Journal of Microencapsulation, Год журнала: 2024, Номер unknown, С. 1 - 12
Опубликована: Дек. 23, 2024
Plant-derived extracellular vesicles (EVs) are natural nanovesicles for drug delivery. This study isolated and characterised EVs from medicinal plants as delivery vehicles.
Язык: Английский
Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(1), С. 24 - 24
Опубликована: Янв. 14, 2025
Autoimmune diseases present complex therapeutic challenges due to their chronic nature, systemic impact, and requirement for precise immunomodulation avoid adverse side effects. Recent advancements in biodegradable stimuli-responsive nanomaterials have opened new avenues targeted drug delivery systems capable of addressing these challenges. This review provides a comprehensive analysis state-of-the-art nanocarriers such as polymeric nanoparticles, liposomes, hydrogels engineered autoimmune therapies. These are designed degrade safely the body while releasing agents response specific stimuli, including pH, temperature, redox conditions, enzymatic activity. By achieving localized controlled release anti-inflammatory immunosuppressive agents, minimize toxicity enhance efficacy. We discuss underlying mechanisms nanomaterials, recent applications treating rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, design considerations essential clinical translation. Additionally, we address current challenges, biocompatibility, scalability, regulatory hurdles, well future directions integrating advanced nanotechnology with personalized medicine treatment. highlights transformative potential presenting them promising strategy advance precision improve patient outcomes disease management.
Язык: Английский
Процитировано
2
The Science of The Total Environment, Год журнала: 2024, Номер 925, С. 171774 - 171774
Опубликована: Март 18, 2024
Язык: Английский
Процитировано
14
Small, Год журнала: 2024, Номер 20(43)
Опубликована: Июль 14, 2024
This review explores the evolution of lipid-based nanoparticles (LBNPs) for drug delivery (DD). Herein, LBNPs are classified into liposomes and cell membrane-based (CMNPs), each with unique advantages challenges. Conventional possess drawbacks such as poor targeting, quick clearance, limited biocompatibility. One possible alternatives to overcome these challenges is surface modification (NPs) materials polyethylene glycol (PEG), aptamers, antibody fragments, peptides, CD44, hyaluronic acid, folic palmitic lactoferrin. Thus, main focus this will be on different modifications that enable have beneficial properties DD, enhancing mass transport properties, immune evasion, improved stability, targeting. Moreover, various CMNPs explored used DD derived from cells red blood (RBCs), platelets, leukocytes, cancer cells, stem highlighting their natural (e.g., biocompatibility ability evade system). discussion extends biomimicking hybrid NPs accomplished through coating synthetic (mainly polymeric) membranes. aims provide a comprehensive resource researchers recent advances in field CMNPs. Overall, provides valuable insights dynamic systems.
Язык: Английский
Процитировано
11
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 178, С. 117248 - 117248
Опубликована: Авг. 3, 2024
Exosome-nanoparticle hybrid nanoplatforms, can be prepared by combining exosomes with different types of nanoparticles. The main purpose nanoparticles is to overcome the limitations using each them as drug delivery systems. Using for has some limitations, such high immunogenicity, poor cellular uptake, low biocompatibility, cytotoxicity, stability, and rapid clearance immune cells. However, systems also its own drawbacks, encapsulation efficiency, production yield, inability load large molecules. These addressed utilizing nanoplatforms. Additionally, use allows targeted within system. Exosome-inorganic/organic may used both therapy diagnosis in future. This lead development personalized medicine there are a few challenges associated this. Surface modifications, adding functional groups, surface charge adjustments, preparing desired size crucial possibility exosome-nanoparticle hybrids. Additional successful implementation platforms medical treatments diagnostics include scaling up manufacturing process ensuring consistent quality reproducibility across various batches. review focuses on discusses preparation loading methods these Furthermore, potential applications nanocarriers drug/gene delivery, disease treatment diagnosis, cell/tissue imaging explained.
Язык: Английский
Процитировано
9
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Янв. 19, 2024
Mycobacterium tuberculosis ( M.tb ) effectively manipulates the host processes to establish deadly respiratory disease, Tuberculosis (TB). has developed key mechanisms disrupt cell health combat immune responses and replicate efficaciously. antigens such as ESAT-6, 19kDa lipoprotein, Hip1, Hsp70 destroy integrity of organelles (Mitochondria, Endoplasmic Reticulum, Nucleus, Phagosomes) or delay innate/adaptive responses. This is followed by induction cellular stress in host. Such cells can either undergo various death apoptosis necrosis, mount effective clear invading pathogen. Further, infection progression, secretes extracellular vesicles exosomes initiate signaling. The contain well cell-derived peptides that act a double-edged sword signaling event. host-symbiont microbiota produces metabolites are beneficial for maintaining healthy tissue microenvironment. In juxtaposition above-mentioned mechanisms, dysregulates gut microbiome support its replication dissemination process. interconnected Immunometabolism, Cellular stress, Host Microbiome, Extracellular less explored realm exploration novel Host-directed therapies TB. Therefore, this review highlights intertwined control survival showcases important factors be targeted designing efficacious therapy.
Язык: Английский
Процитировано
6
Extracellular Vesicle, Год журнала: 2024, Номер 3, С. 100044 - 100044
Опубликована: Май 13, 2024
Spinal cord injury (SCI) is the damage to spinal causing paralysis below site compromised patient life quality. Exosomes are nanosized vesicles released during physiological or pathological processes. They present a promising avenue for therapeutic drug delivery due their tissue specificity and biocompatibility, offering enhanced efficacy with reduced accumulation-based toxicity. In SCI, exosomes target inflammation, apoptosis, microglial polarization, autophagy, contributing interventions. This article comprehensively explores pathophysiology of diverse exosome synthesis processes, limitations challenges overcome, potential from various cellular sources in SCI treatment.
Язык: Английский
Процитировано
4
Neurochemical Research, Год журнала: 2025, Номер 50(2)
Опубликована: Янв. 30, 2025
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101613 - 101613
Опубликована: Фев. 25, 2025
Язык: Английский
Процитировано
0
Brain Research, Год журнала: 2025, Номер unknown, С. 149590 - 149590
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Cancer Cell International, Год журнала: 2025, Номер 25(1)
Опубликована: Апрель 15, 2025
Abstract Brain cancer remains a significant challenge in the field of oncology, primarily because its aggressive nature and limited treatment options available. Conventional therapies often fall short effectively targeting tumor cells, while sparing healthy brain tissue from collateral damage. However, exosomes are now recognized as promising nanocarriers for targeted drug delivery. These naturally occurring extracellular vesicles can cross blood–brain barrier selectively interact with cells. Utilizing delivery vehicles offers novel approach potential therapy. By encapsulating therapeutic agents within exosomes, drugs be specifically to maximizing their impact whilst minimizing damage tissue. Furthermore, modified display molecules that recognize bind further enhancing precision efficacy. While exosome-based show potential, scalability, purification, clinical application challenges remain. The scalability exosome production, modification techniques hurdle must overcome translation. Additionally, intricate interactions between microenvironment necessitate research optimize outcomes. review explores applications future perspectives advancing treatment.
Язык: Английский
Процитировано
0