Advances in Transdermal Drug Delivery: The Development of Microneedle Technology for Improved Therapeutic Outcomes DOI Creative Commons

Shivshankar M. Nagrik,

Vaishnavi S. Akhare,

M. W. Bhade

и другие.

Journal for Research in Applied Sciences and Biotechnology, Год журнала: 2024, Номер 3(5), С. 200 - 210

Опубликована: Ноя. 14, 2024

Transdermal Drug Delivery Systems (TDDS) represent a significant advancement in therapeutic administration by allowing drugs to bypass the gastrointestinal system and first-pass hepatic metabolism, enhancing patient compliance, enabling sustained drug release. However, traditional TDDS face limitations, including resistance from skin's natural barrier limited efficacy delivering large or hydrophilic molecules. Microneedle (MN) technology offers breakthrough solution, using minimally invasive micron-sized needles stratum corneum, facilitating efficient delivery without pain discomfort. This review explores evolution recent advancements microneedle technology, highlighting its role overcoming limitations of conventional TDDS. Microneedles have been shown enhance bioavailability, reduce side effects, expand range deliverable therapeutics, vaccines, insulin, genetic materials. The development bioinspired 4D microneedles further extends their application diagnostics cosmetic treatments, positioning MNs as versatile tool modern medicine. Key sections focus on types microneedles—solid, coated, dissolving, hollow, hydrogel-forming—and respective fabrication methods, materials, mechanisms. also discusses challenges related scaling up production, ensuring consistent quality, regulatory hurdles achieving clinical approval. Future directions include integration with nanotechnology, combination therapies, sustainable design, particularly developing regions where biodegradable materials may address environmental disposal concerns. potential for revolutionize transdermal delivery, diagnostics, monitoring is significant, ongoing research paving way multifunctional applications that can reshape care treatment modalities.

Язык: Английский

Smart Microneedles in Biomedical Engineering: Harnessing Stimuli‐Responsive Polymers for Novel Applications DOI
Farangis Shahi,

Hana Afshar,

Elmuez A. Dawi

и другие.

Polymers for Advanced Technologies, Год журнала: 2024, Номер 35(12)

Опубликована: Дек. 1, 2024

ABSTRACT This review aims to provide a comprehensive analysis of recent advancements in smart microneedles (MNs) within the biomedical field, focusing on integration stimuli‐responsive polymers for enhanced therapeutic and diagnostic applications. Conventional drug delivery methods are known face limitations precision, safety, patient compliance, which can be addressed by innovative features MNs. Through use various polymers, these MNs have been designed react environmental or physiological cues, allowing on‐demand release, biomarker sensing, localized interventions. Fundamental materials used fabrication MNs, including metals, composite hydrogels, reviewed, different categories stimuli‐responsiveness, such as photo, electro, thermal, mechanical, biochemical, explored. Application‐specific designs areas delivery, cancer therapy, diabetes management, skin disease treatments also examined. this discussion, it is highlighted that poised play significant role advancing personalized noninvasive medical treatments.

Язык: Английский

Процитировано

6
Modelling receptor-mediated endocytosis in hollow microneedle-based verapamil delivery through viscoelastic skin DOI

Tanmoy Bhuimali,

Sarifuddin Sarifuddin,

Prashanta Kumar Mandal

и другие.

Computer Methods in Biomechanics & Biomedical Engineering, Год журнала: 2025, Номер unknown, С. 1 - 19

Опубликована: Март 20, 2025

Drug delivered from the microneedle (MN) tip diffuses across viscoelastic skin before entering blood compartment and being absorbed. Reversible uptake kinetics between tissue compartments, reversible specific saturable binding with its receptors, endocytosis are given due attention. Simulations predict that, unlike thinning, viscoelasticity a higher Young's modulus value, as in an older person, inhibit verapamil diffusion within skin, metabolism stabilises concentrations compartments. Simultaneously, irreversible improve drug compartment, facilitating receptor-mediated endocytosis. The results also that internalised increases time at slower internalisation rates; however, rates, it attains peak value gradually diminishing. Furthermore, rate of lysosomal degradation escalates, concentration diminishes shifts upward. A comprehensive sensitivity analysis has been performed because uncertainty about several crucial parameters. Our findings align well existing literature.

Язык: Английский

Процитировано

0
Advances in Transdermal Drug Delivery: The Development of Microneedle Technology for Improved Therapeutic Outcomes DOI Creative Commons

Shivshankar M. Nagrik,

Vaishnavi S. Akhare,

M. W. Bhade

и другие.

Journal for Research in Applied Sciences and Biotechnology, Год журнала: 2024, Номер 3(5), С. 200 - 210

Опубликована: Ноя. 14, 2024

Transdermal Drug Delivery Systems (TDDS) represent a significant advancement in therapeutic administration by allowing drugs to bypass the gastrointestinal system and first-pass hepatic metabolism, enhancing patient compliance, enabling sustained drug release. However, traditional TDDS face limitations, including resistance from skin's natural barrier limited efficacy delivering large or hydrophilic molecules. Microneedle (MN) technology offers breakthrough solution, using minimally invasive micron-sized needles stratum corneum, facilitating efficient delivery without pain discomfort. This review explores evolution recent advancements microneedle technology, highlighting its role overcoming limitations of conventional TDDS. Microneedles have been shown enhance bioavailability, reduce side effects, expand range deliverable therapeutics, vaccines, insulin, genetic materials. The development bioinspired 4D microneedles further extends their application diagnostics cosmetic treatments, positioning MNs as versatile tool modern medicine. Key sections focus on types microneedles—solid, coated, dissolving, hollow, hydrogel-forming—and respective fabrication methods, materials, mechanisms. also discusses challenges related scaling up production, ensuring consistent quality, regulatory hurdles achieving clinical approval. Future directions include integration with nanotechnology, combination therapies, sustainable design, particularly developing regions where biodegradable materials may address environmental disposal concerns. potential for revolutionize transdermal delivery, diagnostics, monitoring is significant, ongoing research paving way multifunctional applications that can reshape care treatment modalities.

Язык: Английский

Процитировано

0