Investigating causal relationships between plasma proteins and lung adenocarcinoma: result from proteomics and Mendelian randomization study DOI Creative Commons

Ruo-Ya Lv,

Jiabin Chen, Xiaoyu Wu

и другие.

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 13, 2025

Plasma proteins contribute to the identification, diagnosis, and prognosis of human illnesses, which may be conducive understanding molecular mechanism diagnosis Lung adenocarcinoma (LUAD). We collected plasma samples from 28 healthy individuals (H) 56 LUAD patients analyzed them using LC–MS/MS-based proteomics determine differential expression (DEPPs). Then, DEPPs were subjected a two-sample Mendelian randomization (MR) study based on an "Inverse variance weighted (IVW)" approach investigate causal relationships between LUAD. Logistic regression analysis was conducted develop diagnostic model for 317 found in proteomics, 19 identified. The MR revealed that IL20RB (odds ratio (OR) = 1.600, 95% Confidence Interval (CI) [1.098, 2.331], P 0.014) SAA2 (OR 1.048, 95%CI [1.012, 1.081], 0.017) highly related A established with SAA2. AUC this 0.858. levels closely connected

Язык: Английский

Investigating causal relationships between plasma proteins and lung adenocarcinoma: result from proteomics and Mendelian randomization study DOI Creative Commons

Ruo-Ya Lv,

Jiabin Chen, Xiaoyu Wu

и другие.

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 13, 2025

Plasma proteins contribute to the identification, diagnosis, and prognosis of human illnesses, which may be conducive understanding molecular mechanism diagnosis Lung adenocarcinoma (LUAD). We collected plasma samples from 28 healthy individuals (H) 56 LUAD patients analyzed them using LC–MS/MS-based proteomics determine differential expression (DEPPs). Then, DEPPs were subjected a two-sample Mendelian randomization (MR) study based on an "Inverse variance weighted (IVW)" approach investigate causal relationships between LUAD. Logistic regression analysis was conducted develop diagnostic model for 317 found in proteomics, 19 identified. The MR revealed that IL20RB (odds ratio (OR) = 1.600, 95% Confidence Interval (CI) [1.098, 2.331], P 0.014) SAA2 (OR 1.048, 95%CI [1.012, 1.081], 0.017) highly related A established with SAA2. AUC this 0.858. levels closely connected

Язык: Английский

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