Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age

Nutrients, Год журнала: 2023, Номер 16(1), С. 63 - 63

Опубликована: Дек. 25, 2023

Sarcopenia is an age-related clinical complaint characterized by the progressive deterioration of skeletal muscle mass and strength over time. Type 2 diabetes (T2D) associated with faster more relevant impairment. Both conditions influence each other, leading to negative consequences on glycemic control, cardiovascular risk, general health status, risk falls, frailty, overall quality life, mortality. PubMed/Medline, Scopus, Web Science, Google Scholar were searched for research articles, scientific reports, observational studies, trials, narrative systematic reviews, meta-analyses review evidence pathophysiology di-abetes-induced sarcopenia, its relevance in terms glucose control diabetes-related outcomes, diagnostic therapeutic challenges. The comprehensively addresses key elements definition criteria pathophysiological correlation be-tween T2D, related a critical role antihyperglycemic treatment health, perspectives specific targeting myokine signaling pathways involved regulation metabolism trophism. Prompt diagnosis adequate management, including lifestyle inter-vention, diet programs, micronutrient supplementation, physical exercise, pharmaco-logical treatment, are needed prevent or delay T2D.

Язык: Английский

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The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: Implications for emerging pharmacotherapies aiming at fat reduction and lean mass preservation

Metabolism, Год журнала: 2024, Номер unknown, С. 156057 - 156057

Опубликована: Окт. 1, 2024

Язык: Английский

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Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease

Frontiers in Endocrinology, Год журнала: 2025, Номер 15

Опубликована: Янв. 9, 2025

Non-alcoholic fatty liver disease (NAFLD) is a multisystem metabolic disorder, marked by abnormal lipid accumulation and intricate inter-organ interactions, which contribute to systemic imbalances. NAFLD may progress through several stages, including simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), cirrhosis, potentially cancer. This closely associated with disorders driven overnutrition, key pathological processes dysregulation, impaired autophagy, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, local inflammation. While hepatic metabolism in well-documented, further research into communication mechanisms crucial for deeper understanding of progression. review delves intrahepatic networks tissue-specific signaling mediators involved pathogenesis, emphasizing their impact on distal organs.

Язык: Английский

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Milestones in the journey towards addressing obesity; Past trials and triumphs, recent breakthroughs, and an exciting future in the era of emerging effective medical therapies and integration of effective medical therapies with metabolic surgery

Metabolism, Год журнала: 2023, Номер 148, С. 155689 - 155689

Опубликована: Сен. 7, 2023

Язык: Английский

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Circulating hormones in biopsy-proven steatotic liver disease and steatohepatitis: A Multicenter Observational Study

Metabolism, Год журнала: 2023, Номер 148, С. 155694 - 155694

Опубликована: Сен. 25, 2023

Язык: Английский

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Weight-adjusted waist index is positively and linearly associated with all-cause and cardiovascular mortality in metabolic dysfunction-associated steatotic liver disease: findings from NHANES 1999-2018

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Сен. 30, 2024

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic disease. Body mass index (BMI) used obesity but has important limitations. The weight-adjusted waist (WWI) a novel metric and accurately reflects body composition. We explored association of WWI with all-cause cardiovascular (CVD) mortality in MASLD. Methods Adult participants MASLD were included from NHANES 1999-2018. was calculated by dividing circumference (WC) square root weight. diagnosed presence hepatic steatosis at least one cardiometabolic risk factor absence other causes steatosis. A fatty ≥60 suggested Mortality data obtained prospectively linking to National Death Index. Multivariate Cox proportional hazards regression analyses explore these associations multiple adjustment models constructed including crude, partial, fully adjusted models. Results After adjusting for all covariates BMI, remained positively linearly associated CVD (hazard ratios [HR] 1.247 1.218, respectively). Higher significantly increased (both p trend <0.05). There an “obesity paradox” between BMI MASLD, lower those overweight/obesity compared normal (HR 0.625 0.596, respectively, = 0.024), no mortality. Interaction indicated that influenced several demographic variables status. Time-dependent receiver operating characteristic curves predictive value higher than WC, waist-to-height ratio across follow-up durations. Conclusions whereas did not reflect risk. provided optimal traditional indicators. These findings emphasize potential use as indicator assessment, stratification, prevention

Язык: Английский

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Advances in body composition and gender differences in susceptibility to frailty syndrome: Role of osteosarcopenic obesity

Metabolism, Год журнала: 2024, Номер 161, С. 156052 - 156052

Опубликована: Окт. 28, 2024

Язык: Английский

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Causal relationships of circulating Amino acids with Sarcopenia-Related Traits: A bidirectional Mendelian randomization study

Clinical Nutrition, Год журнала: 2025, Номер 47, С. 258 - 264

Опубликована: Фев. 28, 2025

Язык: Английский

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The Role of Exercise in Steatotic Liver Diseases: An Updated Perspective

Liver International, Год журнала: 2024, Номер 45(1)

Опубликована: Дек. 25, 2024

The increasing prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty (NAFLD), parallels the rise in sedentary lifestyles. MASLD is most common form (SLD), which represents umbrella beneath vast majority chronic diseases fall, including alcohol-related and their overlap. These conditions are leading contributors to disease, significantly impacting global morbidity mortality. Despite emergence new pharmacotherapies, exercise foundation treatment.

Язык: Английский

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The combined impact of BMI and ABSI on all-cause mortality among American adults with diabetes

Diabetology & Metabolic Syndrome, Год журнала: 2025, Номер 17(1)

Опубликована: Фев. 7, 2025

Previous studies have emphasized the independent effects of anthropometric indices-including body mass index (BMI), A Body Shape Index (ABSI), waist-to-height ratio (WHtR), roundness (BRI), and Conicity Index-on mortality. However, their combined impact, especially in diabetic populations with distinct obesity patterns, has been less frequently explored. This study investigates both these indices on mortality Americans compares individual diagnostic value. nationally representative cohort was conducted using NHANES data (2005-2018), including 6,572 adults. Weighted Cox proportional hazards models restricted cubic splines were applied to evaluate associations (BMI, ABSI, WHtR, BRI, Index) all-cause The weighted receiver operating characteristic (ROC) curve used assess value combinations predicting Among all indices, ABSI exhibited strongest association mortality, outperforming other measures such as BMI, Index. clear linear relationship identified, higher tertiles consistently linked an increased risk Notably, within each BMI tertile, effectively differentiated risk, particularly highest tertile. Furthermore, demonstrated predictive performance among metrics (weighted AUC = 0.653) showed further improvement when 0.669). collectively provide a comprehensive evaluation populations, capturing synergistic general central obesity. These findings highlight importance integrating into assessments identify high-risk individuals guide targeted interventions for reducing

Язык: Английский

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