Implication of protein post translational modifications in gastric cancer

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Фев. 4, 2025

Gastric cancer (GC) is one of the most common and highly lethal malignant tumors worldwide, its occurrence development are regulated by multiple molecular mechanisms. Post-translational modifications (PTM) forms include ubiquitylation, phosphorylation, acetylation methylation. Emerging research has highlighted lactylation glycosylation. The diverse realm PTM crosstalk linked to many critical signaling events involved in neoplastic transformation, carcinogenesis metastasis. This review provides a comprehensive overview impact on progression GC. Specifically, aberrant have been shown alter proliferation, migration, invasion capabilities GC cells. Moreover, closely associated with resistance chemotherapeutic agents Notably, this also discusses phenomenon crosstalk, highlighting interactions among their roles regulating pathways protein functions. Therefore, in-depth investigation into mechanisms targeted therapeutic strategies hold promise for advancing early diagnosis, treatment, prognostic evaluation GC, offering novel insights future directions.

Язык: Английский

From Discovery to Implementation: Bringing Proteomics to the Clinic

PROTEOMICS, Год журнала: 2025, Номер unknown

Опубликована: Май 20, 2025

Язык: Английский

In Search of Candidate Protein Biomarkers Related to COVID‐19 in Solid Tissues and Non‐Blood Fluids: An Update

PROTEOMICS - CLINICAL APPLICATIONS, Год журнала: 2024, Номер unknown

Опубликована: Дек. 30, 2024

During COVID-19, significant changes in protein abundance can be linked with disease-related processes. The mass spectrometry-based proteomics of COVID-19-related biomarkers help the prognosis and diagnosis this severe disease.

Язык: Английский