical alternative in this society with an ever-increasing lifespan. Advances the areas of technology and biomaterials have facilitated use engineered constructs for issues. This review discusses on-going concerns latest developments widely employed biomaterial field tissue engineering: gelatin. Emerging techniques including 3D bioprinting gelatin functionalization demonstrated better mimicking native by reinforcing gelatin-based systems, among others. breakthrough facilitates, on one hand, manufacturing process when it comes to practicality cost-effectiveness, which plays key role transition towards clinical application. On other can be concluded that could considered as promising future trends, focus might detection diagnosis diseases rather than treatment.

Язык: Английский

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Beyond Ti-based MXenes: A review of emerging non-Ti based metal-MXene structure, properties, and applications

Materials Today, Год журнала: 2023, Номер 63, С. 313 - 338

Опубликована: Фев. 18, 2023

Язык: Английский

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Chitosan-based nanostructured biomaterials: Synthesis, properties, and biomedical applications

Advanced Industrial and Engineering Polymer Research, Год журнала: 2023, Номер 7(1), С. 79 - 99

Опубликована: Июль 19, 2023

Chitosan is obtained from chitin, which abundantly found in crustaceans and through various methods. The demineralization, deproteinization, discoloration, deacetylation of chitin produce chitosan consisting D-glucosamine N-acetyl units that are linked β-(1,4)-glycosidic linkages. has gained significant attention the biomedical field due to its unique properties such as abundance, renewability, non-toxic nature, antimicrobial activity, biodegradability, polyfunctionality. One key why it been heavily utilized field. To provide a comprehensive overview chitosan, this review discusses extraction based on source It also delves into chemical modifications nanocomposite development using natural synthetic materials. emphasizes multitude make an excellent choice for wide range applications. mechanisms antibacterial activity factors affecting activity. Additionally, highlights hemocompatibility, antioxidant anti-inflammation, other contribute suitability different applications, including wound dressing materials, drug delivery carriers, biosensing diagnostic devices, bone substitutes, bioimaging. While discussing some limitations concludes with future perspective developing multifunctional chitosan-based nanomaterials could potentially move laboratory clinical trials treating diseases.

Язык: Английский

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Recent trends in MXene-based material for biomedical applications

Environmental Research, Год журнала: 2023, Номер 222, С. 115337 - 115337

Опубликована: Янв. 20, 2023

Язык: Английский

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Porous organic polymers with defined morphologies: Synthesis, assembly, and emerging applications

Progress in Polymer Science, Год журнала: 2023, Номер 142, С. 101691 - 101691

Опубликована: Май 6, 2023

Язык: Английский

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Extracellular vesicles as bioactive nanotherapeutics: An emerging paradigm for regenerative medicine

Theranostics, Год журнала: 2022, Номер 12(11), С. 4879 - 4903

Опубликована: Янв. 1, 2022

In recent decades, extracellular vesicles (EVs), as bioactive cell-secreted nanoparticles which are involved in various physiological and pathological processes including cell proliferation, immune regulation, angiogenesis tissue repair, have emerged one of the most attractive nanotherapeutics for regenerative medicine. Herein we provide a systematic review latest progress EVs applications. Firstly, will briefly introduce biogenesis, function isolation technology EVs. Then, underlying therapeutic mechanisms native unmodified engineering strategies modified entities be discussed. Subsequently, main focus placed on repair regeneration applications organs brain, heart, bone cartilage, liver kidney, well skin. More importantly, current clinical trials medicine also highlighted. Finally, future challenges insightful perspectives currently developed EV-based biomedicine short, opened new horizons biologists, chemists, nanoscientists, pharmacists, clinicians, making possible powerful tools therapies

Язык: Английский

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Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications

Bioactive Materials, Год журнала: 2024, Номер 35, С. 181 - 207

Опубликована: Фев. 2, 2024

Peptide molecules have design flexibility, self-assembly ability, high biocompatibility, good biodegradability, and easy functionalization, which promote their applications as versatile biomaterials for tissue engineering biomedicine. In addition, the functionalization of self-assembled peptide nanomaterials with other additive components enhances stimuli-responsive functions, promoting function-specific that induced by both internal external stimulations. this review, we demonstrate recent advance in molecular design, self-assembly, functional tailoring, biomedical peptide-based nanomaterials. The strategies on synthesis single, dual, multiple various dimensions are analyzed, regulation active such metal/metal oxide, DNA/RNA, polysaccharides, photosensitizers, 2D materials, others discussed. designed temperature-, pH-, ion-, light-, enzyme-, ROS-responsive abilities drug delivery, bioimaging, cancer therapy, gene antibacterial, well wound healing dressing presented This comprehensive review provides detailed methodologies advanced techniques from biology, materials science, nanotechnology, will guide inspire level peptides specific functions applications.

Язык: Английский

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CHARMM-GUI Membrane Builder: Past, Current, and Future Developments and Applications

Journal of Chemical Theory and Computation, Год журнала: 2023, Номер 19(8), С. 2161 - 2185

Опубликована: Апрель 4, 2023

Molecular dynamics simulations of membranes and membrane proteins serve as computational microscopes, revealing coordinated events at the interface. As G protein-coupled receptors, ion channels, transporters, membrane-bound enzymes are important drug targets, understanding their binding action mechanisms in a realistic becomes critical. Advances materials science physical chemistry further demand an atomistic lipid domains interactions between membranes. Despite wide range simulation studies, generating complex assembly remains challenging. Here, we review capability CHARMM-GUI

Язык: Английский

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Carbon nanomaterials-based electrochemical aptasensor for point-of-care diagnostics of cancer biomarkers

Materials Today Chemistry, Год журнала: 2023, Номер 30, С. 101499 - 101499

Опубликована: Апрель 18, 2023

Язык: Английский

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