Acid-resistant chemotactic DNA micromotors for probiotic delivery in inflammatory bowel disease DOI Creative Commons

Zinan Zhao,

Xu Yao,

Yong Hu

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 22, 2025

Microcapsules composed of synthetic polymeric matrices have attracted considerable attention in delivering oral probiotics. However, existing microcapsules demonstrate inadequate acid resistance and adaptability, as well deficiency the inflamed colon-specificity uncontrolled release probiotics therein. Herein, a DNA microcapsule is prepared probiotic-transporting micromotor through photo-crosslinking hyaluronic methacrylate acrydite-modified A-/C-rich oligomers within microfludically generated droplets presence nitric oxide-cleavable crosslinker gas donor manganese carbonyl (MnCO). As traverse stomach, duodenum, ultimately colon, formation dissociation A-motif i-motif structures instigate reversible shrinking-swelling transition to preserve probiotic viability. Subsequently, exhibit chemotaxis towards colon site, driven by gas-generating reaction between MnCO elevated reactive oxygen species. Following disintegration microcapsules, triggered endogenous oxide, are released reshape dysbiosis intestinal microflora. This advanced delivery system offers significant promise for effective clinical management inflammatory bowel disease.

Язык: Английский

Acid-resistant chemotactic DNA micromotors for probiotic delivery in inflammatory bowel disease DOI Creative Commons

Zinan Zhao,

Xu Yao,

Yong Hu

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 22, 2025

Microcapsules composed of synthetic polymeric matrices have attracted considerable attention in delivering oral probiotics. However, existing microcapsules demonstrate inadequate acid resistance and adaptability, as well deficiency the inflamed colon-specificity uncontrolled release probiotics therein. Herein, a DNA microcapsule is prepared probiotic-transporting micromotor through photo-crosslinking hyaluronic methacrylate acrydite-modified A-/C-rich oligomers within microfludically generated droplets presence nitric oxide-cleavable crosslinker gas donor manganese carbonyl (MnCO). As traverse stomach, duodenum, ultimately colon, formation dissociation A-motif i-motif structures instigate reversible shrinking-swelling transition to preserve probiotic viability. Subsequently, exhibit chemotaxis towards colon site, driven by gas-generating reaction between MnCO elevated reactive oxygen species. Following disintegration microcapsules, triggered endogenous oxide, are released reshape dysbiosis intestinal microflora. This advanced delivery system offers significant promise for effective clinical management inflammatory bowel disease.

Язык: Английский

Процитировано

0