Human Endogenous Retroviruses as Novel Therapeutic Targets in Neurodegenerative Disorders DOI Creative Commons
Elena Rita Simula, Seyedesomaye Jasemi, Davide Cossu

и другие.

Vaccines, Год журнала: 2025, Номер 13(4), С. 415 - 415

Опубликована: Апрель 15, 2025

Human Endogenous Retroviruses comprise approximately 8% of the human genome, serving as fragments ancient retroviral infections. Although they are generally maintained in a silenced state by robust epigenetic mechanisms, specific HERV groups, particularly HERV-W and HERV-K, can become derepressed under pathological conditions, thereby contributing to initiation progression neuroinflammatory neurodegenerative processes. Preclinical studies clinical trials, such those investigating monoclonal antibodies, indicate that directly targeting these elements may offer novel therapeutic strategy. In this review, we provide an overview HERVs′ biology, examine their role diseases amyotrophic lateral sclerosis, multiple Alzheimer′s disease, Parkinson′s explore prospects, highlighting both challenges potential future research directions needed translate approaches into interventions.

Язык: Английский

Human Endogenous Retroviruses as Novel Therapeutic Targets in Neurodegenerative Disorders DOI Creative Commons
Elena Rita Simula, Seyedesomaye Jasemi, Davide Cossu

и другие.

Vaccines, Год журнала: 2025, Номер 13(4), С. 415 - 415

Опубликована: Апрель 15, 2025

Human Endogenous Retroviruses comprise approximately 8% of the human genome, serving as fragments ancient retroviral infections. Although they are generally maintained in a silenced state by robust epigenetic mechanisms, specific HERV groups, particularly HERV-W and HERV-K, can become derepressed under pathological conditions, thereby contributing to initiation progression neuroinflammatory neurodegenerative processes. Preclinical studies clinical trials, such those investigating monoclonal antibodies, indicate that directly targeting these elements may offer novel therapeutic strategy. In this review, we provide an overview HERVs′ biology, examine their role diseases amyotrophic lateral sclerosis, multiple Alzheimer′s disease, Parkinson′s explore prospects, highlighting both challenges potential future research directions needed translate approaches into interventions.

Язык: Английский

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