Antioxidant Hydrogels: Antioxidant Mechanisms, Design Strategies, and Applications in the Treatment of Oxidative Stress‐Related Diseases

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(11)

Опубликована: Янв. 2, 2024

Oxidative stress is a biochemical process that disrupts the redox balance due to an excess of oxidized substances within cell. closely associated with multitude diseases and health issues, including cancer, diabetes, cardiovascular diseases, neurodegenerative disorders, inflammatory conditions, aging. Therefore, developing antioxidant treatment strategies has emerged as pivotal area medical research. Hydrogels have garnered considerable attention their exceptional biocompatibility, adjustable physicochemical properties, capabilities for drug delivery. Numerous hydrogels been developed proven effective in alleviating oxidative stress. In pursuit more treatments stress-related there urgent need advanced fabrication multifunctional hydrogels. Consequently, authors' focus will be on possess reactive oxygen species nitrogen scavenging capabilities, role therapy evaluated. Herein, mechanisms design applications are discussed systematically order provide critical insights further advancements field.

Язык: Английский

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Nb2CTx MXene coating with inhibition of oxidative stress prepared by Marangoni effect for hemodialysis therapy

Chemical Engineering Journal, Год журнала: 2024, Номер 485, С. 150047 - 150047

Опубликована: Фев. 27, 2024

Язык: Английский

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Carboxymethyl chitosan hydrogel network constructed PES ultrafiltration membrane to separate bovine serum albumin from collagen

Separation and Purification Technology, Год журнала: 2025, Номер unknown, С. 132314 - 132314

Опубликована: Фев. 1, 2025

Язык: Английский

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Rational design of hemocompatible hydrogel microspheres towards pathogen-associated molecular patterns removal for Gram-positive bacteria-induced sepsis

Chemical Engineering Journal, Год журнала: 2024, Номер 489, С. 151461 - 151461

Опубликована: Апрель 18, 2024

Язык: Английский

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Metal–organic framework-based adsorbents for blood purification: progress, challenges, and prospects

Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(15), С. 3594 - 3613

Опубликована: Янв. 1, 2024

This review for the first time summarizes structure–function relationship between MOFs and toxin adsorption, as well biocompatibility practicality HD, HP, ECMO. It is anticipated that this will expand interest of researchers more impact in area.

Язык: Английский

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Simultaneous alleviating oxidative stress and scavenging uric acid via Janus polyethersulfone hemodialysis membrane loaded with urate oxidase-like nanoenzyme

Separation and Purification Technology, Год журнала: 2024, Номер 354, С. 128705 - 128705

Опубликована: Июль 5, 2024

Язык: Английский

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State‐of‐the‐Art Synthesis of Porous Polymer Materials and Their Several Fantastic Biomedical Applications: a Review

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

Porous polymers, including hydrogels, covalent organic frameworks (COFs), and hyper crosslinked polymers (HCPs), have become essential in biomedical research for their tunable pore architectures, large surface areas, functional versatility. This review provides a comprehensive overview of classification updated synthesis mechanisms, such as 3D printing, electrospinning, molecular imprinting. Their pivotal roles drug delivery, tissue engineering, wound healing, photodynamic/photothermal therapies, focusing on how size, distribution, architecture impact release, cellular interactions, therapeutic outcomes, are explored. Key challenges, biocompatibility, mechanical strength, controlled degradation, scalability, critically assessed alongside emerging strategies to enhance clinical potential. Finally, recent challenges future perspectives, emphasizing the broader applications porous addressed. work valuable insights advancing next-generation innovations through these materials.

Язык: Английский

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Preparation of antioxidant hemodialysis membranes by in situ growth of citric acid-terminated Prussian blue nanoenzymes

Journal of Membrane Science, Год журнала: 2025, Номер unknown, С. 123847 - 123847

Опубликована: Фев. 1, 2025

Язык: Английский

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Straightforward Approach Toward Thermo‐Sensitive Hydrogel Coating on Polyethersulfone Membranes with Controlled Drug Delivery for Significant Inhibition of Thrombocytopenia During Hemodialysis

Macromolecular Bioscience, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Abstract Thrombocytopenia is a potential complication associated with hemodialysis due to the unsatisfactory hemocompatibility of current dialysis membranes, which leads excessive platelet destruction, accelerates organ failure, and threatens patients’ life safety in severe cases. In clinical application hemodialysis, there are proportion patients suffer thrombocytopenia. For these patients, heparin combined tirofiban can be used during suppress occurrence thrombocytopenia, but medication requires intravenous injection continuous infusion. To optimize membrane composed polyethersulfone (PES) base temperature‐sensitive hydrogel coating poly ( N ‐acryloyl glycinamide) (PNAGA) designed, prepared that continuously release through temperature control reduce burden on significantly inhibit The resulting exhibits an encapsulation efficiency 36.2% (72.4 µg mL −1 ) for tirofiban, drug rates 54.83% at 37 °C 31.4% 4 after 1 h. Additionally, shows excellent hydrophilicity performance. It also effectively inhibits adhesion (reduced by 92.3%), activation 92.8%) aggregation, albumin adsorption 84.7%). summary, work provides new solution preparation membranes prevent has applications safer manufacturing sector.

Язык: Английский

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High-flux, antifouling, toxin-adsorptive and photothermally antibacterial borocarbonitrides nanosheets based mixed-matrix membrane for efficient hemodialysis

Journal of Membrane Science, Год журнала: 2025, Номер unknown, С. 124138 - 124138

Опубликована: Апрель 1, 2025

Язык: Английский

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