Nutrition Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 2, 2024
Abstract
Nutritional
status
disorders
have
the
most
significant
impact
on
development
of
cardiovascular
and
oncologic
diseases;
therefore,
interest
in
study
palm
oil
as
among
leading
components
nutrition
has
been
increasing.
The
data
examined
this
review
were
sourced
from
Scopus,
SCIE
(Web
Science),
PubMed
Central,
MEDLINE,
CAPlus/SciFinder,
Embase
databases;
experts
field;
bibliographies;
abstracts
analyses
past
15
years.
This
summarizes
recent
research
focusing
quantitative
qualitative
composition
modern
humans;
concepts
relationship
between
high-fat
diets
insulin
functioning
transport
metabolism
fatty
acids;
regarding
palmitic
acid
(16:0)
to
oleic
(18:1)
ratio;
effect
diet
based
consumption
risk
factors
lipid
lipoprotein
levels.
Several
studies
suggest
a
potential
vector
contributing
transmission
maternal,
high-fat-diet-induced,
addictive-like
behaviors
obesogenic
phenotypes
across
generations.
cholesterol
accumulation
lysosomes
that
may
lead
lysosome
dysfunction
inhibition
autophagy
process
is
analyzed,
progression
inflammatory
diseases,
atherosclerosis,
nonalcoholic
liver
inflammation,
obesity
with
associated
complications.
Data
are
discussed
differences
rodent
models
human
population
investigated
different
effects
component.
A
conclusion
reached
results
cannot
be
generalized
because
no
similar
observed.
Although
there
numerous
published
reports,
more
necessary
elucidate
complex
regulatory
mechanisms
digestive
processes,
great
profiles
rodents
humans,
which
makes
it
difficult
reproduce
pathology
many
diseases
caused
by
types
diet.
Nature Medicine,
Год журнала:
2024,
Номер
30(12), С. 3624 - 3633
Опубликована: Дек. 1, 2024
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
exhibits
considerable
variability
in
clinical
outcomes.
Identifying
specific
phenotypic
profiles
within
MASLD
is
essential
for
developing
targeted
therapeutic
strategies.
Here
we
investigated
the
heterogeneity
of
using
partitioning
around
medoids
clustering
based
on
six
simple
variables
a
cohort
1,389
individuals
living
with
obesity.
The
identified
clusters
were
applied
across
three
independent
cohorts
biopsy
(totaling
1,099
participants),
and
UK
Biobank
to
assess
incidence
chronic
disease,
cardiovascular
type
2
diabetes.
Results
unveiled
two
distinct
types
associated
steatohepatitis
histology
imaging.
first
cluster,
liver-specific,
was
genetically
linked
showed
rapid
progression
but
limited
risk
disease.
second
cardiometabolic,
primarily
dysglycemia
high
levels
triglycerides,
leading
similar
higher
Analyses
samples
from
831
available
transcriptomics
1,322
plasma
metabolomics
highlighted
that
these
exhibited
transcriptomic
metabolomic
signatures,
respectively.
In
conclusion,
data
provide
preliminary
evidence
existence
clinically
relevant
phenotypes
at
baseline,
each
underlying
biological
different
trajectories,
suggesting
need
tailored
Partitioning
multiple
patient
identifies
subtypes
metabolic
associations
hepatic
Journal of Gastroenterology and Hepatology,
Год журнала:
2024,
Номер
39(8), С. 1636 - 1647
Опубликована: Май 2, 2024
Abstract
Background
and
Aim
The
introduction
of
the
latest
nomenclature,
metabolic
associated
steatotic
liver
disease
(MASLD),
proposed
by
multi‐society
without
Asian
society
consensus
statement,
aims
to
redefine
diagnostic
criteria
for
fatty
(MAFLD).
However,
its
effect
on
epidemiology
in
Asia
remains
unclear.
Method
We
conducted
a
population‐based
cross‐sectional
survey
using
multistage
stratified
random
sampling
participants
from
Guangzhou,
representative
area
China
(ChiCTR2000033376).
Demographic,
socioeconomic,
lifestyle,
laboratory
data
were
collected.
Hepatic
steatosis
severity
fibrosis
assessed
FibroScan.
Results
A
total
7388
individuals
recruited,
proportion
which
meeting
definitions
nonalcoholic
(NAFLD),
MAFLD,
MASLD
2359
(31.9%),
2666
(36.1%),
2240
(30.3%),
respectively.
One
hundred
twenty
(1.6%)
patients
had
cryptogenic
SLD,
537
(7.3%)
diagnosed
with
MetALD.
did
not
significantly
differ
NAFLD
except
that
MAFLD
lower
males,
hypertension,
diabetes
less
likely
consume
tea
(
P
<
0.05).
Both
SLD
non‐MAFLD
exhibited
milder
hepatic
frequency
injury
than
NAFLD,
or
(all
An
increased
HOMA‐IR
(adjusted
OR:
1.33,
95%
CI:
1.10–2.03)
was
higher
risk
moderate‐to‐severe
patients,
while
consuming
more
cups
trend
=
0.015)
showed
inverse
associations.
Conclusion
Irrespective
terminology
used
is
highly
prevalent
Han
Chinese
population.
Differences
insulin
resistance
lifestyle
factors
are
redefinition
disparities.
Summary
Non‐alcoholic
fatty
liver
disease
(NAFLD)
is
a
disorder
characterized
by
excessive
accumulation
of
fat
in
the
that
can
progress
to
inflammation
(non‐alcoholic
steatohepatitis
[NASH]),
fibrosis,
and
cirrhosis.
Although
most
efforts
for
drug
development
are
focusing
on
treatment
latest
stages
NAFLD,
where
significant
fibrosis
NASH
present,
findings
from
studies
suggest
amount
may
be
an
important
independent
risk
factor
and/or
predictor
progression
NAFLD
metabolic
diseases.
In
this
review,
we
first
describe
current
tools
available
quantification
humans
then
present
clinical
pathophysiological
evidence
link
with
as
well
cardiometabolic
Finally,
discuss
pharmacological
non‐pharmacological
approaches
reduce
open
questions
have
addressed
future
studies.
JHEP Reports,
Год журнала:
2023,
Номер
6(2), С. 100974 - 100974
Опубликована: Ноя. 28, 2023
Background
&
AimsThe
mechanism
behind
the
progressive
pathological
alteration
in
MASLD/MASH-associated
HCC
is
poorly
understood.
In
present
study,
we
have
investigated
role
of
polyol
pathway
enzyme,
AKR1B1
metabolic
switching
associated
with
MASLD/MASH
and
progression
HCC.MethodsThe
expression
tissue
plasma
patients
MASLD/MASH,
HCC,
diabetes
mellitus
were
estimated.
The
vitro
was
assessed
through
media
conditioning,
lentiviral
transfection,
pharmacological
probes.
proteomic
metabolomic
approach
applied
for
in-depth
investigation
pathway.
Preclinically,
a
high
fructose
diet
(HFrD)
diethyl
nitrosamine
(DEN)
induced
mouse
model
developed
to
investigate
hyperglycemia-mediated
pathobiology
MASLD-HCC.ResultsA
significant
increase
observed
HCC-DM
samples
compared
normal
samples.
Mechanistically,
vitro,
assays
revealed
that
modulates
Warburg
effect,
mitochondrial
dynamics,
TCA
cycle,
lipogenesis
promote
MASLD
cancer
progression.
A
pathologically
increased
experimental
MASLD-HCC,
positively
correlated
blood
glucose
levels.
HFrD+DEN-treated
animals
also
exhibited
statistically
elevation
markers
carcinogenesis
markers.
However,
inhibition
EPS
or
NARI-29
has
inhibited
cellular
metabolism
vivo
models.ConclusionsPathological
hepatic
MASLD-associated
hepato-carcinogenesis.
Aldose
reductase
glycolytic
prevent
pre-cancerous
hepatocyte
formation.Impact
ImplicationsThe
research
work
vitalizes
as
druggable
target
MASH/MASLD
which
will
provide
base
developing
new
chemotherapeutic
agents.
Moreover,
study
implicates
use
levels
prognostic
marker
diagnostic
test
HCC.
Additionally,
major
observation
promotion
effect
Hepatology Communications,
Год журнала:
2023,
Номер
7(1), С. e0016 - e0016
Опубликована: Янв. 1, 2023
Background
and
Aims:
Phenotypic
heterogeneity
among
patients
with
NAFLD
is
poorly
understood.
We
aim
to
identify
clinically
important
phenotypes
within
assess
the
long-term
outcomes
different
phenotypes.
Methods:
analyzed
clinical
data
of
2311
participants
from
Third
National
Health
Nutrition
Examination
Survey
(NHANES
III)
their
linked
mortality
through
December
2019.
was
diagnosed
by
ultrasonographic
evidence
hepatic
steatosis
without
other
liver
diseases
excess
alcohol
use.
A
2-stage
cluster
analysis
applied
used
Cox
proportional
hazard
models
explore
all-cause
cause-specific
between
clusters.
Results:
identified
3
Cluster
1
characterized
young
female
better
metabolic
profiles
lower
prevalence
comorbidities;
2
obese
females
significant
insulin
resistance,
diabetes,
inflammation,
advanced
fibrosis
male
hypertension,
atherogenic
dyslipidemia,
kidney
damage.
In
a
median
follow-up
26
years,
989
(42.8%)
occurred.
presented
best
prognosis,
whereas
had
higher
risks
(Cluster
2—adjusted
HR:
1.48,
95%
CI:
1.16–1.90;
3—adjusted
1.29,
1.01–1.64)
cardiovascular
2.01,
1.18–3.44;
1.75,
1.03–2.97)
mortality.
Conclusions:
Three
phenotypically
distinct
meaningful
subgroups
have
been
characteristics
profiles.
This
study
reveals
substantial
disease
that
exists
underscores
need
for
granular
assessments
define
improve
practice.
