Outbreak of recombinant lumpy skin disease virus in yaks: high mortality and systemic pathogenesis in Qinghai-Tibet Plateau yak herds DOI Creative Commons

Jianwu Hu,

Yan Li, Xiaohu Zhang

и другие.

Frontiers in Veterinary Science, Год журнала: 2025, Номер 12

Опубликована: Май 21, 2025

The emergence of recombinant Lumpy Skin Disease Virus (LSDV) strains in Asia has led to outbreaks marked by severe skin nodules, high transmissibility, and transboundary spread, resulting significant economic losses cattle industries China neighboring countries. Qinghai-Tibet Plateau, historically a natural barrier against viral incursions, recently experienced increasing LSDV cases yaks (Bos grunniens). Current study elucidates the threat posed through clinical, pathological, molecular analyses. Field observations revealed infected exhibited fever, dyspnea, cutaneous pox lesions, lymphadenopathy, mucosal lesions. Viral DNA detection showed 100% positivity samples (6/6), 53.33% (8/15) nasal swabs, 33.33% (5/15) anal with an overall mortality rate 46.67% (7/15). Necropsy identified respiratory digestive system including tracheal congestion, pulmonary hemorrhagic plaques, ruminal serosal masses. Histopathology demonstrated dermal vasculitis, lymphocytic infiltration, inclusion bodies. Immunohistochemistry localized antigens hair follicle epithelia macrophages. Phylogenetic analysis positioned yak-derived strain (LSDV/China/GS/Yak) within Cluster 1.2 subclade homology circulating East/Southeast but differing from non-recombinant Indian strains. results emphasize increased pathogenicity plateau convey critical need for region-specific control strategies.

Язык: Английский

A poxvirus ankyrin protein LSDV012 inhibits IFIT1 in a host-species-specific manner by compromising its RNA binding ability DOI Creative Commons
Shijie Xie, Yongxiang Fang, Zhiyi Liao

и другие.

PLoS Pathogens, Год журнала: 2025, Номер 21(3), С. e1012994 - e1012994

Опубликована: Март 17, 2025

Poxviruses are large DNA viruses with an arsenal of immune-modulatory genes, many which remain uncharacterized. Proteins ankyrin repeats distinct features poxviruses, although the biological functions proteins not fully understood. Lumpy skin disease virus (LSDV) encodes five repeats. Here, we reveal role LSDV012, protein, in conferring resistance to type I interferon (IFN) cells. Deletion LSDV012 from LSDV significantly impacted viral replication presence IFN, highlighting importance antagonizing IFN responses. Further investigation revealed that interacted interferon-induced tetratricopeptide (IFITs), particularly IFIT1, altering its subcellular localization, interacting C-terminus and inhibiting RNA-binding ability without inducing degradation. Phylogenetic analysis demonstrated orthologs conserved capripoxviruses cervidpoxviruses , exhibit host species-specific interactions IFIT1. Notably, was able rescue degradation IFIT1 mediated by VACV C9. These findings provide novel insights into strategies employed subvert antiviral defenses underscore evolutionary adaptations poxvirus immune evasion.

Язык: Английский

Процитировано

0
Whole Genome Sequencing of Lumpy Skin Disease Virus from 2021–2023 in Eastern Eurasia Reveals No More Recombination Signals in the Circulating Pool of Strains DOI Creative Commons
Alexander Sprygin, Alena Krotova, Jun Ma

и другие.

Viruses, Год журнала: 2025, Номер 17(4), С. 468 - 468

Опубликована: Март 25, 2025

Having spanned thousands of kilometers from Africa through Europe, the Middle East, Central Asia to south eastern part Eurasia in recent decade, lumpy skin disease virus has now become entrenched China, Thailand, Vietnam, and South Korea. In light discovered findings on recombination, cluster 2.5 lineage strains are dominant continue spread throughout Southeast Asia. To gain a better picture phylogenetic landscape field, whole genome sequencing 11 LSDV isolates Russia Mongolia collected 2021 2023 been attempted see dynamics recombination signals, as was shown for circulating 2017–2019 Kazakhstan. Deep performed direct nodules along with data retrieved Genbank provides most update molecular epidemiology demonstrates that no more mosaic variant observed, is currently rise region its own patterns monophyletic evolution. These discoveries may help future investigations aimed at epidemiological surveillance tracking context identified lineages worldwide.

Язык: Английский

Процитировано

0
Outbreak of recombinant lumpy skin disease virus in yaks: high mortality and systemic pathogenesis in Qinghai-Tibet Plateau yak herds DOI Creative Commons

Jianwu Hu,

Yan Li, Xiaohu Zhang

и другие.

Frontiers in Veterinary Science, Год журнала: 2025, Номер 12

Опубликована: Май 21, 2025

The emergence of recombinant Lumpy Skin Disease Virus (LSDV) strains in Asia has led to outbreaks marked by severe skin nodules, high transmissibility, and transboundary spread, resulting significant economic losses cattle industries China neighboring countries. Qinghai-Tibet Plateau, historically a natural barrier against viral incursions, recently experienced increasing LSDV cases yaks (Bos grunniens). Current study elucidates the threat posed through clinical, pathological, molecular analyses. Field observations revealed infected exhibited fever, dyspnea, cutaneous pox lesions, lymphadenopathy, mucosal lesions. Viral DNA detection showed 100% positivity samples (6/6), 53.33% (8/15) nasal swabs, 33.33% (5/15) anal with an overall mortality rate 46.67% (7/15). Necropsy identified respiratory digestive system including tracheal congestion, pulmonary hemorrhagic plaques, ruminal serosal masses. Histopathology demonstrated dermal vasculitis, lymphocytic infiltration, inclusion bodies. Immunohistochemistry localized antigens hair follicle epithelia macrophages. Phylogenetic analysis positioned yak-derived strain (LSDV/China/GS/Yak) within Cluster 1.2 subclade homology circulating East/Southeast but differing from non-recombinant Indian strains. results emphasize increased pathogenicity plateau convey critical need for region-specific control strategies.

Язык: Английский

Процитировано

0