Biofilm-Associated Candidiasis: Pathogenesis, Prevalence, Challenges and Therapeutic Options DOI Creative Commons

Valerie Amann,

Ann‐Kathrin Kissmann, Carolina Firacative

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(4), С. 460 - 460

Опубликована: Март 25, 2025

The rising prevalence of fungal infections, especially those caused by Candida species, presents a major risk to global health. With approximately 1.5 million deaths annually, the urgency for effective treatment options has never been greater. spp. are leading cause invasive significantly impacting immunocompromised patients and in healthcare settings. C. albicans, parapsilosis emerging species auris categorized as highly dangerous because their pathogenic potential increasing drug resistance. This review comparatively describes formation microbial biofilms both bacterial origin, including pathogens, thereby creating novel focus. Biofilms can further complicate treatment, these structures provide enhanced resistance antifungal therapies. Traditional agents, polyenes, azoles echinocandins, have shown effectiveness, yet development continues rise, necessitating exploration therapeutic approaches. Antimicrobial peptides (AMPs) such anti-biofilm Pom-1 Cm-p5 originally isolated from snails represent promising candidates due unique mechanisms action neglectable cytotoxicity. article discusses challenges posed characteristics important role virulence new like AMPs.

Язык: Английский

Biofilm-Associated Candidiasis: Pathogenesis, Prevalence, Challenges and Therapeutic Options DOI Creative Commons

Valerie Amann,

Ann‐Kathrin Kissmann, Carolina Firacative

и другие.

Pharmaceuticals, Год журнала: 2025, Номер 18(4), С. 460 - 460

Опубликована: Март 25, 2025

The rising prevalence of fungal infections, especially those caused by Candida species, presents a major risk to global health. With approximately 1.5 million deaths annually, the urgency for effective treatment options has never been greater. spp. are leading cause invasive significantly impacting immunocompromised patients and in healthcare settings. C. albicans, parapsilosis emerging species auris categorized as highly dangerous because their pathogenic potential increasing drug resistance. This review comparatively describes formation microbial biofilms both bacterial origin, including pathogens, thereby creating novel focus. Biofilms can further complicate treatment, these structures provide enhanced resistance antifungal therapies. Traditional agents, polyenes, azoles echinocandins, have shown effectiveness, yet development continues rise, necessitating exploration therapeutic approaches. Antimicrobial peptides (AMPs) such anti-biofilm Pom-1 Cm-p5 originally isolated from snails represent promising candidates due unique mechanisms action neglectable cytotoxicity. article discusses challenges posed characteristics important role virulence new like AMPs.

Язык: Английский

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