Matrine Restores Colistin Efficacy Against mcr-1-Carrying Escherichia coli
Molecules,
Год журнала:
2025,
Номер
30(10), С. 2122 - 2122
Опубликована: Май 11, 2025
The
emergence
of
mcr-1-mediated
colistin
resistance
has
become
a
critical
global
health
concern,
highlighting
the
urgent
need
for
innovative
approaches
to
restore
colistin’s
therapeutic
potential.
In
this
study,
we
evaluated
antibacterial
activity
four
matrine-type
alkaloids—namely,
matrine,
oxymatrine,
sophocarpine,
and
sophoramine—against
mcr-1-positive
Escherichia
coli.
While
these
alkaloids
showed
limited
efficacy
when
used
alone,
combination
matrine
with
exhibited
remarkable
synergistic
effects,
as
demonstrated
by
checkerboard
assays
time-kill
curve
analyses.
matrine–colistin
caused
minimal
erythrocyte
damage
while
effectively
attenuating
development
in
vitro.
This
synergy
was
further
corroborated
murine
infection
model,
where
significantly
reduced
bacterial
loads
target
tissues.
Mechanistic
studies
revealed
that
enhances
antimicrobial
disrupting
membrane
integrity,
increasing
intracellular
accumulation,
triggering
reactive
oxygen
species-mediated
oxidative
damage.
Collectively,
findings
highlight
potential
promising
adjuvant
overcome
resistance,
providing
novel
approach
address
challenge
infections
cause
multidrug-resistant
Gram-negative
bacteria.
Язык: Английский
Design, synthesis and antifungal activity of novel matrine-hydroxamic acid derivatives containing benzene sulfonamide
Suzhen Yan,
Jamal A.H. Kowah,
Qingfeng Long
и другие.
RSC Advances,
Год журнала:
2025,
Номер
15(21), С. 16510 - 16524
Опубликована: Янв. 1, 2025
Novel
matrine
derivative
10g
exhibits
superior
anti-
C.
albicans
activity
versus
fluconazole
by
inhibiting
biofilm
formation
and
disrupting
mature
biofilms,
potentially
targeting
SAP
protein.
Язык: Английский