Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1461 - 1461
Опубликована: Ноя. 28, 2024
Low
molecular
weight
(LMW)
thiols,
particularly
glutathione,
play
pathogenic
roles
in
various
multiorgan
diseases.
The
liver
is
central
for
the
production
and
systemic
distribution
of
LMW
thiols;
thus,
it
susceptible
to
imbalance
redox
status
that
may
determine
increased
oxidative
stress
trigger
damage
observed
metabolic
dysfunction-associated
steatotic
disease
(MASLD)
models
humans.
Indeed,
thiols
at
cellular
extracellular
levels
be
associated
with
severity
MASLD.
Here,
we
present
a
systematic
literature
review
recent
studies
assessing
MASLD
vivo
vitro
human
subjects.
Based
on
PRISMA
2020
criteria,
search
was
conducted
using
PubMed
Scopus
by
applying
inclusion/exclusion
filters.
initial
returned
1012
documents,
from
which
165
eligible
were
selected,
further
described,
qualitatively
analysed.
Of
these
studies,
most
focused
animal
models,
while
minority
used
fluids.
analysis
revealed
heterogeneity
methods
sample
processing
measurement
thiol
levels,
hinder
cut-off
values
diagnostic
use.
Standardisation
measure
necessary
facilitate
future
studies.
Metabolites,
Год журнала:
2025,
Номер
15(5), С. 287 - 287
Опубликована: Апрель 24, 2025
Background/Objectives:
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD),
previously
known
as
non-alcoholic
fatty
(NAFLD),
is
rapidly
becoming
the
most
prevalent
form
of
chronic
in
both
pediatric
and
adult
populations.
It
encompasses
a
wide
spectrum
abnormalities,
ranging
from
simple
fat
accumulation
to
severe
conditions
such
inflammation,
fibrosis,
cirrhosis,
cancer.
Major
risk
factors
for
MASLD
include
obesity,
insulin
resistance,
type
2
diabetes,
hypertriglyceridemia.
Methods:
This
narrative
review
employed
comprehensive
search
recent
literature
identify
latest
studies
on
relationship
between
MAFLD
health
consequences
treatment
options
prevent
long-term
damage
other
organs.
Additionally,
article
presents
perspectives
diagnostic
biomarkers.
Results:
Childhood
obesity
linked
multitude
comorbid
remains
primary
factor
obesity.
abnormal
have
detrimental
effects
into
adulthood.
Scientific
evidence
unequivocally
demonstrates
role
obesity-related
conditions,
dyslipidemia,
hyperglycemia,
development
progression
MASLD.
Oxidative
stress,
stemming
mitochondrial
dysfunction,
leading
discusses
interconnections
oxidative
Conclusions:
Atherogenic
endothelial
cytokines
collectively
contribute
Potential
targets
are
focused
prevention
use
drugs
address
elevated
blood
lipid
levels.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(9), С. 4077 - 4077
Опубликована: Апрель 25, 2025
The
recent
introduction
of
the
term
metabolic-dysfunction-associated
steatotic
liver
disease
(MASLD)
has
highlighted
critical
role
metabolism
in
disease’s
pathophysiology.
This
innovative
nomenclature
signifies
a
shift
from
previous
designation
non-alcoholic
fatty
(NAFLD),
emphasizing
condition’s
progressive
nature.
Simultaneously,
MASLD
become
one
most
prevalent
diseases
worldwide,
highlighting
urgent
need
for
research
to
elucidate
its
etiology
and
develop
effective
treatment
strategies.
review
examines
delineates
revised
definition
MASLD,
exploring
epidemiology
pathological
changes
occurring
at
various
stages
disease.
Additionally,
it
identifies
metabolically
relevant
targets
within
provides
summary
latest
targeted
drugs
under
development,
including
those
clinical
some
preclinical
stages.
finishes
with
look
ahead
future
therapy
goal
summarizing
providing
fresh
ideas
insights.
BMC Endocrine Disorders,
Год журнала:
2024,
Номер
24(1)
Опубликована: Авг. 29, 2024
Follistatin-like
protein
1
(FSTL1)
has
been
identified
as
a
secreted
glycoprotein
that
plays
an
important
role
in
obesity.
However,
its
children
with
metabolic-associated
fatty
liver
disease
(MAFLD)
not
investigated.
This
study
aimed
at
characterizing
the
relationship
between
serum
FSTL1
concentration
and
MAFLD
Liver International,
Год журнала:
2024,
Номер
44(10), С. 2793 - 2806
Опубликована: Июль 31, 2024
Dysregulation
of
bile
acids
(BAs),
as
important
signalling
molecules
in
regulating
lipid
and
glucose
metabolism,
contributes
to
the
development
non-alcoholic
fatty
liver
disease
(NAFLD).
However,
static
BA
profiles
during
fasting
may
obscure
certain
pathogenetic
aspects.
In
this
study,
we
investigate
dynamic
alterations
BAs
response
an
oral
tolerance
test
(OGTT)
among
children
with
NAFLD.
Diabetes Metabolic Syndrome and Obesity,
Год журнала:
2024,
Номер
Volume 17, С. 4627 - 4639
Опубликована: Дек. 1, 2024
Background:
Metabolic-associated
steatotic
liver
disease
(MASLD)
is
a
novel
term
proposed
in
2023
to
replace
non-alcoholic
fatty
(NAFLD)
with
the
aim
of
better
reflecting
its
pathogenesis
and
clinical
manifestations.
Vibration-controlled
transient
elastography
(VCTE)
an
evidence-based,
non-invasive
imaging
device
used
evaluate
fat
deposition
fibrosis.
It
can
effectively
detect
infiltration
greater
than
5%,
which
much
higher
previous
ultrasound
detection
rate
(it
difficult
below
30%).
Nevertheless,
prevalence
characteristics
MASLD
children
diagnosed
based
on
these
updated
criteria
are
currently
not
well
established.
Methods:
Currently,
prospective
multi-center
population-based
cohort
study
being
conducted
Wuxi,
China,
spanning
from
2035,
involving
5600
four
primary
schools.
Throughout
study's
baseline
follow-up
periods,
yearly
physical
examinations,
laboratory
tests,
VCTE
assessments,
bioelectrical
impedance
analysis
measure
MASLD-related
biomarkers.
Additionally,
questionnaire
administered
inquire
about
dietary
habits.
criteria,
corresponding
assessed.
Results:
Recruitment
began
March
13,
2023.
To
date,
1475
participants
have
completed
examination
survey.
Discussion:
Our
investigated
influencing
factors
Chinese
school-age
adolescents.
By
collecting
analyzing
data
examinations
survey
questionnaires,
it
may
propose
new
avenues
for
guiding
treatment
early-stage
prevention
children.
Trial
Registration:
Clinical
Trials
Registry
(NO.
ChiCTR2400080508).
Keywords:
MASLD,
student,
incidence,
VCTE,
The Lancet Regional Health - Western Pacific,
Год журнала:
2024,
Номер
49, С. 101150 - 101150
Опубликована: Июль 26, 2024
The
prevalence
of
metabolic-associated
steatotic
liver
disease
(MASLD)
is
rising
precipitously
among
children,
particularly
in
regions
or
countries
burdened
with
high
obesity.
However,
identifying
those
at
risk
remains
a
significant
challenge,
as
the
majority
do
not
exhibit
distinct
symptoms
MASLD.
There
an
urgent
need
for
widely
accepted
non-invasive
predictor
to
facilitate
early
diagnosis
and
management
disease.
Our
study
aims
1)
evaluate
compare
existing
predictors
MASLD,
2)
develop
practical
screening
strategy
tailored
local
Alimentary Pharmacology & Therapeutics,
Год журнала:
2024,
Номер
60(7), С. 982 - 983
Опубликована: Авг. 30, 2024
LINKED
CONTENT
This
article
is
linked
to
Harrison
et
al
papers.
To
view
these
articles,
visit
https://doi.org/10.1111/apt.17734
and
https://doi.org/10.1111/apt.18022
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1461 - 1461
Опубликована: Ноя. 28, 2024
Low
molecular
weight
(LMW)
thiols,
particularly
glutathione,
play
pathogenic
roles
in
various
multiorgan
diseases.
The
liver
is
central
for
the
production
and
systemic
distribution
of
LMW
thiols;
thus,
it
susceptible
to
imbalance
redox
status
that
may
determine
increased
oxidative
stress
trigger
damage
observed
metabolic
dysfunction-associated
steatotic
disease
(MASLD)
models
humans.
Indeed,
thiols
at
cellular
extracellular
levels
be
associated
with
severity
MASLD.
Here,
we
present
a
systematic
literature
review
recent
studies
assessing
MASLD
vivo
vitro
human
subjects.
Based
on
PRISMA
2020
criteria,
search
was
conducted
using
PubMed
Scopus
by
applying
inclusion/exclusion
filters.
initial
returned
1012
documents,
from
which
165
eligible
were
selected,
further
described,
qualitatively
analysed.
Of
these
studies,
most
focused
animal
models,
while
minority
used
fluids.
analysis
revealed
heterogeneity
methods
sample
processing
measurement
thiol
levels,
hinder
cut-off
values
diagnostic
use.
Standardisation
measure
necessary
facilitate
future
studies.
