Gene age shapes functional and evolutionary properties of theDrosophilaseminal fluid proteome DOI Creative Commons
José M. Ranz,

Carolina Flacchi,

Imtiyaz Hariyani

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 20, 2024

Abstract Seminal fluid proteins (Sfps) are crucial for animal reproductive success, with most Sfps-encoding genes believed to be evolutionarily young and rapidly evolving. By employing estimates of the phylogenetic origin each Drosophila melanogaster Sfp gene based on genomic resources that include outgroup species genus, we examined functional attributes evolutionary characteristics relative their age. Contrary common belief, 62% existed in genome ancestor such genus. These ancient have broadened expression profiles, expanded biological roles, formed a denser network interactions non-Sfp genes. This increased pleiotropy has imposed constraints rate sequence evolution compared younger ones. Within interactome, identified fast-evolving core sub-network more restricted tissue functions. Our findings uncover large, previously unrecognized set distinct genomic, functional, younger, commonly studied

Язык: Английский

Regional specialization, polyploidy, and seminal fluid transcripts in the Drosophila female reproductive tract DOI Creative Commons
Rachel C. Thayer, Elizabeth S. Polston,

Jixiang Xu

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(44)

Опубликована: Окт. 25, 2024

Sexual reproduction requires the choreographed interaction of female cells and molecules with sperm seminal fluid. In internally fertilizing animals, these interactions are managed by specialized tissues within reproductive tract (FRT), such as a uterus, glands, storage organs. However, somatic remain understudied, hindering insight into molecular that support fertility. Here, we report identification, characterization, analysis cell types throughout FRT in premier

Язык: Английский

Процитировано

2
Gene age shapes functional and evolutionary properties of theDrosophilaseminal fluid proteome DOI Creative Commons
José M. Ranz,

Carolina Flacchi,

Imtiyaz Hariyani

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 20, 2024

Abstract Seminal fluid proteins (Sfps) are crucial for animal reproductive success, with most Sfps-encoding genes believed to be evolutionarily young and rapidly evolving. By employing estimates of the phylogenetic origin each Drosophila melanogaster Sfp gene based on genomic resources that include outgroup species genus, we examined functional attributes evolutionary characteristics relative their age. Contrary common belief, 62% existed in genome ancestor such genus. These ancient have broadened expression profiles, expanded biological roles, formed a denser network interactions non-Sfp genes. This increased pleiotropy has imposed constraints rate sequence evolution compared younger ones. Within interactome, identified fast-evolving core sub-network more restricted tissue functions. Our findings uncover large, previously unrecognized set distinct genomic, functional, younger, commonly studied

Язык: Английский

Процитировано

0