Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
The
enzyme-linked
immunosorbent
assay
(ELISA)
stands
as
one
of
the
most
frequently
employed
rapid
detection
techniques
for
both
chemical
and
biological
contaminants.
Horseradish
peroxidase
(HRP)
hydrogen
peroxide
(H2O2),
serving
signal
generators,
play
indispensable
roles
throughout
entire
ELISA
process.
However,
HRP
H2O2
exhibit
high
sensitivity
to
elevated
temperatures,
hindering
broader
utilization
transportation
ELISA.
Hereby,
being
inspired
by
cascade
catalysis
glucose
oxidase
(GOx)
well
advantageous
properties
metal–organic
frameworks
(MOFs),
we
developed
a
catalysis-based
competitive
fluorescent
(CCF-ELISA)
mycotoxin
in
maize
using
zearalenone
(ZEN)
model.
results
revealed
remarkable
protective
effects
MOFs
on
enzymatic
activities.
Based
upon
characteristics,
built
CCF-ELISA
enabled
ZEN
with
half-maximal
inhibitory
concentration
0.54
ng/mL
allowed
range
from
0.19
1.51
ng/mL.
When
applied
naturally
contaminated
samples,
outcomes
obtained
showed
level
comparability
high-performance
liquid
chromatography–tandem
mass
spectrometry,
demonstrating
promising
potential
food
security.
RSC Advances,
Год журнала:
2024,
Номер
14(41), С. 30201 - 30229
Опубликована: Янв. 1, 2024
Recently,
metal-organic
frameworks
(MOFs)
have
attracted
much
attention
as
versatile
materials
for
drug
delivery
and
personalized
medicine.
MOFs
are
porous
structures
made
up
of
metal
ions
coupled
with
organic
ligands.
This
review
highlights
the
synthesis
techniques
used
to
design
specific
features
such
surface
area
pore
size,
encapsulation
within
not
only
improves
their
stability
solubility
but
also
allows
controlled
release
kinetics,
which
therapeutic
efficacy
minimizes
adverse
effects.
Furthermore,
it
discusses
challenges
potential
advantages
MOF-based
delivery,
MOF
stability,
biocompatibility,
scale-up
production.
With
further
advancements
in
synthesis,
functionalization
techniques,
understanding
interactions
using
biological
systems,
can
significant
promise
expanding
medicine
improving
patient
outcomes.
eScience,
Год журнала:
2024,
Номер
4(3), С. 100231 - 100231
Опубликована: Янв. 21, 2024
Stimuli-responsive
coordination
polymers
(CPs)
are
among
one
of
the
most
prolific
research
areas
in
developing
next-generation
functional
materials.
Their
capability
being
accurately
excited
by
particular
external
changes
with
pre-determined
and
observable/characterizable
behaviours
correspond,
so
called
"stimuli"
"responsive".
Abundant
types
CP
compounds,
especially
metal-organic
frameworks
(MOFs),
rocketing
interest
owing
to
their
compositional
diversity,
structural
tunability,
essence
highly
engineerable
functionality.
This
present
review
is
aimed
sketch
several
common
stimulation
corresponding
responses
for
CPs,
accompanied
broad
logic
mechanisms
underneath.
And
further
from
aspect
material
revolution,
some
representative
progresses
together
latest
advances
CP-based
materials
various
fields
covered
attempt
display
a
broader
picture
towards
possible
prospects
this
topic.
National Science Review,
Год журнала:
2024,
Номер
11(8)
Опубликована: Июнь 26, 2024
ABSTRACT
Periodontitis
involves
hyperactivated
stromal
cells
that
recruit
immune
cells,
exacerbating
inflammation.
This
study
presents
an
ATP-responsive
metal–organic
framework
(Mg/Zn-MOF)
designed
for
periodontitis
treatment,
utilizing
ion
interference
to
modulate
responses
and
prevent
tissue
destruction.
Addressing
the
challenges
of
synergistic
effects
targeted
delivery
faced
by
traditional
immunomodulatory
nanomaterials,
Mg/Zn-MOF
system
is
activated
extracellular
ATP—a
pivotal
molecule
in
pathology—ensuring
release.
Magnesium
zinc
ions
released
from
synergistically
inhibit
membrane
pore
formation
attenuating
Gasdermin
D
(GSDMD)
expression
activation.
action
curtails
pyroptosis,
lactate
dehydrogenase
IL-1β
release,
thwarting
onset
inflammatory
cascades.
Mechanistically,
intervenes
both
NLRP3/Caspase-1/GSDMD
Caspase-11/GSDMD
pathways
mitigate
pyroptosis.
In
vivo
assessments
confirm
its
effectiveness
diminishing
cell
infiltration
preserving
collagen
integrity,
thereby
safeguarding
against
periodontal
damage
bone
loss.
investigation
highlights
promise
ion-interference
strategies
immunotherapy,
representing
a
significant
stride
developing
therapeutic
approaches.
