Advances in whole genome sequencing for foodborne pathogens: implications for clinical infectious disease surveillance and public health
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Апрель 28, 2025
Foodborne
outbreaks
affecting
millions
of
people
worldwide
are
a
significant
and
growing
global
health
threat,
exacerbated
by
the
emergence
new
increasingly
virulent
foodborne
pathogens.
Traditional
methods
detecting
these
outbreaks,
including
culture-based
techniques,
serotyping
molecular
such
as
real-time
PCR,
still
widely
used.
However,
approaches
often
lack
precision
resolution
required
to
definitively
trace
source
an
outbreak
distinguish
between
closely
related
strains
Whole
genome
sequencing
(WGS)
has
emerged
revolutionary
tool
in
investigations,
providing
high-resolution,
comprehensive
genetic
data
that
allows
accurate
species
identification
strain
differentiation.
WGS
also
facilitates
detection
virulence
antimicrobial
resistance
(AMR)
genes,
critical
insight
into
potential
pathogenicity,
treatment/control
options
risks
spreading
This
capability
enhances
surveillance,
tracing
risk
assessment,
making
integrated
component
public
surveillance
systems.
Despite
its
advantages,
widespread
implementation
faces
several
pressing
challenges,
high
costs,
need
for
specialized
bioinformatics
expertise,
limited
computational
infrastructure
resource-constrained
settings,
standardization
data-sharing
frameworks
across
regulatory
agencies.
Addressing
barriers
is
crucial
maximizing
impact
on
disease
surveillance.
Even
so,
emerging
vital
food
safety
health,
become
gold
standard
been
recognized
authorities
USA,
European
Union,
Australia
China,
example.
review
highlights
role
Язык: Английский
Comparative genomic analysis of Multi-Drug Resistance and Virulence Determinants of Escherichia coliSKN 649 and Staphylococcus ureilyticusSKN 217 isolated and characterized from milk and milk products in Anand, Gujarat, India
International Dairy Journal,
Год журнала:
2025,
Номер
unknown, С. 106316 - 106316
Опубликована: Июнь 1, 2025
Язык: Английский