bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Авг. 8, 2024
Enteric pathogens engage in complex interactions with the host and resident microbiota to establish gut colonization. Although mechanistic between enteric bacterial commensals have been extensively studied, whether how commensal fungi affect pathogenesis of infections remains largely unknown. Here we show that colonization common human fungus
Язык: Английский
The Journal of Experimental Medicine, Год журнала: 2025, Номер 222(6)
Опубликована: Апрель 15, 2025
Fungi increasingly threaten health globally. Mycoses range from life-threatening, often iatrogenic conditions, to enigmatic syndromes occurring without apparent immunosuppression. Despite some recent advances in antifungal drug development, complementary therapeutic strategies are essential for addressing these opportunistic pathogens. One promising avenue is leveraging host immunity combat fungal infections; this necessitates deeper understanding of the molecular immunology human susceptibility differentiate beneficial versus harmful immunopathological responses. Investigating models diseases natural settings, particularly through genetic immunodeficiencies and ethnographic-specific vulnerabilities, reveals crucial immune pathways fighting various yeasts molds. This review highlights diversity intrinsic across individuals populations, genetic- autoantibody-mediated processes, complementing previous principles learned animal studies contexts. Improved will facilitate development host-directed immunotherapies targeted public interventions, paving way precision medicine disease management.
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Окт. 25, 2024
Aspergillus fumigatus is the most common cause of invasive aspergillosis (IA), a devastating infection in immunocompromised patients. Plasmacytoid dendritic cells (pDCs) regulate host defense against IA by enhancing neutrophil antifungal properties lung. Here, we define pDC activation trajectory during A. and molecular events that underlie protective - crosstalk. Fungus-induced begins after bone marrow egress results pDC-dependent regulation lung type I III IFN levels. These pDC-derived products act on receptor-expressing neutrophils control fungicidal activity reactive oxygen species production via STAT1 signaling cell-intrinsic manner. Mechanistically, regulates transcription expression Cybb, which encodes one five NADPH oxidase subunits. Thus, pDCs neutrophil-dependent immunity inhaled molds controlling local subunit required for assembly
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Авг. 8, 2024
Enteric pathogens engage in complex interactions with the host and resident microbiota to establish gut colonization. Although mechanistic between enteric bacterial commensals have been extensively studied, whether how commensal fungi affect pathogenesis of infections remains largely unknown. Here we show that colonization common human fungus
Язык: Английский
Процитировано
0