Apolipoprotein CIII correlates with lipoproteins in the fed state and is not regulated by leptin administration in states of hypoleptinemia induced by acute or chronic energy deficiency: Results from two randomised controlled trials

Diabetes Obesity and Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Abstract Background Medications targeting the leptin and Apolipoprotein CIII (APOC3) pathways are currently under development for treatment of hypertriglyceridaemia. Given that both implicated in triglyceride regulation, it is unknown whether they function independently or interact physiological conditions acute long‐term energy deficiency. Methods APOC3 levels their association with circulating lipids lipoproteins were evaluated context two randomised controlled studies. In Study‐1, 15 healthy individuals examined three distinct conditions, each lasting 72 h: isocaloric feeding, fasting placebo administration administered at replacement doses. Study‐2, 20 females hypoleptinemia due to relative deficiency sport (REDs) a minimum 6 months treated either 36 weeks. Results remained stable across all arms unaffected by administration. fed state, presented positive correlations various VLDL, IDL, LDL HDL sizes, free fatty acids (FFA), most which not replicated fasting. During complete deprivation, was correlated molecules, glutamine FFA, whereas its positively associated only FFA treatment. lower group, but this leptin‐dependent effect. A correlation between observed group. Conclusions These results contribute towards our better understanding intricate nature lipid regulation deficiency, suggesting medications act through different metabolic thus may have independent effects from other regulating triglycerides.

Язык: Английский

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Exploring How Adipose Tissue, Obesity, and Gender Influence the Immune Response to Vaccines: A Comprehensive Narrative Review

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 862 - 862

Опубликована: Янв. 20, 2025

Vaccines represent an essential tool for the prevention of infectious diseases. Upon administration, a complex interaction occurs between vaccine formulation and recipient’s immune system, ultimately resulting in protection against disease. Significant variability exists individual population responses to vaccination, these differences remain focus ongoing research. Notably, well-documented factors, such as age, gender, genetic predisposition, influence responses. In contrast, effects overweight obesity have not been thoroughly investigated. The evidence indicates that high body mass index (BMI) constitutes significant risk factor infections general, with adipose tissue playing crucial role modulating response. Furthermore, suboptimal levels seroconversion observed among individuals obesity. This review provides plausible examination immunity conferred by various vaccines status, offering comprehensive analysis mechanisms enhance vaccination efficiency.

Язык: Английский

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Three-protein signature is associated with baseline and persistently elevated or recurrent depressive symptoms in individuals with recent-onset diabetes

BMJ Open Diabetes Research & Care, Год журнала: 2025, Номер 13(1), С. e004396 - e004396

Опубликована: Янв. 1, 2025

Depression is associated with diabetes, but the underlying causes remain unclear. To better understand depression in this study investigated associations between 135 inflammatory and neurological protein biomarkers depressive symptoms individuals diabetes.This cross-sectional included 430 adults a known diabetes duration <1 year from German Diabetes Study (GDS), whom were measured serum evaluated at baseline annually over 5 years using Center for Epidemiological Studies Scale (CES-D). Based on information follow-up visits (n=305, ≥3 time points), we subdivided sample into persistent or recurrent transient never symptoms. We assessed of each biomarker CES-D score (continuous) persistent/recurrent multiple linear logistic regression models, respectively.After adjustment covariates, identified three-protein signature CUB domain-containing 1 (CDCP1) NAD-dependent deacetylase sirtuin-2 (SIRT2) positively (β 1.24 (95% CI 0.19 to 2.29); β 0.89 0.06 1.72)), respectively) (OR 1.58 1.08 2.31); OR 1.32 1.03 1.71), respectively), whereas leptin receptor (LEPR) was inversely -0.99 -1.87 -0.11)) 0.70 0.49 0.99)). However, results not significant after testing.In conclusion, may provide insights mechanisms might open new therapeutic avenues.The trial registration number NCT01055093.

Язык: Английский

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Intermittent fasting and neurodegenerative diseases: Molecular mechanisms and therapeutic potential

Metabolism, Год журнала: 2024, Номер 164, С. 156104 - 156104

Опубликована: Дек. 12, 2024

Язык: Английский

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