Organocatalytic Deoxygenative [3+2] Cycloaddition of N-Hydroxyamides with Alkynes to Access Isoxazoles DOI
Haixiang Wang, Yan Sun,

Wentong Liu

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Сен. 12, 2024

Although the transition-metal-catalyzed [3+2] cycloadditions to access isoxazoles have been described well, organocatalytic methods remain underdeveloped. Herein, we report use of an organophosphine catalyst for preparation a series with exceptional regioselectivity via cycloaddition

Язык: Английский

Skeletal Editing of Isatins for Heterocycle Molecular Diversity DOI
Tiantian Zhang, Huangdi Feng

The Chemical Record, Год журнала: 2024, Номер 24(6)

Опубликована: Июнь 1, 2024

Isatins have been widely used in the preparation of a variety heterocyclic compounds, where skeletal editing isatins has shown significant advantages for construction diverse heterocycles. This review highlights progress made last decade (2013-2023) isatin scaffold. A series ring expansion reactions quinoline skeleton, quinolone polycyclic quinazoline medium-sized as well opening generation 2-(azoly)aniline skeleton by cleavage C-C bond and C-N are highlighted. It is hoped that this will provide some understanding chemical transformations contribute to further realization its molecular diversity.

Язык: Английский

Процитировано

5
Sequence [2,3]‐Sigmatropic Rearrangement: One‐Pot Synthesis of Propargyl Allenylamines DOI
Huihui Feng,

Yujuan Xie,

Liliang Huang

и другие.

Chinese Journal of Chemistry, Год журнала: 2024, Номер 42(18), С. 2223 - 2227

Опубликована: Май 14, 2024

Comprehensive Summary Allenes, served as highly sought‐after building blocks, are an indispensable component of synthetic chemistry. Their utility in modulating the chemical, physical, and pharmaceutical properties organic compounds make allenes a desirable choice various applications. Here, we report facile method for atom‐economical synthesis propargyl allenylamines via underdeveloped [2,3]‐sigmatropic rearrangement. Our strategy employs easily accessible propargylamines starting materials, which first converted into ammonium salts, followed by base‐promoted This one‐pot, two‐step reaction proceeds absence transition metals, displays very broad scope, does not require introduction electron‐withdrawing group materials.

Язык: Английский

Процитировано

4
Synthesis of Tetrasubstituted Pyrroles via DBU-Mediated Cyclization of Unactivated Propargyl Tertiary Amines DOI
Pengyu Zhou, Tiantian Zhang, Q. Richard Lu

и другие.

The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Compared with the well-developed cyclization of functionalized propargylamines, use unactivated tertiary propargylamines to access pyrroles remains challenging. Herein, we report an efficient method for constructing tetrasubstituted via a DBU-mediated intramolecular cycloaddition N-alkyl propargylamines. This reaction employs dihydropyrrole intermediates, followed by oxidation produce in presence 2,3-dichloro-5,6-dicyano-p-benzoquinone. In addition, broad substrate scope, high atom economy, selectivity, and simple operation are also advantages this protocol.

Язык: Английский

Процитировано

0
Amine-catalyzed metal-free deamination of propargylamines with water toward chalcones DOI
Pengyu Zhou, Liliang Huang,

Yujuan Xie

и другие.

Molecular Catalysis, Год журнала: 2022, Номер 534, С. 112808 - 112808

Опубликована: Ноя. 18, 2022

Язык: Английский

Процитировано

9
Synthesis of oxazolines through a Pd-catalyzed alkyne-enabled C N activation of oxazolidines DOI

Ling Zhong,

Ruidan Shi,

Liliang Huang

и другие.

Tetrahedron Letters, Год журнала: 2023, Номер 134, С. 154882 - 154882

Опубликована: Дек. 9, 2023

Язык: Английский

Процитировано

5
Metal- and oxidant-free skeletal reorganizing of oxazolidines to access N-Vinylpyrroles DOI

Ruidan Shi,

Xianjun Xu,

Ling Zhong

и другие.

Sustainable Chemistry and Pharmacy, Год журнала: 2024, Номер 42, С. 101768 - 101768

Опубликована: Сен. 17, 2024

Язык: Английский

Процитировано

1
An asymmetric metal-templated route to amino acids with an isoquinolone core via a Rh(iii)-catalyzed coupling of aryl hydroxamates with chiral propargylglycine Ni(ii) complexes DOI
Mikhail A. Arsenov,

Nadezhda V. Stoletova,

Tat’yana F. Savel’yeva

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2022, Номер 20(47), С. 9385 - 9391

Опубликована: Янв. 1, 2022

The first asymmetric route to artificial amino acids with an isoquinolone skeleton was elaborated via a straightforward Rh( iii )-catalyzed C–H activation/annulation reaction.

Язык: Английский

Процитировано

4
Synthesis ofN-alkenylisoquinolinonesviapalladium-catalyzed cyclization/C4–O bond cleavage of oxazolidines DOI

Xianjun Xu,

Liliang Huang,

Eva Smits

и другие.

New Journal of Chemistry, Год журнала: 2022, Номер 46(44), С. 21176 - 21180

Опубликована: Янв. 1, 2022

A palladium-catalyzed cascade ring-opening reaction to synthesize N -alkenylisoquinolinones via cyclization and C–O bond cleavage is reported.

Язык: Английский

Процитировано

4
Organocatalytic Deoxygenative [3+2] Cycloaddition of N-Hydroxyamides with Alkynes to Access Isoxazoles DOI
Haixiang Wang, Yan Sun,

Wentong Liu

и другие.

Organic Letters, Год журнала: 2024, Номер unknown

Опубликована: Сен. 12, 2024

Although the transition-metal-catalyzed [3+2] cycloadditions to access isoxazoles have been described well, organocatalytic methods remain underdeveloped. Herein, we report use of an organophosphine catalyst for preparation a series with exceptional regioselectivity via cycloaddition

Язык: Английский

Процитировано

0