Nanoodor Particles Deliver Drugs to Central Nervous System via Olfactory Pathway
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
Central
nervous
system
(CNS)
disorders
confront
significant
challenges
in
drug
delivery
due
to
the
blood-brain
barrier
(BBB).
Inspired
by
rapid
and
precise
binding
of
odor
molecules
olfactory
receptors
(ORs),
this
research
uses
thiolated
HPMA
construct
nanoparticles
(nanoodors)
capable
delivering
drugs
CNS
via
olfacto-cerebral
pathway
overcome
obstruction.
The
nanoodor
core
is
used
encapsulate
agomelatine
(AGO),
a
CNS-targeting
antidepressant,
encapsulation
efficiency
exceeded
80%.
A
series
thiol-presenting
nanoscale
structures
with
different
surface
densities
thiol
groups
are
constructed,
effectiveness
positively
correlated
density
on
their
surface.
Notably,
nanoodors
enable
brain-targeted
delivery,
outperforming
commercially
available
oral
formulations
terms
accumulation
brain
antidepressant
effects.
study
transport
action
mechanisms
revealed
that
after
ORs,
rapidly
delivered
pathway.
Nanoodors,
first
design
deliver
mimicking
natural
smells
for
treatment
disorders,
expected
achieve
clinical
transformation,
benefiting
human
health.
Язык: Английский
Nanoparticle Strategies for Treating CNS Disorders: A Comprehensive Review of Drug Delivery and Theranostic Applications
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13302 - 13302
Опубликована: Дек. 11, 2024
This
review
aims
to
address
the
significant
challenges
of
treating
central
nervous
system
(CNS)
disorders
such
as
neurodegenerative
diseases,
strokes,
spinal
cord
injuries,
and
brain
tumors.
These
are
difficult
manage
due
complexity
disease
mechanisms
protective
blood–brain
barrier
(BBB),
which
restricts
drug
delivery.
Recent
advancements
in
nanoparticle
(NP)
technologies
offer
promising
solutions,
with
potential
applications
delivery,
neuroprotection,
neuroregeneration.
By
examining
current
research,
we
explore
how
NPs
can
cross
BBB,
deliver
medications
directly
targeted
CNS
regions,
enhance
both
diagnostics
treatment.
Key
NP
strategies,
passive
targeting,
receptor-mediated
transport,
stimuli-responsive
systems,
demonstrate
encouraging
results.
Studies
show
that
may
improve
minimize
side
effects,
increase
therapeutic
effectiveness
models
Alzheimer’s,
Parkinson’s,
stroke,
glioblastoma.
thus
represent
a
approach
for
disorder
management,
combining
delivery
diagnostic
capabilities
enable
more
precise
effective
treatments
could
significantly
benefit
patient
outcomes.
Язык: Английский
Editorial: Micro/nano devices and technologies for neural science and medical applications
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 6, 2025
application
in
brain-computer
interfaces
(Wang
et
al.,
2024).
Han
al.
designed
and
fabricated
an
implantable
microelectrode
array
specifically
for
electrophysiological
signal
detection
analysis
within
the
striatal
region
of
basal
ganglia
epileptic
rats.
The
data
from
striatum
during
episodes
epilepsy
provides
valuable
insights
into
dynamic
processes
governing
neural
activity
both
initial
onset
phases
as
well
latent
periods
associated
with
temporal
lobe
epilepsy.
This
understanding
contributes
to
unraveling
mechanisms
involved
while
promoting
advancements
related
therapeutic
approaches
this
condition.
Pain
is
emotional
unpleasant
sensory
experience
that
can
lead
significant
physiological
psychological
effects
across
various
aspects
life
work.
Recent
nanotechnology
have
paved
way
innovative
pain
relief
strategies
utilizing
diverse
nanomaterials
targeted
surface
modifications
(Shi
2023).
Zhu
summarized
status
research
global
trends
relation
management.
Neuromodulation
represents
another
approach
alleviating
by
modulating
abnormal
nerve
through
light,
sound,
or
electrical
stimulation.
Nanomaterials
such
carbon
nanotubes,
graphene,
piezoelectric
ceramics,
magnetic
metals
garnered
extensive
interest
use
wearable
devices
neuromodulation.
In
conclusion,
emerging
novel
drugs
technologies
present
a
wide
options
effective
biomarkers
holds
importance
disease
diagnosis
treatment
science
(Sun
2022).
Biosensors
are
specialized
sensors
capable
detecting
broad
spectrum
biological
chemical
substances.
integration
field
biosensors
has
enhanced
their
sensitivity
along
other
critical
properties,
leading
development
biosensing
solutions.
Focusing
on
E2
specifically,
Wang
reviewed
applications
new
functional
discussing
whether
modified
bioreceptors
energy
exchange
enable
these
enhance
sensing
performance
improved
conversion
rates,
amplification
capabilities,
biocompatibility.
Nanoenzymes
represent
class
exhibiting
enzyme-like
attracted
considerable
attention
biomedical
recent
years.
Compared
traditional
enzymes,
nanoenzymes
demonstrate
superior
stability
alongside
greater
heat
resistance
broader
pH
adaptability
ranges;
characteristics
underscore
substantial
potential
(Christodoulou,
Chen
classified
metal-organic
framework
(MOF)-based
nanozymes,
analyzed
stroke
highlighted
challenges
developing
efficient
antioxidant
nanozyme
systems
treatment.
Micro-nano
technology
currently
at
forefront
technological
advancement,
significantly
enhancing
regulation
capabilities.
We
leverage
micro-nano
develop
equipment
tailored
specific
needs.
To
address
demand
deep
brain
regulation,
it
essential
create
miniaturized,
high-throughput
braincomputer
response
point-of-care
testing
(POCT)
requirements,
we
must
focus
offer
rapid
times,
high
sensitivity,
user-friendly
operation.
Utilizing
allows
design
miniaturized
sensor
achieving
previously
unattainable
levels
detection.
For
instance,
nervous
system
transmits
information
two
fundamental
modes:
signals
cells
transmitters
(dual-mode).
dual-mode
mitigate
loss
single-mode
recording.
advancement
scientific
value
researching
diseases
advancing
our
science.We
believe
ongoing
innovation,
will
play
pivotal
role
driving
progress
neuroscience
clinical
medicine.
Язык: Английский
Gadolinium-Ceria Hybrid System Enables Synergistic Alleviation of Oxidative Stress and Metabolic Thrombo-Inflammation for Efficient Ischemic Stroke Treatment
Biomaterials,
Год журнала:
2025,
Номер
322, С. 123379 - 123379
Опубликована: Апрель 28, 2025
Язык: Английский
Synergistic Gold Nanorod‐based Chemo‐Photothermal Therapy: A Promising Nanoparticle Approach for Refractory Multidrug‐Resistant Cancer
ChemBioEng Reviews,
Год журнала:
2024,
Номер
11(4)
Опубликована: Июль 25, 2024
Abstract
Multidrug
resistance
(MDR)
remains
a
formidable
challenge
in
cancer
treatment,
necessitating
innovative
strategies
to
enhance
therapeutic
outcomes.
This
review
explores
the
potential
of
synergistic
gold
nanorod
(GNR)
therapy
(SGNRT)
utilizing
GNRs
as
multifunctional
platforms
for
co‐delivering
chemotherapy
and
thermal
therapies.
The
rational
design
SGNRT
systems
enables
targeted
payload
delivery,
circumvention
Adenosine
triphosphate
(ATP)‐binding
cassette
drug
efflux
transporters,
hyperthermia‐induced
chemo
sensitization.
In
vitro
studies
demonstrate
impact
overcoming
MDR,
emphasizing
its
enhanced
antitumor
efficacy.
However,
further
vivo
investigations
are
essential
assess
clinical
viability
this
nanoparticle
(NP)‐directed
approach
against
advanced
multidrug‐resistant
malignancies.
integration
holds
promise
advancing
precision
therapies
addressing
intricate
challenges
settings.
Язык: Английский
The Therapeutic Potential of Harpagophytum procumbens and Turnera subulata and Advances in Nutraceutical Delivery Systems in Neurodegenerative Diseases
Pharmaceuticals,
Год журнала:
2024,
Номер
17(5), С. 660 - 660
Опубликована: Май 20, 2024
This
review
article
covers
the
therapeutic
potential
of
plants
Harpagophytum
procumbens
and
Turnera
subulata
in
treatment
neurodegenerative
diseases.
Despite
recognition
their
beneficial
properties,
there
is
notable
shortage
specific
clinical
vitro
studies
on
these
species
regarding
Compounds
such
as
harpagosides
vite-xin-2-O-rhamnoside,
found
subulata,
respectively,
well
other
antioxidants
anti-inflammatory
agents,
are
associated
with
mechanisms
action
that
involve
reducing
oxidative
stress
modulating
inflammatory
response,
indicating
pathologies.
Additionally,
use
nutraceuticals
derived
from
medicinal
has
emerged
a
promising
approach,
offering
natural
alternatives.
However,
pressing
need
for
focusing
pharmacokinetics,
safety,
pharmacological
interactions
extracts
diseases
emphasized.
also
evaluated
advances
nutraceutical
delivery
systems,
highlighting
technological
innovations
can
optimize
precise
compounds
to
patients.
Such
findings
highlight
gaps
study
and,
at
same
time,
opening
new
perspectives
diseases,
providing
expectations
innovative
solutions
this
critical
domain
medicine.
Язык: Английский
Functional Roles of Long Non-coding RNAs on Stem Cell-related Pathways in Glioblastoma
Arya Moftakhar,
Seyed Esmaeil Khoshnam,
Maryam Farzaneh
и другие.
Current Signal Transduction Therapy,
Год журнала:
2024,
Номер
19(3)
Опубликована: Июль 4, 2024
:
Long
non-coding
RNAs
(lncRNAs),
characterized
by
their
length
exceeding
200
nucleotides
and
lack
of
protein-coding
capacity,
are
intricately
associated
with
a
wide
array
cellular
processes,
encompassing
cell
invasion,
differentiation,
proliferation,
migration,
apoptosis,
regeneration.
Perturbations
in
lncRNA
expression
have
been
observed
numerous
diseases
emerged
as
pivotal
players
the
pathogenesis
diverse
tumor
types.
Glioblastoma,
highly
malignant
primary
central
nervous
system
(CNS),
remains
formidable
challenge
even
advent
novel
therapeutic
interventions,
glioblastomas
invariably
exhibit
therapy
resistance
aggressive
behavior.
Glioblastomas
can
arise
from
progenitor
cells
or
neuroglial
stem
cells,
revealing
profound
heterogeneity,
notably
form
glioblastoma
(GSCs)
possessing
stem-like
properties.
comprise
neural
precursors
that
harbor
essential
characteristics
(NSCs).
Several
signaling
pathways
implicated
regulation
self-renewal
both
cancer
cells.
In
addition
to
involvement
survival
glioblastoma,
lncRNAs
modulation
GSC
behaviors
through
intricate
various
genes
proteins.
This
review
aims
comprehensively
discuss
interplay
between
lncRNAs,
pathways,
GSCs,
shedding
light
on
potential
implications
glioblastoma.
Язык: Английский
The therapeutic potential of immunomodulatory nucleic acid nanoparticles in the treatment of CNS infections
Nanomedicine,
Год журнала:
2024,
Номер
unknown, С. 1 - 4
Опубликована: Дек. 4, 2024
Язык: Английский
Progress in the treatment of Alzheimer's Disease based on nanosized Traditional Chinese Medicine
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 5, 2024
Traditional
Chinese
medicine
(TCM)
has
been
employed
for
centuries
in
treating
and
managing
Alzheimer's
disease
(AD).
However,
their
effective
delivery
to
target
sites
can
be
a
major
challenge.
This
is
due
poor
water
solubility,
low
bioavailability,
potential
toxicity.
Furthermore,
the
blood-brain
barrier
(BBB)
obstacle
TCM
delivery,
significantly
reducing
efficacy.
Advancements
nanotechnology
its
applications
(nano-TCM)
deliver
active
ingredients
or
components
of
across
BBB
targeted
brain
area.
review
summarizes
recent
advances
nanocarrier-based
systems
different
types
constituents
AD,
including
terpenoids,
polyphenols,
alkaloids,
flavonoids,
quinones.
Besides,
main
challenges
opportunities
future
development
these
advanced
nanocarriers
are
emphasized.
In
conclusion,
this
provides
valuable
insights
guidance
utilizing
shape
drug
delivery.
Язык: Английский