Rhodium Catalysts Based on Phenyl Substituted Cp Ligands for Indole Synthesis via Oxidative Coupling of Acetanilides and Alkynes DOI
Vladimir B. Kharitonov, Dmitry V. Muratov,

А. N. Rodionov

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(22), С. 4729 - 4736

Опубликована: Авг. 16, 2024

Abstract Rhodium‐catalyzed oxidative coupling of acetanilides and alkynes via C−H activation is the most powerful synthetic tool for producing indole motif from commercially available precursors. However, this reaction usually requires large catalyst loadings (5 mol% rhodium). In study, a 1,2‐diphenylcyclopentadienyl ligand‐based was developed that works well at 1 loading rhodium. DFT calculations step provided insight into its high catalytic activity. The efficiency also demonstrated in synthesis naturally occurring isocoumarins, such as polygonolide, tubakialactone B penicimarine F. protocols tolerate wide range functional groups, example, halide, nitro, hydroxy, alkoxy.

Язык: Английский

Rhodium Catalysts Based on Phenyl Substituted Cp Ligands for Indole Synthesis via Oxidative Coupling of Acetanilides and Alkynes DOI
Vladimir B. Kharitonov, Dmitry V. Muratov,

А. N. Rodionov

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(22), С. 4729 - 4736

Опубликована: Авг. 16, 2024

Abstract Rhodium‐catalyzed oxidative coupling of acetanilides and alkynes via C−H activation is the most powerful synthetic tool for producing indole motif from commercially available precursors. However, this reaction usually requires large catalyst loadings (5 mol% rhodium). In study, a 1,2‐diphenylcyclopentadienyl ligand‐based was developed that works well at 1 loading rhodium. DFT calculations step provided insight into its high catalytic activity. The efficiency also demonstrated in synthesis naturally occurring isocoumarins, such as polygonolide, tubakialactone B penicimarine F. protocols tolerate wide range functional groups, example, halide, nitro, hydroxy, alkoxy.

Язык: Английский

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