Secondary metabolites and biodiversity of actinomycetes

Journal of Genetic Engineering and Biotechnology, Год журнала: 2021, Номер 19(1), С. 72 - 72

Опубликована: Май 12, 2021

The ability to produce microbial bioactive compounds makes actinobacteria one of the most explored microbes among prokaryotes. secondary metabolites are known for their role in various physiological, cellular, and biological processes.Actinomycetes widely distributed natural ecosystem habitats such as soil, rhizosphere actinmycorrhizal plants, hypersaline limestone, freshwater, marine, sponges, volcanic cave-hot spot, desert, air, insects gut, earthworm castings, goat feces, endophytic actinomycetes. important features that they have specific producers: diverse bioactivities unique chemical structures. Actinomycetes represent a source biologically active like antibiotics, biopesticide agents, plant growth hormones, antitumor compounds, antiviral pharmacological pigments, enzymes, enzyme inhibitors, anti-inflammatory single-cell protein feed, biosurfactant.Further highlight derived from can be applied wide range industrial applications biomedicines ecological habitat is under-explored yet investigated unknown, rare actinomycetes diversity.

Язык: Английский

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Plant Growth Promoting Actinobacteria, the Most Promising Candidates as Bioinoculants?

Frontiers in Agronomy, Год журнала: 2022, Номер 4

Опубликована: Март 21, 2022

Plant Growth Promoting Bacteria (PGPBs) are a strong ally for sustainable agriculture. They offer an interesting alternative to chemical fertilizers and pesticides. Many microorganisms have been widely documented their PGPR traits, but actinobacterial microbes which increasingly only these two past decades ability promote plant growth. Their action on health yield could be either direct, indirect or both. This review will cover articles that published Actinobacteria PGP highlighting the involved mechanisms reveal potential as microbial fertilizers. Possible strategies encourage use bioinoculants also discussed.

Язык: Английский

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Actinomycetes – The microbial machinery for the organic-cycling, plant growth, and sustainable soil health

Biocatalysis and Agricultural Biotechnology, Год журнала: 2020, Номер 31, С. 101893 - 101893

Опубликована: Дек. 17, 2020

Язык: Английский

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Into the Unknown: Microbial Communities in Caves, Their Role, and Potential Use

Microorganisms, Год журнала: 2022, Номер 10(2), С. 222 - 222

Опубликована: Янв. 20, 2022

Caves have been an item of amateur and professional exploration for many years. Research on the karst caves has revealed great diversity bacteria, algae, fungi living stone walls speleothems, in mud puddles or sediments. They become source interest various research groups including geologists, chemists, ecologists, microbiologists. The adaptations cave-dwelling organisms applied to their survival are complex some properties show potential be used areas human life. Secondary metabolites produced by cave's bacteria strong antimicrobial, anti-inflammatory, anticancer properties. Furthermore, that can induce mineral precipitation could construction industry neutralization radioisotopes. In this review we focus algae present cave ecosystems, role shaping such specific environment, biotechnological medical potential.

Язык: Английский

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Shedding light on the composition of extreme microbial dark matter: alternative approaches for culturing extremophiles

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Июнь 2, 2023

More than 20,000 species of prokaryotes (less 1% the estimated number Earth's microbial species) have been described thus far. However, vast majority microbes that inhabit extreme environments remain uncultured and this group is termed "microbial dark matter." Little known regarding ecological functions biotechnological potential these underexplored extremophiles, representing a untapped uncharacterized biological resource. Advances in cultivation approaches are key for detailed comprehensive characterization roles shaping environment and, ultimately, their exploitation, such as extremophile-derived bioproducts (extremozymes, secondary metabolites, CRISPR Cas systems, pigments, among others), astrobiology, space exploration. Additional efforts to enhance culturable diversity required due challenges imposed by culturing plating conditions. In review, we summarize methods technologies used recover environments, while discussing advantages disadvantages associated with each approaches. Additionally, review describes alternative strategies retrieve novel taxa unknown genes, metabolisms, roles, ultimate goal increasing yields more efficient bio-based products. This summarizes unveil hidden microbiome discusses directions future studies matter its applications biotechnology astrobiology.

Язык: Английский

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Unveiling novel features and phylogenomic assessment of indigenous Priestia megaterium AB-S79 using comparative genomics

Microbiology Spectrum, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

ABSTRACT Priestia megaterium strain AB-S79 isolated from active gold mine soil previously expressed in vitro heavy metal resistance and has a 5.7 Mb genome useful for biotechnological exploitation. This study used web-based bioinformatic resources to analyze P. genomic relatedness, decipher its secondary metabolite biosynthetic gene clusters (BGCs), better comprehend taxa. Genes were highly conserved across the 14 P . genomes examined here. The pangenome reflected total of 61,397 protein-coding genes, 59,745 homolog protein family hits, 1,652 singleton hits. There also 7,735 families, including 1,653 families 6,082 families. OrthoVenn3 comparison sequences with 13 other strains, 7 spp., 6 Bacillus spp. highlighted AB-S79’s unique evolutionary trait. antiSMASH identified two key transcription factor binding site regulators genome: zinc-responsive repressor (Zur) antibiotic production activator (AbrC3), plus putative enzymes biosynthesis terpenes ranthipeptides. harbors BGCs siderophores (synechobactins schizokinens), phosphonate, dienelactone hydrolase protein, phenazine (phzF), which is significant this study. Phosphonate particularly showed specificity sp. validating effect expansion contraction. looks be viable source value-added compounds. Thus, contributes theoretical framework systematic metabolic genetic exploitation sp., value-yielding strains. IMPORTANCE explores microbial natural product discovery using mining, focusing on Key findings highlight potential , AB-S79, applications. research shows limited output Africa, emphasizing importance native AB-S79. Additionally, underlines strain’s diverse capabilities, reinforcing suitability as model cell factories foundational role future

Язык: Английский

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Bioaugmentation with a defined bacterial consortium: A key to degrade high molecular weight polylactic acid during traditional composting

Bioresource Technology, Год журнала: 2022, Номер 367, С. 128237 - 128237

Опубликована: Ноя. 1, 2022

Язык: Английский

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Penicillium citrinum, a Drought-Tolerant Endophytic Fungus Isolated from Wheat (Triticum aestivum L.) Leaves with Plant Growth-Promoting Abilities

Current Microbiology, Год журнала: 2023, Номер 80(5)

Опубликована: Апрель 15, 2023

Язык: Английский

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Life on the Edge: Bioprospecting Extremophiles for Astrobiology

Journal of the Indian Institute of Science, Год журнала: 2023, Номер 103(3), С. 721 - 737

Опубликована: Май 19, 2023

Abstract Discovering exoplanets and satellites in habitable zones within beyond our solar system has sparked intrigue planetary setting varieties that could support life. Based on understanding of life Earth, we can shed light the origin, evolution, future Earth-like organisms galaxy predict extinct or extant extraterrestrial Hence, extremophiles thriving mimic outer space environments are particularly interesting as they exhibit traits preponderate comprehension regarding possibility elsewhere situ detection. Additionally, many have been used for astrobiological research model to unveil native alien possible life-produced metabolites outside Earth. Laboratory-based simulation chambers this condition, helping researchers study Earth near identical conditions understand molecular mechanisms survival. This review summarizes relevant studies with isolated microorganisms from extreme analog environments, harnessing them promising candidates pursuing potentialities other bodies. We also highlight necessity environmental chamber approaches mimicking habitats.

Язык: Английский

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BGC Atlas: a web resource for exploring the global chemical diversity encoded in bacterial genomes

Nucleic Acids Research, Год журнала: 2024, Номер 53(D1), С. D618 - D624

Опубликована: Окт. 29, 2024

Abstract Secondary metabolites are compounds not essential for an organism’s development, but provide significant ecological and physiological benefits. These have applications in medicine, biotechnology agriculture. Their production is encoded biosynthetic gene clusters (BGCs), groups of genes collectively directing their biosynthesis. The advent metagenomics has allowed researchers to study BGCs directly from environmental samples, identifying numerous previously unknown encoding unprecedented chemistry. Here, we present the BGC Atlas (https://bgc-atlas.cs.uni-tuebingen.de), a web resource that facilitates exploration analysis diversity metagenomes. identifies publicly available datasets, offering centralized database interface metadata-aware cluster families (GCFs). We analyzed over 35 000 datasets MGnify, nearly 1.8 million BGCs, which were clustered into GCFs. showed ribosomally synthesized post-translationally modified peptides most abundant compound class, with GCFs exhibiting high specificity. believe our tool will enable easily explore analyze significantly enhancing understanding bacterial secondary metabolites, promote identification evolutionary factors shaping potential microbial communities.

Язык: Английский

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