Bacteriophages from human skin infecting coagulase-negative Staphylococcus: diversity, novelty and host resistance

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 8, 2024

The human skin microbiome comprises diverse populations that differ temporally between body sites and individuals. virome is a less studied component of the study bacteriophages required to increase knowledge modulation stability bacterial communities. Staphylococcus species are among most abundant colonisers associated with both health disease yet infecting on well studied. Here, we report isolation genome sequencing 40 from swabs infect coagulase-negative (CoNS) species, which extends our phage diversity. Six genetic clusters phages were identified two representing novel phages, one characterise name Alsa phage. We have greater ability S. hominis was otherwise infected than other CoNS by isolated indicating an undescribed barrier infection could be in part due numerous restriction-modification systems. extended diversity here enables further research define their contribution mechanisms limit infection.

Язык: Английский

Intraspecies warfare restricts strain coexistence in human skin microbiomes

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 7, 2024

Determining why only a fraction of encountered or applied bacterial strains engraft in given person's microbiome is crucial for understanding and engineering these communities

Язык: Английский