Scientia Pharmaceutica,
Год журнала:
2024,
Номер
93(1), С. 1 - 1
Опубликована: Дек. 24, 2024
Colon
cancer
(CC)
is
the
third
most
frequent
neoplasm,
with
a
considerably
high
mortality
rate.
Due
to
side
effects
of
conventional
forms
CC
treatment
(surgery,
chemotherapy,
and
radiotherapy),
several
studies
have
focused
on
use
medicinal
plant
derivatives
provide
green
therapy
for
CC;
although
phytochemicals
shown
promising
results
against
CC,
translating
obtained
in
vitro
vivo
clinical
setting
remains
challenge.
Indeed,
like
other
orally
applied
medicines,
cross
different
physiological
barriers
reach
microenvironment,
which
limits
their
dose-dependent
therapeutic
efficacy.
On
hand,
phytocompounds
are
not
free
from
biopharmaceutical
drawbacks,
so
novel
strategies
using
nanoparticles
(NPs)
been
proposed
overcome
body
controlled
release
actives
interest.
Accordingly,
current
review
provides
an
overview
discussion
predisposing
factors
treatment,
plants
advantages
provided
by
NPs
CC.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 231 - 231
Опубликована: Фев. 8, 2025
Colorectal
cancer
(CRC)
represents
one
of
the
most
serious
health
issues
and
third
commonly
diagnosed
worldwide.
However,
treatment
options
for
CRC
are
associated
with
adverse
reactions,
in
some
cases,
resistance
can
develop.
Flavonoids
have
emerged
as
promising
alternatives
prevention
therapy
due
to
their
multitude
biological
properties
ability
target
distinct
processes
involved
pathogenesis.
Their
innate
disadvantageous
(e.g.,
low
solubility
stability,
reduced
bioavailability,
lack
tumor
specificity)
delayed
potential
inclusion
flavonoids
regimens
but
hastened
design
nanopharmaceuticals
comprising
a
flavonoid
agent
entrapped
nanosized
delivery
platform
that
not
only
counteract
these
inconveniences
also
provide
an
augmented
therapeutic
effect
elevated
safety
profile
by
conferring
targeted
action.
Starting
brief
presentation
pathological
features
overview
classes,
present
study
comprehensively
reviews
anti-CRC
activity
different
from
mechanistic
perspective
while
portraying
latest
discoveries
made
area
flavonoid-containing
nanocarriers
proved
efficient
management.
This
review
concludes
showcasing
future
perspectives
advancement
flavonoid-based
research.
Journal of Materials Science Materials in Medicine,
Год журнала:
2025,
Номер
36(1)
Опубликована: Март 5, 2025
Oral
drug
administration
is
the
preferred
route
for
pharmaceuticals,
accounting
~90%
of
global
pharmaceutical
market
due
to
its
convenience
and
cost-effectiveness.
This
study
provides
a
comprehensive
scientific
technological
analysis
latest
advances
in
oral
dosage
forms
colon-targeted
delivery.
Utilizing
patent
databases,
along
with
bibliometric
bibliographical
review,
we
compared
(technology)
specific
application
technology
(colon
delivery)
using
four
search
equations.
Our
findings
reveal
gap
publications
inventions
associated
colon
release
general
applications.
While
tablets
capsules
were
found
most
used
forms,
other
platforms
such
as
nanoparticles,
microparticles,
emulsions
have
been
also
explored.
Enteric
coatings
are
frequently
applied
excipient
prevent
early
stomach
pH-triggered
systems
being
predominant
mechanism.
In
summary,
this
review
last
advancements
high-impact
resources
development
delivery,
providing
insights
into
maturity
these
approaches.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2025,
Номер
unknown, С. 1 - 23
Опубликована: Март 6, 2025
Studies
have
indicated
that
milk
extracellular
vesicles
(EVs)
are
resistant
to
both
the
enzymatic
activity
of
digestive
enzymes
and
acidic
conditions
common
in
gastrointestinal
tract.
Thus,
intestinal
tract
efficiently
absorbs
uses
these
EVs.
There
is
mounting
evidence
recent
years
microRNAs
(miRNAs)
found
EVs
derived
from
essential
for
prebiotic
effect
through
target
gene
regulation.
In
this
paper,
we
summarized
sources,
biosynthetic
processes,
cargos,
factors
affecting
milk-derived
Furthermore,
with
particular
attention
potential
communication
mechanism
cell
receptors,
including
recognizing
binding
surface
receptor
cells,
internalization
uptake,
cargos
acting
on
cells.
Especially,
also
explored
role
several
aspects
health,
such
as
immunological
homeostasis,
barrier,
injury,
inflammatory
bowel
disease,
necrotizing
enterocolitis,
malignancy,
harm
other
organs
connected
intestine.
We
expected
use
or
miRNAs
new
dietary
additives
functional
regulatory
factors.
future,
will
gain
more
knowledge
about
substantial
impact
human
intestines
health-related
matters.
Beni-Suef University Journal of Basic and Applied Sciences,
Год журнала:
2025,
Номер
14(1)
Опубликована: Март 25, 2025
Abstract
Background
There
is
no
doubt
that
one
of
the
most
considerable
researcher
dilemmas
cancer.
Radiofrequency-photodynamic
therapy
(RFPDT)
offers
novel
approaches
to
cancer
treatment
by
combining
radiofrequency-dynamic
and
photodynamic
with
sensitizers.
While
sensitizers
for
RFPDT
have
been
synthesized
successfully,
their
effective
application
still
limited.
Their
limited
ability
transfer
sensitizer's
deeper
intratumorally,
low
tumor-targeting
selectivity,
failing
tumor
microenvironment
all
restrict
anti-tumor
activity.
The
goal
current
work
was
examine
recent
advancement
in
activated
using
radiofrequency
assisted
drug
delivery
conjugated
carbon
nanoparticles
broccoli,
cabbage,
kale
(BCK-ACNP)
treat
colorectal
(CRCA)
both
vivo
vitro
RFPDT.
Materials
methods
study
included
human
CRCA
cells
(SW-620)
Swiss
albino
induce
mice
[treated
1,2-dimethylhydrazine
(DMH)
dextran
sulphate
sodium
(DSS)
only]
were
used
study.
protocol
started
only
after
induction,
involved
daily
administration
BCK-ACNP
as
sensitizer
whether
or
not
be
exposed
laser
(IRL)
(RF)
a
combination
them
3
min
period
2
weeks.
Results
Demonstrated
ACNP
useful
BCK
mechanism
targets
directly.
Furthermore,
promising
RFPS
that,
when
conjunction
RFPDT,
can
very
treating
CRCA-SW-620
(in
dose-dependent
manner
cell
viability
declined,
an
increase
population
during
S
G2/M
phases
indicates
cycle
arrested,
Pre-G
population,
autophagic
death,
well
early
late
apoptosis
necrosis,
indicate
death
induced)
DMH/DSS-CRCA-induced
(induced
antiproliferative
genes,
p53,
Bax,
TNFalpha,
caspase
3,9,
repressed
antiangiogenic
antiapoptotic
VEGF
Bcl2
respectively),
successfully
slowing
growth
tumors
even
killing
cells,
lowering
oxidative
stress
(MDA),
improving
functions
kidneys
(urea,
creatinine),
liver
(ALT,
AST),
antioxidants
(GPx,
GR,
GST,
GSH,
CAT,
SOD,
TAC).
photochemical
activation
mechanism,
antioxidant
capacity
non-activated
linked
this
process.
Conclusion
Based
on
findings,
shows
great
promise
cutting-edge,
efficient
selective
system
localized
RFPDT-activated
treatment.
Zahedan Journal of Research in Medical Sciences,
Год журнала:
2024,
Номер
27(1)
Опубликована: Дек. 17, 2024
Context:
Nanotechnology,
specifically
nanoparticles,
has
revolutionized
cancer
therapy
through
enhanced
drug
delivery,
precise
imaging,
and
accurate
diagnosis.
Their
ability
to
target
cells
directly
with
minimal
side
effects
makes
them
especially
promising
for
treating
colorectal
(CRC),
allowing
more
effective
treatments.
Methods:
A
systematic
literature
review
was
conducted
across
multiple
databases
(PubMed,
Scopus,
Embase,
Cochrane,
Web
of
Science,
Google
Scholar)
using
MeSH
terms
such
as
cancer,
cells.
The
objectives
this
were
examine
the
effectiveness
nanoparticle-based
delivery
systems,
evaluate
their
targeting
mechanisms,
assess
impact
on
treatment
outcomes
CRC.
Study
eligibility,
participant
inclusion
criteria,
specific
intervention
types
critically
analyzed
ensure
a
comprehensive
understanding.
Results:
Nanoparticle-based
systems
have
demonstrated
significant
promise
in
shrinking
tumors,
improving
accumulation
at
tumor
site,
facilitating
easier
surgical
removal.
These
enhance
efficacy,
reduce
toxicity,
overcome
biological
barriers
CRC,
particularly
use
pH-responsive
thermoresponsive
nanoparticles.
Conclusions:
application
nanoparticles
represents
safe
option,
demonstrating
improved
targeting,
reduced
effects,
therapeutic
outcomes.
However,
further
research
is
necessary
long-term
safety,
scalability
these
alongside
optimization
clinical
personalized
