The efficiency of 18F-FDG PET-CT for predicting the major pathologic response to the neoadjuvant PD-1 blockade in resectable non-small cell lung cancer

European Journal of Nuclear Medicine and Molecular Imaging, Год журнала: 2020, Номер 47(5), С. 1209 - 1219

Опубликована: Фев. 11, 2020

Investigate whether 18F-FDG PET-CT has the potential to predict major pathologic response (MPR) neoadjuvant sintilimab in resectable NSCLC patients, and of sifting patients who probably benefit from immunotherapy. Treatment-naive with (stage IA–IIIB) received two cycles (200 mg, intravenously, day 1 22). Surgery was performed between 29 43. obtained at baseline prior surgery. The following lean body mass–corrected metabolic parameters were calculated by PET VCAR: SULmax, SULpeak, MTV, TLG, ΔSULmax%, ΔSULpeak%, ΔMTV%, ΔTLG%. responses classified using PERCIST. above information on FDG-PET correlated surgical pathology. (Registration Number: ChiCTR-OIC-17013726). Thirty-six 2 doses sintilimab, all whom underwent twice had radical resection (35) or biopsy (1). MPR occurred 13 36 resected tumors (36.1%, 13/36). degree pathological regression positively SULmax (p = 0.036) scan-1, negatively scan-2, percentage changes after therapy < 0.05). According PERCIST, 13/36) showed partial (PMR), 21 (58.3%, 21/36) stable disease, (5.6%, 2/36) progressive disease (PMD). There a significant correlation which All (100.0%) PMR (ΔSULpeak% − 30.0%) MPR. can non-small cell lung cancer.

Язык: Английский

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Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer: A signature step hinting towards clinical perfection

Translational Oncology, Год журнала: 2022, Номер 27, С. 101596 - 101596

Опубликована: Дек. 5, 2022

Cancer prevalence and its rate of incidence are constantly rising since the past few decades. Owing to toxicity present-day antineoplastic drugs, it is imperative explore safer more effective molecules combat and/or prevent this dreaded disease. Flavonoids, a class polyphenols, have exhibited multifaceted implications against several diseases including cancer, without showing significant towards normal cells. Shredded pieces evidence suggest that flavonoids can enhance drug sensitivity suppress proliferation, metastasis, angiogenesis cancer cells by modulating oncogenic or oncosuppressor microRNAs (miRNAs, miRs). They play pivotal roles in regulation various biological pathological processes, cancers. In present review, structure, chemistry miR targeting efficacy quercetin, luteolin, silibinin, genistein, epigallocatechin gallate, cyanidin types comprehensively discussed. miRs considered as next-generation medicine recent times, their naturally occurring could be deemed signature step. We anticipate our compilations related miRNA-mediated might catapult clinical investigations affirmation future.

Язык: Английский

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CXCL13-CXCR5 axis: Regulation in inflammatory diseases and cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2022, Номер 1877(5), С. 188799 - 188799

Опубликована: Сен. 1, 2022

Chemokine C-X-C motif ligand 13 (CXCL13), originally identified as a B-cell chemokine, plays an important role in the immune system. The interaction between CXCL13 and its receptor, G-protein coupled receptor (GPCR) CXCR5, builds signaling network that regulates not only normal organisms but also development of many diseases. However, precise action mechanism remains unclear. In this review, we discussed functional mechanisms CXCL13-CXCR5 axis under conditions, with special focus on association For certain refractory diseases, emphasize diagnostic therapeutic axis.

Язык: Английский

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Hypoxic lung cancer cell-derived exosomal miR-21 mediates macrophage M2 polarization and promotes cancer cell proliferation through targeting IRF1

World Journal of Surgical Oncology, Год журнала: 2022, Номер 20(1)

Опубликована: Июль 27, 2022

Hypoxia is the hallmark of tumor microenvironment (TME) and plays a critical role during progress development. A variety microRNAs (miRNAs) transmitted by tumor-derived exosomes were involved in intercellular communication. We aimed to elucidate precise mechanism which cell-derived promote lung cancer development affecting macrophage polarization under hypoxic conditions.CD163 signal tissue from patients was detected immunohistochemical (IHC). The M2 polarization-related markers assessed flow cytometry western blot. Exosomes isolated normoxic cell culture characterized transmission electron microscope (TEM), dynamic light scattering (DLS), RNA sequencing performed show abnormally expressed miRNAs culture. In addition, CCK-8 clone formation assays used assess proliferation. Dual luciferase reporter assay evaluate relationship between miR-21 IRF1. For vivo experiment, male nude mice injected with H1299 cells mimic treatment.Firstly, we found strong CD163 IHC. Subsequently, co-cultured line M0 THP-1 that environment promoted polarization. PKH67 fluorescence staining experiments confirmed origin able enter induced showed level significantly higher group compared group. Subsequent cellular inhibited expression IRF1 targeting it. overexpression reversed on Finally, have through animal either or high progression.High environments progression

Язык: Английский

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ROS and Endoplasmic Reticulum Stress in Pulmonary Disease

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Апрель 26, 2022

Pulmonary diseases are main causes of morbidity and mortality worldwide. Current studies show that though specific pulmonary correlative lung-metabolic deviance own unique pathophysiology clinical manifestations, they always tend to exhibit common characteristics including reactive oxygen species (ROS) signaling disruptions proteostasis bringing about accumulation unfolded or misfolded proteins in the endoplasmic reticulum (ER). ER is generated by protein response. When adaptive response (UPR) fails preserve homeostasis, a maladaptive terminal UPR engaged, leading disruption integrity apoptosis, which called stress. The stress mainly includes lumen disorder Ca 2+ balance. ROS mediates several critical aspects We summarize latest advances pathogenesis disease discuss potential therapeutic strategies aimed at restoring disease.

Язык: Английский

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Baicalein: A review on its anti‐cancer effects and mechanisms in lung carcinoma

Journal of Food Biochemistry, Год журнала: 2022, Номер 46(9)

Опубликована: Май 11, 2022

Plant-derived flavonoids are reported to function as potential anti-cancer agents against different types of cancer. Baicalein (BE) is an important flavonoid found in the roots Scutellaria baicalensis that popularly used Chinese medicine ingredient herbal tea preparations promote wellness. BE has been studied for its several biological effects including antioxidant, anti-inflammatory, anti-hepatotoxic, antiviral, and anti-tumor properties. now discovered be effective agent lung neoplasm. The molecular factors supporting baicalein's activity cancer value human health discussed this article. This would help identifying a promising competent drug carcinoma. Practical applications obtained from baicalensis. It widely anti-inflam5matory, agent. Lung one most common malignancies world with high fatality rate. Several studies have candidate treating Its mechanism action includes regulation cell proliferation, metastasis, apoptosis, autophagy, so on. could novel treatment

Язык: Английский

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Deep Learning-Based Bioactive Therapeutic Peptide Generation and Screening

Journal of Chemical Information and Modeling, Год журнала: 2023, Номер 63(3), С. 835 - 845

Опубликована: Фев. 1, 2023

Many bioactive peptides demonstrated therapeutic effects over complicated diseases, such as antiviral, antibacterial, anticancer, etc. It is possible to generate a large number of potentially using deep learning in manner analogous the generation de novo chemical compounds acquired training set. Such generative techniques would be significant for drug development since are much easier and cheaper synthesize than compounds. Despite limited availability learning-based peptide-generating models, we have built an LSTM model (called LSTM_Pep) fine-tuned with specific prospective benefits. Remarkably, Antimicrobial Peptide Database has been effectively utilized various kinds potential active peptides. We proposed pipeline screening those generated given target used main protease SARS-COV-2 proof-of-concept. Moreover, developed protein–peptide prediction (DeepPep) rapid targets. Together generating model, that iteratively fine-tuning training, generating, higher-predicted binding affinity can achieved. Our work sheds light on developing methods pipelines obtain effect showcases how artificial intelligence help discover bind particular target.

Язык: Английский

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Metal Oxide Semiconductor Gas Sensors for Lung Cancer Diagnosis

Chemosensors, Год журнала: 2023, Номер 11(4), С. 251 - 251

Опубликована: Апрель 17, 2023

Lung cancer is the most prevalent severe illness in both sexes and all ages leading cause of cancer-related deaths globally. Late-stage diagnosis primary its high mortality rate. Therefore, management lung needs early-stage screening. Breath analysis a non-invasive, low-cost, user-friendly approach to diagnosing cancer. Among various types breath sensors, MOS gas sensors are preferred due their responses, fast response times, robustness, lower price. This review focuses on critical role detecting VOCs patients’ exhaled breath. It introduces basic working mechanism gas-sensitive materials, summarizes some high-performance materials suitable for potential biomarkers provides performance enhancement strategies. The also briefly sensor array pattern recognition algorithm. Finally, we discuss challenges developing screening present prospect using e-nose large-scale early

Язык: Английский

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New insights into the function of Interleukin-25 in disease pathogenesis

Biomarker Research, Год журнала: 2023, Номер 11(1)

Опубликована: Апрель 1, 2023

Abstract Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family. IL-25 abundantly expressed by Th2 cells and various kinds of epithelial cells. an alarm signal generated upon cell injury or tissue damage activate immune through interaction with IL-17RA IL-17RB receptors. The binding IL-17RA/IL-17RB complex not only initiates maintains type 2 immunity but regulates other (e.g., macrophages mast cells) via signaling pathways. It has been well-documented that critically involved in development allergic disorders asthma). However, roles pathogenesis diseases underlying mechanisms are still unclear. This review presents current evidence on cancers, disorders, autoimmune diseases. Moreover, we discuss unanswered key questions IL-25-mediated disease pathology, which will provide new insights into targeted therapy this clinical treatment.

Язык: Английский

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Sensing properties and mechanisms of LaF3–Co3O4 nanorods for low-concentration methanol detection

Rare Metals, Год журнала: 2024, Номер 43(5), С. 2193 - 2204

Опубликована: Фев. 6, 2024

Язык: Английский

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