Genome based characterization of Yersinia enterocolitica from different food matrices in Switzerland in 2024
Infection Genetics and Evolution,
Год журнала:
2025,
Номер
unknown, С. 105719 - 105719
Опубликована: Янв. 1, 2025
Язык: Английский
Source attribution of human Campylobacter infection: a multi-country model in the European Union
Frontiers in Microbiology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 5, 2025
Introduction
Infections
caused
by
Campylobacter
spp.
represent
a
severe
threat
to
public
health
worldwide.
National
action
plans
have
included
source
attribution
studies
as
way
quantify
the
contribution
of
specific
sources
and
understand
dynamic
transmission
foodborne
pathogens
like
Salmonella
.
Such
information
is
crucial
for
implementing
targeted
intervention.
The
aim
this
study
was
predict
human
campylobacteriosis
cases
across
multiple
countries
using
available
whole-genome
sequencing
(WGS)
data
explore
impact
availability
sample
size
distribution
in
multi-country
model.
Methods
We
constructed
machine-learning
model
k
-mer
frequency
patterns
input
per
source.
then
based
on
from
all
countries.
Results
different
sampling
strategies
were
compared
assess
unbalanced
datasets
prediction
cases.
results
showed
that
variety
sampled
quantity
samples
each
impacted
performance
Most
attributed
broilers
or
cattle
individual
models.
proportion
could
be
with
70%
probability
decreased
when
down-sampled
set
(535
vs.
273
2627
cases).
baseline
higher
sensitivity
model,
where
more
evenly
distributed.
non-domestic
but
varied
depending
strategy.
Both
models
most
domestic
country
(baseline:
248/273
cases,
91%;
down-sampled:
361/535
67%;).
Discussion
sizes
influence
accuracy
consequently
uncertainty
predicted
estimates.
estimates
high
number
tend
overestimated,
whereas
only
few
underestimated.
Reccomendations
future
include
balanced
improve
overall
utility
efforts.
Язык: Английский
Weak phospholipase-positive Listeria monocytogenes: a challenge for the diagnostic laboratory
Diagnostic Microbiology and Infectious Disease,
Год журнала:
2025,
Номер
112(3), С. 116802 - 116802
Опубликована: Март 14, 2025
Язык: Английский
Characteristics and comparative genome analysis of Yersinia enterocolitica and related species associated with human infections in Switzerland 2019–2023
Infection Genetics and Evolution,
Год журнала:
2024,
Номер
123, С. 105652 - 105652
Опубликована: Авг. 3, 2024
We
aimed
to
characterise
Yersinia
enterocolitica
from
human
clinical
specimens
in
Switzerland
using
epidemiological,
microbiological
and
whole-genome
sequencing
(WGS)
data.
Isolates
(n
=
149)
were
collected
between
January
2019
December
2023.
Epidemiological
data
was
noted
strains
characterized
by
biochemical
serological
typing,
antimicrobial
susceptibility
testing
(AST),
WGS-based
analysis.
Most
of
the
isolates
(86%)
stool
52%
male
patients.
The
patients'
median
age
28
years
(range
<
1–94
years).
Typing
assigned
bioserotype
4/O:3
(44%),
biotype
1A
(34%),
2/O:9
(21%),
3/O:3
(1%).
WGS
identified
Y.
147),
alsatica
1)
proxima
1).
Seven
multidrug
resistant
(MDR)
harboured
plasmid
pAB829
carrying
aph(3″)-Ib,
aph(6)-Id,
tet(Y)
1),
pAC120
aph(6)-Id
tet(A)
2),
or
a
12.6
kb
Tn2670-like
transposon
containing
catA1,
aadA12,
sul1,
qacEΔ1
4).
Virulence
factors
(VFs)
included
ail
99),
invB,
145),
ystA
ystB
48)
pYV-associated
VFs
93).
MLST
cgMLST
analysis
showed
that
BT
consisted
several
STs
highly
diverse,
whereas
all
ST12
clustered
closely,
mostly
belonged
ST18
but
more
diverse.
SNP
revealed
two
clonal
subpopulations
with
wide
spatio-temporal
distribution.
1A,
are
frequently
associated
yersiniosis
Switzerland.
subtyping
is
powerful
tool
explore
genetic
diversity
pathogenic
potential
isolates.
Язык: Английский
Five centuries of genome evolution and multi-host adaptation of Campylobacter jejuni in Brazil
Microbial Genomics,
Год журнала:
2024,
Номер
10(7)
Опубликована: Июль 19, 2024
Consumption
of
raw,
undercooked
or
contaminated
animal
food
products
is
a
frequent
cause
Язык: Английский