UV Radiation Triggers Mycosporine-Glutaminol-Glucoside Biosynthesis in Naganishia friedmannii FBU002, a non-pathogenic yeast DOI
Gabriel Martins-Silva, Renan Santini Barbosa, Ronaldo Silva Santos

и другие.

Journal of Applied Microbiology, Год журнала: 2025, Номер 136(3)

Опубликована: Фев. 28, 2025

Ultraviolet radiation (UVR) interferes with aspects of life on Earth. It is necessary for the synthesis important molecules, as vitamin D, but it harmful to organisms leading photoaging and skin cancer. Artificial sunscreens prevent these effects, may be carcinogenic neurotoxic; also they accumulate in aquatic ecosystem, harming environment coral bleaching. Most artificial commercialized are fossil fuel derived produced by petrochemical industry. As society turns bioeconomy, substituted sustainable ones. Algae, cyanobacteria, fungi produce mycosporines mycosporine-like aminoacids, which absorb UV dissipate heat. They a natural source sunscreen low or no toxicity can biotechnological means; therefore, aim this study search mycosporine biosynthesis yeast from an extreme environment. Chromatographic spectroscopic data analyses demonstrated first time isolate Naganishia friedmannii, collected site high UVR incidence, able mycosporine-glutaminol-glucoside (MGG) its likely diastereoisomer, when exposed photosynthetically active (PAR)-UVR light. A biosynthetic gene cluster was identified N. friedmannii genome shown induced response real-time polimerase chain reaction (RT-PCR). Phenotypic characterization suggests non-pathogenic that tolerates UVC (UltraViolet C) other stresses. These features make suitable applications, adding value additive economically viable, environmentally friendly sunscreens.

Язык: Английский

UV Radiation Triggers Mycosporine-Glutaminol-Glucoside Biosynthesis in Naganishia friedmannii FBU002, a non-pathogenic yeast DOI
Gabriel Martins-Silva, Renan Santini Barbosa, Ronaldo Silva Santos

и другие.

Journal of Applied Microbiology, Год журнала: 2025, Номер 136(3)

Опубликована: Фев. 28, 2025

Ultraviolet radiation (UVR) interferes with aspects of life on Earth. It is necessary for the synthesis important molecules, as vitamin D, but it harmful to organisms leading photoaging and skin cancer. Artificial sunscreens prevent these effects, may be carcinogenic neurotoxic; also they accumulate in aquatic ecosystem, harming environment coral bleaching. Most artificial commercialized are fossil fuel derived produced by petrochemical industry. As society turns bioeconomy, substituted sustainable ones. Algae, cyanobacteria, fungi produce mycosporines mycosporine-like aminoacids, which absorb UV dissipate heat. They a natural source sunscreen low or no toxicity can biotechnological means; therefore, aim this study search mycosporine biosynthesis yeast from an extreme environment. Chromatographic spectroscopic data analyses demonstrated first time isolate Naganishia friedmannii, collected site high UVR incidence, able mycosporine-glutaminol-glucoside (MGG) its likely diastereoisomer, when exposed photosynthetically active (PAR)-UVR light. A biosynthetic gene cluster was identified N. friedmannii genome shown induced response real-time polimerase chain reaction (RT-PCR). Phenotypic characterization suggests non-pathogenic that tolerates UVC (UltraViolet C) other stresses. These features make suitable applications, adding value additive economically viable, environmentally friendly sunscreens.

Язык: Английский

Процитировано

0