Pyroptosis: mechanisms and diseases

Signal Transduction and Targeted Therapy, Год журнала: 2021, Номер 6(1)

Опубликована: Март 29, 2021

Abstract Currently, pyroptosis has received more and attention because of its association with innate immunity disease. The research scope expanded the discovery gasdermin family. A great deal evidence shows that can affect development tumors. relationship between tumors is diverse in different tissues genetic backgrounds. In this review, we provide basic knowledge pyroptosis, explain tumors, focus on significance tumor treatment. addition, further summarize possibility as a potential treatment strategy describe side effects radiotherapy chemotherapy caused by pyroptosis. brief, double-edged sword for rational use dual effect will help us explore formation ideas patients to develop new drugs based

Язык: Английский

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Anticancer activities of TCM and their active components against tumor metastasis

Biomedicine & Pharmacotherapy, Год журнала: 2020, Номер 133, С. 111044 - 111044

Опубликована: Дек. 13, 2020

Traditional Chinese Medicine (TCM) has the characteristics of multiple targets, slight side effects and good therapeutic effects. Good anti-tumor are shown by prescription, patent medicine, single medicine monomer compound. Clinically, TCM prolonged survival time patients improved life quality patients, due to less Cancer metastasis is a complex process involving numerous steps, genes their products. During tumor metastasis, firstly, cancer cell increases its proliferative capacity reducing autophagy apoptosis, then stimulated increasing ability tumors absorb nutrients from outside through angiogenesis. Both two steps can increase migration invasion. Finally, purpose achieved. By inhibiting apoptosis cells, angiogenesis EMT inhibit invasion cancer, consequently achieve metastasis. This review explores research achievements on breast lung hepatic carcinoma, colorectal gastric other in past five years, summarizes development direction years makes prospect for future.

Язык: Английский

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Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2

Theranostics, Год журнала: 2021, Номер 11(6), С. 2860 - 2875

Опубликована: Янв. 1, 2021

Hypoxia is commonly observed in solid tumors and contributes to the resistance of DNA damage drugs. However, mechanisms behind this are still unclear. In study, we aimed explore effects hypoxia-induced exosomes on non-small cell lung cancer (NSCLC). Methods: NSCLC cells were subjected either normoxic or hypoxic conditions assess survival changes expression levels key proteins. Comparative proteomics performed identify exosomal PKM2 cisplatin-resistant cells-derived exosomes. Functions hypoxia induced-exosomal promoting cisplatin evaluated both vitro vivo experiments molecular demonstrated using flow cytometry, immunoblotting, oxidative stress detection histological examination. A series evaluate function cancer-associated fibroblasts (CAFs). Results: exacerbated due increased that was secreted by cisplatin-resistance cells. We identified transmitted sensitive vivo. Mechanistically, promoted glycolysis produce reductive metabolites, which may neutralize reactive oxygen species (ROS) induced cisplatin. Additionally, inhibited apoptosis a PKM2-BCL2-dependent manner. Moreover, reprogrammed CAFs create an acidic microenvironment proliferation resistance. Conclusions: Our findings revealed transmit delivering PKM2. Exosomal serve as promising biomarker therapeutic target for NSCLC.

Язык: Английский

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Network pharmacology and molecular docking reveal the mechanism of Scopoletin against non-small cell lung cancer

Life Sciences, Год журнала: 2021, Номер 270, С. 119105 - 119105

Опубликована: Янв. 23, 2021

Язык: Английский

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Perspectives on the Role of Isoliquiritigenin in Cancer

Cancers, Год журнала: 2021, Номер 13(1), С. 115 - 115

Опубликована: Янв. 1, 2021

Isoliquiritigenin (2′,4′,4-trihydroxychalcone, ISL), one of the most important bioactive compounds with a chalcone structure, is derived from licorice root. Licorice commonly known as Glycyrrhiza, including Glycyrrhiza uralensis, radix, and glabra, which are generally available in common foods Chinese herbal medicines based on wide variety biological functions pharmacological effects, its derivative (ISL) utilized food additive adjunct disease treatment. In this review, we summarized progress over last 10 years targeted pathways molecular mechanisms ISL that involved regulation onset progression different types cancers.

Язык: Английский

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Unraveling the role of low‐density lipoprotein‐related genes in lung adenocarcinoma: Insights into tumor microenvironment and clinical prognosis

Environmental Toxicology, Год журнала: 2024, Номер 39(10), С. 4479 - 4495

Опубликована: Март 15, 2024

The hypothesized link between low-density lipoprotein (LDL) and oncogenesis has garnered significant interest, yet its explicit impact on lung adenocarcinoma (LUAD) remains to be elucidated. This investigation aims demystify the function of LDL-related genes (LRGs) within LUAD, endeavoring shed light complex interplay LDL carcinogenesis.

Язык: Английский

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Nano-Formulations for Pulmonary Delivery: Past, Present, and Future Perspectives

Pharmaceutics, Год журнала: 2024, Номер 16(2), С. 161 - 161

Опубликована: Янв. 24, 2024

With the development of nanotechnology and confronting problems traditional pharmaceutical formulations in treating lung diseases, inhalable nano-formulations have attracted interest. Inhalable for diseases allow precise pulmonary drug delivery, overcoming physiological barriers, improving aerosol deposition rates, increasing bioavailability. They are expected to solve difficulties faced diseases. However, limited success has been recorded industrialization translation nano-formulations. Only one relevant product approved by FDA date, suggesting that there still many issues be resolved clinical application These systems characterized a dependence on inhalation devices, while adaptability device formulation is inconclusive, which most important issue impeding translational research. In this review, we categorized various nano-formulations, summarized advantages over conventional formulations, listed undergoing studies. We focused influence devices analyzed their adaptability. After extensive analysis delivery mechanisms, technical processes, limitations different concluded vibrating mesh nebulizers might suitable delivering related examples were introduced validate our view. Finally, presented challenges outlook future development. anticipate providing an informative reference field.

Язык: Английский

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Gut microbiome affects the response to immunotherapy in non‐small cell lung cancer

Thoracic Cancer, Год журнала: 2024, Номер 15(14), С. 1149 - 1163

Опубликована: Апрель 4, 2024

Abstract Background Immunotherapy has revolutionized cancer treatment. Recent studies have suggested that the efficacy of immunotherapy can be further enhanced by influence gut microbiota. In this study, we aimed to investigate impact bacteria on effectiveness combining analysis clinical samples with validation in animal models. Methods order characterize diversity and composition microbiota its relationship response immune checkpoint inhibitors (ICIs), 16S ribosomal RNA (rRNA) GC–MS sequencing was performed 71 stool from patients advanced non‐small cell lung (NSCLC) prior treatment blockade (ICB). Furthermore, fecal transplantation (FMT) different into mice a subcutaneous tumor model established using Lewis line evaluate therapeutic effect PD‐1 varying Results The results demonstrated significant association between elevated ICIs, p < 0.05. Faecalibacterium markedly increased responders (R), accompanied short‐chain fatty acid (SCFA) levels, especially butanoic acid, acetic hexanoic Additionally, FMT R nonresponders (NR) could promote an anticancer reduce expression Ki‐67 cells tumors mice, Moreover, NR did not alter PD‐L1 tissues > consistently correlated optimistic prognosis NSCLC immunotherapy, which functionally mediated SCFAs. Conclusion findings present study indicated SCFAs is related immunotherapy. effectively delay progression, enhance thus providing evidence for improving patients.

Язык: Английский

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1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

Frontiers in Pharmacology, Год журнала: 2021, Номер 12

Опубликована: Июнь 11, 2021

Lung cancer is the most common malignancy and leads to around one-quarter of all deaths. Great advances have been achieved in treatment lung with novel anticancer agents improved technology. However, morbidity mortality rates remain extremely high, calling for an urgent need develop anti-lung agents. 1,2,3-Triazole could be readily interact diverse enzymes receptors organisms through weak interaction. can not only acted as a linker tether different pharmacophores but also serve pharmacophore. This review aims summarize recent 1,2,3-triazole-containing compounds potential, their structure-activity relationship (SAR) together mechanisms action discussed pave way further rational development candidates.

Язык: Английский

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Rationalizing the therapeutic potential of apigenin against cancer

Life Sciences, Год журнала: 2020, Номер 267, С. 118814 - 118814

Опубликована: Дек. 16, 2020

Язык: Английский

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