Synthesis of Nafimidone Derivatives by Visible-Light-Induced α-C—H Functionalization of Carbonyl
Chinese Journal of Organic Chemistry,
Год журнала:
2025,
Номер
45(2), С. 677 - 677
Опубликована: Янв. 1, 2025
Язык: Английский
Protons Selectively Regulate the Asymmetric Activation of the C─H Bonds of Methanol Molecules
ChemistrySelect,
Год журнала:
2025,
Номер
10(7)
Опубликована: Фев. 1, 2025
Abstract
The
activation
of
C─H
bonds
under
mild
conditions
is
a
crucial
step
in
the
conversion
organic
molecules.
However,
simultaneous
methanol
can
result
excessive
oxidation,
thereby
diminishing
selectivity
for
formaldehyde
production.
We
achieved
selective
by
adjusting
proton
concentration
an
anhydrous
solution,
which
significantly
enhanced
dehydrogenation
rate
methanol.
Additionally,
we
constructed
related
molecular
models
to
identify
sites
asymmetric
providing
new
insights
further
studies
on
bond
activation.
Язык: Английский
Multicomponent Cross-Dehydrogenative Coupling of Imidazo[1,2-a]pyridine: Access to Abnormal Mannich and Mannich-Type Reaction
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(15), С. 10773 - 10784
Опубликована: Июль 17, 2024
This
study
showcases
successfully
switchable
approaches
to
accomplish
the
C3-aryl
methylation
and
C3-
amino
of
privileged
nitrogen-containing
pharmaceutical
compounds
"imidazopyridines"
with
distinct
amines,
which
surmounts
long-standing
requirement
for
a
superfluous
directing
group.
These
two
transformations
manifest
pronounced
regio-
chemo-divergent
behavior,
demonstrating
unprecedented
multicomponent
"abnormal
Mannich
Mannich-type"
reactions.
The
remarkable
environmentally
benign
protocol
has
been
efficiently
extended
concise
synthesis
late-stage
derivatization.
Язык: Английский
Electrophotocatalytic Thiocyanation and Sulfonylation Cyclization of Unactivated Alkenes
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 18, 2024
We
report
an
electrophotocatalytic
process
that
enables
the
thiocyanation
and
sulfonylation/cyclization
of
alkenes.
It
is
applicable
to
a
wide
range
unactivated
alkenes,
using
inexpensive
photocatalyst
2,4,6-triphenylpyrylium
tetrafluoroborate
(TPPT)
produce
diverse
array
heterocycles
containing
sulfonyl
thiocyano
groups
with
good
functional
group
tolerance.
The
protocol
operates
under
mild,
chemical
oxidant-
transition-metal-free,
broad
scope
substrates.
Preliminary
mechanistic
studies
suggest
reaction
involves
combination
electrolysis
reductive
quenching
photocatalytic
cycle
TPPT.
Язык: Английский