Chimeric antigen receptor T-cell therapy in autoimmune diseases
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 19, 2024
The
administration
of
T
cells
that
have
been
modified
to
carry
chimeric
antigen
receptors
(CARs)
aimed
at
B
has
an
effective
strategy
in
treating
cell
malignancies.
This
breakthrough
spurred
the
creation
CAR
intended
specifically
reduce
or
alter
faulty
immune
responses
associated
with
autoimmune
disorders.
Early
positive
outcomes
from
clinical
trials
involving
target
protein
CD19
patients
suffering
diseases
driven
by
reported.
Additional
strategies
are
being
developed
broaden
use
therapy
and
enhance
its
safety
conditions.
These
include
employing
autoantireceptors
(CAAR)
eliminate
reactive
autoantigens,
using
regulatory
(Tregs)
engineered
antigen-specific
CARs
for
precise
modulation.
discussion
emphasizes
key
factors
such
as
choosing
right
groups,
designing
constructs,
defining
tolerable
side
effects,
achieving
a
lasting
modification,
all
which
critical
safely
integrating
diseases.
Язык: Английский
CAR-T Therapy can be a Useful Treatment Modality for more than Just Hematologic Malignancies
Internal Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Chimeric
antigen
receptor-T-cell
(CAR-T)
therapy
for
hematologic
malignancies
has
made
significant
advancements
over
the
years,
and
it
is
now
incorporated
as
a
treatment
algorithm.
Early
phase
clinical
trials
are
underway
various
solid
tumors,
effectiveness
of
CAR-T
cell
been
demonstrated
specific
types
glioma
several
tumors.
However,
its
efficacy
does
not
match
that
observed
in
hematological
malignancies.
Recently,
case
series
reported
targeting
CD19
autoimmune
diseases
such
systemic
lupus
erythematosus,
leading
to
dramatic
improvement
symptoms
possibility
discontinuing
immunosuppressive
agents.
Furthermore,
expected
be
effective
against
viruses
Aspergillus
spp.
Finally,
attempts
have
introduce
CAR
constructs
into
regulatory
T
cells
target
their
effects.
This
article
introduces
current
progress
beyond
only
discusses
future
directions,
considering
medical
situation
Japan.
Язык: Английский