Association of volatile organic compound exposure with metabolic syndrome and its components: a nationwide cross-sectional study
BMC Public Health,
Год журнала:
2024,
Номер
24(1)
Опубликована: Март 2, 2024
Abstract
Background
Metabolic
syndrome
(MetS)
is
a
health
issue
consisting
of
multiple
metabolic
abnormalities.
The
impact
exposure
to
volatile
organic
compounds
(VOCs)
on
MetS
and
its
components
remains
uncertain.
This
study
aimed
assess
the
associations
individual
urinary
metabolites
VOC
(mVOCs)
mVOC
mixtures
with
among
general
adult
population
in
United
States.
Methods
A
total
5345
participants
eligible
data
were
filtered
from
2011–2020
cycles
National
Health
Nutrition
Examination
Survey.
Multivariate
logistic
regression
models
applied
mVOCs
components.
least
absolute
shrinkage
selection
operator
(LASSO)
constructed
identify
more
relevant
mVOCs.
weight
quantile
sum
model
was
further
explore
links
between
co-exposure
Results
results
indicated
positive
MetS,
including
CEMA,
DHBMA,
HMPMA.
CEMA
found
be
positively
correlated
all
MetS.
HMPMA
associated
elevated
triglyceride
(TG),
reduced
high-density
lipoprotein,
fasting
blood
glucose
(FBG)
impairment;
3HPMA
an
risk
high
TG
FBG
DHBMA
had
pressure.
LASSO-selected
increased
TG,
pressure,
impairment.
Conclusion
Positive
certain
observed
by
utilizing
statistical
large-scale
national
data.
These
findings
may
serve
as
theoretical
basis
for
future
experimental
mechanistic
studies
have
important
implications
public
health.
Язык: Английский
Multifaceted roles of mitochondria in asthma
Cell Biology and Toxicology,
Год журнала:
2024,
Номер
40(1)
Опубликована: Окт. 9, 2024
Mitochondria
are
essential
organelles
within
cells,
playing
various
roles
in
numerous
cellular
processes,
including
differentiation,
growth,
apoptosis,
energy
conversion,
metabolism,
and
immunity.
The
phenotypic
variation
of
mitochondria
is
specific
to
different
tissues
cell
types,
resulting
significant
differences
their
function,
morphology,
molecular
characteristics.
Asthma
a
chronic,
complex,
heterogeneous
airway
disease
influenced
by
external
factors
such
as
environmental
pollutants
allergen
exposure,
well
internal
at
the
tissue,
cellular,
genetic
levels,
lung
structural
immune
granulocytes,
mast
cells.
Therefore,
comprehensive
understanding
responses
stimuli
changes
crucial
for
elucidating
pathogenesis
asthma.
Previous
research
on
mitochondrial-targeted
therapy
asthma
has
primarily
focused
antioxidants.
Consequently,
it
necessary
summarize
multifaceted
discover
additional
strategies
targeting
this
context.
In
review,
our
goal
describe
mitochondrial
function
response
exposure
across
types
other
relevant
context
asthma,
utilizing
new
terminology
framework
that
encompasses
cell-dependent
characteristics,
features,
activity,
behavior.
Язык: Английский