Insights for COVID-19 in 2023

Revista Española de Quimioterapia, Год журнала: 2022, Номер 36(2), С. 114 - 124

Опубликована: Дек. 12, 2022

Predictions for a near end of the pandemic by World Health Organization should be interpreted with caution. Current evidence indicates that efficacy fourth dose classical mRNA vaccines (BT162b2 or mRNA-1273) is low and short-lived in preventing SARS-CoV-2 infection its predominant variant (Omicron). However, high against severe symptomatic infection, hospitalization death. The new being introduced are bivalent active Omicron variants. Potential to coming year include vaccine based on recombinant protein emulates receptor binding domain Spike under development Spanish company Hipra, as well nasal oral administration. Available information suggests COVID-19 can administered association influenza vaccination without particular complications. New drugs COVID-19, both antiviral anti-inflammatory, investigation, but this does not seem case monoclonal antibodies. indication use masks some circumstances will maintained next view accumulation scientific data their efficacy. Finally, long COVID Post-COVID syndrome may continue affect very proportion patients who have had disease, requiring combined diagnostic therapeutic resources.

Язык: Английский

---

Omicron Variant of SARS-CoV-2: An Indian Perspective of Vaccination and Management

Vaccines, Год журнала: 2023, Номер 11(1), С. 160 - 160

Опубликована: Янв. 11, 2023

Omicron variants have highly influenced the entire globe. It has a high rate of transmissibility, which makes its management tedious. There are various subtypes omicron, namely BA.1, BA.2, BA.3, BA.4, and BA.5. Currently, one omicron subvariant BF.7 is also immersed in some parts India. Further studies required for better understanding new immersing SARS-CoV-2 omicron. They differ mutation spike proteins, alters their attachment to host receptor hence modifies virulence adaptability. Delta great disastrous influence on world, especially While overcoming it, another mutant catches pace. The Indian population affected by variants. diagnosis system against COVID-19. demanded forcemeat health care system, both qualitatively quantitively, cope with wave. alteration protein, major target vaccines, leads varied immunization subvariants. efficacy vaccines variant was questioned. Every vaccine had different shielding effect variant. hesitancy vaccination prevalent factor India that might contributed outbreak. prevalence monkeypox, tomato flu shared similarities distinct features when compared population. This review emphasizes changes brings it how outrage this dangerous

Язык: Английский

---

Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors

Journal of Medicinal Chemistry, Год журнала: 2022, Номер 65(24), С. 16902 - 16917

Опубликована: Дек. 7, 2022

The spread of SARS-CoV-2 keeps threatening human life and health, small-molecule antivirals are in demand. main protease (Mpro) is an effective highly conserved target for anti-SARS-CoV-2 drug design. Herein, we report the discovery potent covalent non-peptide-derived Mpro inhibitors. A series compounds with a piperazine scaffold containing different warheads were designed synthesized. Among them, GD-9 was identified as most compound significant enzymatic inhibition (IC50 = 0.18 μM) good antiviral potency against (EC50 2.64 μM), similar to that remdesivir 2.27 μM). Additionally, presented favorable selectivity versus cysteine proteases. X-ray co-crystal structure confirmed our original design concept showing covalently binds active site Mpro. Our nonpeptidic inhibitors provide basis future development more efficient COVID-19 therapeutics.

Язык: Английский

---

Assessing acceptability of the fourth dose against COVID-19 among Chinese adults: A population-based survey

Human Vaccines & Immunotherapeutics, Год журнала: 2023, Номер 19(1)

Опубликована: Янв. 2, 2023

Coronavirus disease 2019 (COVID-19) has wreaked havoc across the globe for approximately three years. Vaccination is a key factor to ending this pandemic, but its protective effect diminishes over time. A second booster dose at right time needed. To explore willingness receive fourth of COVID-19 vaccine and influencing factors, we commenced national, cross-sectional anonymous survey in mainland China among people aged 18 above from October 24 November 7, 2022. total 3,224 respondents were eventually included. The acceptance rate was 81.1% (95% CI: 79.8–82.5%), while it 72.6% 71.1–74.2%) heterologous booster. Confidence current domestic situation effectiveness previous vaccinations, uncertainty about extra protection main reasons hesitancy. Perceived benefit (aOR = 1.29, 95% 1.159–1.40) cues action 1.73, 1.60–1.88) positively associated with acceptance, whereas perceived barriers 0.78, 0.72–0.84) self-efficacy 0.79, 0.71–0.89) both negatively it. Additionally, sex, age, vaccination history, social media, satisfaction government's response also factors affecting intention. Factors intention similar results. It profound theoretical practical significance clarify population's vaccinate advance relevant subsequent development promotion fourth-dose strategies.

Язык: Английский

---

Dynamic variations in COVID-19 with the SARS-CoV-2 Omicron variant in Kazakhstan and Pakistan

Infectious Diseases of Poverty, Год журнала: 2023, Номер 12(1)

Опубликована: Март 15, 2023

The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) and Omicron variant presents a formidable challenge for control prevention worldwide, especially low- middle-income countries (LMICs). Hence, taking Kazakhstan Pakistan as examples, this study aims to explore COVID-19 transmission with at different contact, quarantine test rates.A dynamic model was applied, population segmented, three time stages were established: initial outbreak, period of stabilization, second outbreak. impact testing on are analyzed in five scenarios analysis their impacts disease. Four statistical metrics employed quantify model's performance, including correlation coefficient (CC), normalized absolute error, root mean square error distance between indices simulation observation (DISO).Our has high performance simulating CC values greater than 0.9 DISO less 0.5. Compared present measures (baseline), decreasing (increasing) contact rates or increasing (decreasing) quarantined can reduce (increase) peak daily new cases forward (delay) value times (decreasing 842 days Kazakhstan). weak. When start stage II is 6 days, more 8 5 rate Pakistan, respectively (29,573 vs. 3259; 7398 1108). III contradictory those II.For two LMICs, stronger be effective combating COVID-19. Therefore, transmission, strict management movement should employed. Moreover, timely application these strategies also plays key role control.

Язык: Английский

---

The trend of phylogenetic and epitope variations of SARS-CoV-2 Omicron sub-lineages in Iran

Frontiers in Microbiology, Год журнала: 2025, Номер 15

Опубликована: Янв. 29, 2025

Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a significant public health issue worldwide in recent years. The most recently circulating variant of SARS-CoV-2, Omicron, and its rapid evolution into various sub-lineages have raised concerns regarding the effects immunity on virus epitopes, human population. present study evaluated compared these important variations among different Omicron Iran. Methodology From October 2023 to August 2024, high coverage whole genome sequences 49 SARS-CoV-2 strains were subjected phylogenetic analysis evaluation B cell, CD4 + , CD8 T cell epitopes Iran National Influenza Centre. Results tree exhibited eight Nextstrain clades (21L, 22F, 23B, 23H, 23D, 24A, 24B, 24C) 48 studied strains, one recombinant strain (XDK.1). all revealed 31, 65, 78%, conservation, respectively. low conservation rate underscored escaping from neutralizing humoral immunity. considerably preserved across major sub-lineages. Conservation levels varied based epitope class (higher for vs. ), protein non-spike spike), 21L, 24B 24A 24C). Conclusion Herein, increased is probably attributable shorter length peptides associated with epitopes. T-cell proteins this highlighted importance cell-mediated suggested that might be more attractive targets future vaccines.

Язык: Английский

---

Duration of SARS-CоV-2 virus shedding in COVID-19 patients with HIV infection

HIV Infection and Immunosuppressive Disorders, Год журнала: 2025, Номер 16(4), С. 99 - 106

Опубликована: Фев. 14, 2025

The aim: to describe the duration of SARS-CoV-2 virus shedding in patients with HIV infection and identify factors associated prolonged viral shedding. Materials methods: a prospective study, clinical laboratory characteristics COVID-19 were compared 170 patients, titers neutralizing antibodies SARSCoV-2 identified 68 patients; pathogen genotyping was performed 36 patients. Statistical analysis carried out using IBM SPSS Statistics package. Results discussion: there no significant differences varying severity grade COVID-19; negative relationship between titer revealed. In 35.9% (61 persons), persistence lasted for more than 21 days, this group characterized by an unfavorable course absence ART, significantly lower CD4 cell values higher load blood. Virus shown be longer B.1.1 strain versus other gene variants. Mutations Spike protein that increase infectious ability reduce its sensitivity found 4 Conclusion: did not affect infection. Long-term discovered severe immunodeficiency (CD4<200 cl/μl) ART. Patients pose epidemiological risk regard developing new mutational variants pathogen.

Язык: Английский

---

Modeling the COVID-19 Dynamics with Omicron Variant, Non-pharmaceutical Interventions, and Environmental Contamination

Differential Equations and Dynamical Systems, Год журнала: 2025, Номер unknown

Опубликована: Фев. 22, 2025

Язык: Английский

---

Generative adversarial networks based synthetic biology: A promising approach to sars-cov-2 mutations prediction

Engineering Applications of Artificial Intelligence, Год журнала: 2025, Номер 148, С. 110395 - 110395

Опубликована: Март 3, 2025

Язык: Английский

---

Postoperative cardiopulmonary complications in children with preoperative Omicron SARS-CoV-2 variants infection: a single-center retrospective cohort study

BMC Pediatrics, Год журнала: 2025, Номер 25(1)

Опубликована: Март 3, 2025

The purpose of this study was to investigate: (1) the incidence cardiopulmonary complications within 30 days after surgery in pediatric patients with preoperative Omicron variants infection, (2) mortality, and (3) their possible risk factors. This retrospective included a consecutive patient cohort who underwent elective non-cardiac for any indication Pediatric Department our hospital between November 2022 February 2023. Cardiopulmonary mortality were compared pre-operative SARS-CoV-2 infection (Omicron infected group) those without (the uninfected 90-day before surgery. evaluated demographic data related clinical factors by analyzing records. Our 502 patients, which 194 (38.65%) had diagnosis. mean duration definite 31.28 ± 10.19 days. In study, pulmonary 1.59% (8/502 patients), no cardiac complication or found 30-day postoperative follow-up. group significantly higher (7/194, 3.61%) (1/308, 0.32%) (p = 0.006). After adjusted other factors, it that 4 weeks (OR 17.84, 95% CI: 1.25-255.35, p 0.034), BMI 1.26, 1.02–1.55, ASA physical status grade III-V 17.35, 1.19–253.80, 0.037), abnormal chest radiograph 60.07, 1.92-1878.21, 0.020) independent may heighten children undergoing It is advisable schedule at least variants.

Язык: Английский

---