Advances in Engineered Phages for Disease Treatment
Small Methods,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
Abstract
Phage
therapy
presents
a
promising
solution
for
combating
multidrug‐resistant
(MDR)
bacterial
infections
and
other
bacteria‐related
diseases,
attributed
to
their
innate
ability
target
lyse
bacteria.
Recent
clinical
successes,
particularly
in
treating
MDR‐related
respiratory
post‐surgical
infections,
validated
the
therapeutic
potential
of
phage
therapy.
However,
complex
microenvironment
within
human
body
poses
significant
challenges
activity
efficacy
vivo.
To
overcome
these
barriers,
recent
advances
engineering
have
aimed
enhance
targeting
accuracy,
improve
stability
survivability,
explore
synergistic
combinations
with
modalities.
This
review
provides
comprehensive
overview
therapy,
emphasizing
application
engineered
phages
antibacterial
tumor
vaccine
development.
Furthermore,
highlights
current
future
trends
advancing
toward
broader
applications.
Язык: Английский
Healthcare-Associated Infections: The Role of Microbial and Environmental Factors in Infection Control—A Narrative Review
Infectious Diseases and Therapy,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Язык: Английский
Phage therapy: a promising approach for Staphylococcus aureus diabetic foot infections
Journal of Virology,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 14, 2025
ABSTRACT
Diabetic
foot
infections
(DFIs),
predominantly
caused
by
Staphylococcus
aureus
,
pose
a
significant
healthcare
challenge
with
severe
consequences,
including
amputation.
Phage
therapy,
which
utilizes
bacteriophages
to
specifically
target
bacterial
pathogens,
has
emerged
as
promising
alternative
conventional
antibiotic
treatments.
This
review
evaluates
the
efficacy
of
phage
therapy
complementary
treatment
for
DFIs
S.
synthesizing
evidence
from
preclinical
and
clinical
studies
while
addressing
limitations
challenges
associated
current
research.
The
analysis
highlights
results
diabetic
animal
models,
demonstrating
effective
load
reduction
improved
wound
healing.
Clinical
case
reports
series
further
underline
improvements
in
infection
management
ulcer
healing,
no
major
adverse
effects
reported.
Ongoing
trials
are
also
discussed,
offering
insights
into
study
parameters
evaluating
potential
safety
-related
DFIs.
While
collected
data
highlight
valuable
complement
traditional
treatments,
particularly
managing
antibiotic-resistant
infections,
research
is
essential
address
existing
limitations,
gaps
long-term
standardization.
With
continued
investigation,
holds
alleviate
burden
improve
patient
outcomes.
Язык: Английский
Current Clinical Laboratory Challenges to Widespread Adoption of Phage Therapy in the United States
Antibiotics,
Год журнала:
2025,
Номер
14(6), С. 553 - 553
Опубликована: Май 29, 2025
The
resurgence
of
phage
therapy
in
Western
societies
has
been
direct
response
to
recent
increases
antimicrobial
resistance
(AMR)
that
have
ravaged
many
societies.
While
as
a
concept
around
for
over
100
years,
it
largely
replaced
by
antibiotics
due
their
relative
ease
use
and
predictability
spectrum
activity.
Now
become
less
reliable
greater
antibiotic
microbiome
disruption,
once
again
viable
promising
alternative,
but
is
not
without
its
challenges.
Much
like
the
development
antibiotics,
with
deployment
therapeutics
there
will
be
simultaneous
need
diagnostics
clinical
laboratory.
This
review
provides
an
overview
current
challenges
widespread
adoption
focus
on
diagnostic
Current
barriers
include
lack
standard
methodology
quality
controls
susceptibility
testing
selection,
absence
phage-antibiotic
synergy
testing,
methods
assay
activity
biofilms.
Additionally,
are
number
lab-specific
administrative
regulatory
including
pharmacokinetic
(PK)
pharmacodynamic
(PD)
assays,
account
changes
phages
after
passaging,
guidance
what
required
agency
approvals
how
broad
approval
apply,
increased
lab
personnel
or
automation
work
large
libraries
against
bacteria
isolates.
Язык: Английский