Accounts of Materials Research, Год журнала: 2024, Номер 5(11), С. 1440 - 1452

Опубликована: Окт. 23, 2024

ConspectusNatural or bioengineered living organisms (including mammalian cells, bacteria, microalgaes, yeast, viruses, plant and the multiple organism community) possess many intrinsic artificial superiorities than synthesized inert biomaterials for application in fields, especially biomedical applications. By leveraging inherent therapeutic competences (e.g., disease chemotaxis, drugs production, intelligent delivery, immune activation metabolic regulation), these have been developed as critical formulations applications to solve unmet medical needs. These are more intelligent, easily available, highly active, strongly curative conventional formulations, such inorganic nanocarriers, metal–organic chelating networks, polymeric nanovesicles biomembrane biohybrids, etc. Nevertheless, nonspecific vivo circulation, diseased microenvironment-triggered inactivation, uncontrolled proliferation colonization, unexpected side effects, unsatisfactory effect severely restricted their further research development clinical approval. Living biomaterials, fabricated by integrating tailored functional materials with natural chemical conjugation, physical assembly, biological engineering strategies well advanced construction techniques, rapidly preserve augment bioactivity properties of even control behaviors, decrease biotoxicity, impart them new biofunctionalities, like stress resistance, maintenance, safe trafficking, controllable evolved metabolism properties. acquired capacities beneficial improve potency compliance, significant restrictions, avoid biosafety questions, enhance performances, extend boundaries on science practical Additionally, introduction biocompatible instructive materials, synthetic polymers polypeptides, proteins enzymes, component can also promote interaction body provide feedback adapt biofunctions organisms.In this Account, we present a brief overview recent advances fabrication applications, embracing species communities. We introduce typical practicable methods techniques mainly including editing, engineering. On basis strategies, representative examples therapy tumors, disorders, metal poisoning, inflammatory bowel diseases (IBD), organ failure, etc.) summarized discussed. Finally, highlight main drawbacks, current challenges, potential solutions, future opportunities biomaterial

Язык: Английский