Study on the correlation between circadian rhythm, intestinal flora and Liver stiffness in patients with Hepatic fibrosis
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 17, 2025
Abstract
Background:
Hepatic
fibrosis
(HF)
is
a
critical
pathological
process
in
chronic
liver
diseases,
and
its
progression
closely
associated
with
gut
microbiota
dysbiosis
circadian
rhythm
disruption.
However,
the
interplay
between
these
factors
HF
remains
poorly
understood.
This
study
aimed
to
investigate
relationship
composition,
disturbances,
HF,
providing
new
insights
into
potential
therapeutic
strategies.
Methods:
A
cross-sectional
was
conducted,
enrolling
patients
healthy
controls.
Liver
stiffness
measurement
(LSM)
assessed
using
transient
elastography.
Circadian
status
evaluated
Morningness-Eveningness
Questionnaire-5
(MEQ-5).
Gut
composition
analyzed
via
16S
rRNA
sequencing,
differences
microbial
diversity
taxa
abundance
were
compared
groups.
Correlation
analyses
performed
explore
associations
microbiota,
LSM,
rhythm.
Results:
Patients
exhibited
significant
alterations
at
both
phylum
genus
levels
(
p<0.05,
r
=
−
0.244).
The
relative
abundances
of
Escherichia-Shigella,
Klebsiella,
Pseudomonadota,
Ruminococcus
gnavus
group,
Enterocloster
significantly
increased,
while
Dorea,
Holdemanella,
[Ruminococcus]
gauvreauii
group,
[Eubacterium]
ventriosum
CAG-352,
Marvinbryantia
markedly
decreased.
These
shifts
enhanced
intestinal
inflammation
hepatic
immune
activation.
Notably,
Escherichia-Shigella
may
contribute
LPS-TLR4/inflammasome
activation,
inflammatory
cytokine
release,
reduced
short-chain
fatty
acid
(SCFA)
production.
Conversely,
SCFA-producing
bacteria
Firmicutes
showed
protective
role
by
mitigating
lipid
accumulation.
Furthermore,
disruption
negatively
correlated
an
increased
Mediterraneibacter
observed
disturbances.
As
known
produce
ethanol,
elevated
exacerbate
injury
inflammation,
potentially
contributing
development.
Conclusion:
reveals
association
dysbiosis,
disruption,
severity.
Our
findings
suggest
that
disturbances
influence
modulating
metabolic
activity.
highlight
strategies,
including
modulation
(e.g.,
light
therapy,
timed
medication)
microbiota-targeted
interventions,
slow
or
reverse
progression.
Язык: Английский
Recent advances in the role of polysaccharides in liver diseases: a review
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 27, 2025
Liver
diseases
are
a
serious
health
problem
worldwide,
especially
with
sustained
increase
in
the
burden
of
it
every
year.
However,
drugs
commonly
used
patients
have
limited
efficacy
and
adverse
reactions
associated
long-term
use.
Therefore,
is
urgent
to
find
effective
safe
alternatives.
Polysaccharides
currently
considered
promising
alternatives
traditional
because
their
extensive
activity
low
toxicity.
This
review
investigated
studies
on
hepatoprotective
polysaccharides
over
past
6
years,
detailing
effects,
potential
mechanisms,
drug
carrier
applications.
These
findings
suggest
that
prominent
preventive
therapeutic
effects
various
liver
such
as
drug-induced
injury,
alcoholic
disease,
hepatitis
B,
non-alcoholic
fatty
fibrosis,
hepatocellular
carcinoma.
Its
mechanism
includes
multiple
aspects
metabolic
regulation,
reduction
oxidative
stress
inflammation,
regulation
gut
microbiota.
Furthermore,
owing
good
physicochemical
properties,
been
applied
delivery
systems
for
chemotherapy
small
molecule
drugs.
further
research
essential
bioavailability,
structure-activity
relationship,
more
clinical
evidence
polysaccharides.
Continued
exploration
will
provide
tremendous
treatment
diseases.
Язык: Английский