Beyond the microbiome: unraveling gut dysbiosis and its impact on systemic lupus erythematosus

Alexandria Journal of Medicine, Год журнала: 2025, Номер 61(1), С. 1 - 10

Опубликована: Фев. 6, 2025

Язык: Английский

---

Linking microbial communities to rheumatoid arthritis: focus on gut, oral microbiome and their extracellular vesicles

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Апрель 16, 2025

Rheumatoid arthritis (RA) is a severe, chronic autoimmune disease affecting approximately 1% of the global population. Research has demonstrated that microorganisms play crucial role in onset and progression RA. This indicates disruption immune homeostasis may originate from mucosal sites, such as gut oral cavity. In intestines patients preclinical stage RA, an increased abundance Prevotella species with strong association to was observed. cavity, infections by Porphyromonas gingivalis Aggregatibacter actinomycetemcomitans can mediate production anti-citrullinated protein antibodies (ACPAs), potentially contributing RA pathogenesis. Nevertheless, no single bacterial been consistently identified primary driver review will discuss connection between bacteria development arthritis. Additionally, it explores extracellular vesicles (bEVs) inducing inflammation their potential pathogenic roles

Язык: Английский

---

Studies on the Probiotic, Adhesion and Induction Properties of Artisanal Lactic Acid Bacteria: To Customize a Gastrointestinal Niche to Trigger Anti-Obesity Functions

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июнь 24, 2024

Aims: The primary goals of this work are to explore the potential probiotic LAB's mucin/mucus layer thickening properties and identify anti-obesity candidate strains that improve appropriate habitat for use with Akkermansia group population in future. Methods Results: The HT-29 cell binding, antimicrobial properties, adhesion layer, growth presence mucin, stability during in vitrogastrointestinal (GI) conditions, biofilm formation, thickness increment abilities were all assessed artisanal LAB strains. Sixteen out 40 chosen further analysis based on their ability withstand GI conditions. Thirteen maintained vitality simulated intestinal fluid, whereas majority displayed high viability gastric juice simulation. Furthermore, 35.2-65.4% those 16 bacteria adhered mucin layer. Besides, different lactate levels produced, Streptococcus thermophilusUIN9 exhibited highest development. Also, a 50 mM concentration had been injected originally, Lacticaseibacillus casei NRRL-B 441 maximum amount (321.6 µg/mL). Conclusions: Two isolates olive from Lactiplantibacillus plantarum as prototype candidates; these did not consume sugars. Significance Impact Study: Probiotic attachment colonic mucosa its stimulate cells secrete mucus critical mechanisms may support development Akkermansia.

Язык: Английский

---

Testosterone treatment impacts the intestinal microbiome of transgender individuals

mSphere, Год журнала: 2024, Номер unknown

Опубликована: Сен. 10, 2024

ABSTRACT Medical modulation of sex hormone levels is a cornerstone treatment for many conditions that impact well-being, including cancer, fertility/infertility, gender dysphoria, and chronic metabolic diseases such as diabetes obesity. The microbial residents the intestine, known microbiota, interact with hormones in there correlative evidence this interaction bidirectional. Based on these published findings, we hypothesized transgender individuals receiving exogenous testosterone part their gender-affirming medical might undergo changes intestinal microbiome. To test this, collected 26 stool samples from nine before up to 8 months after initiation subjected metagenomic analysis. While no species were significantly associated duration therapy, pathways generate glutamate increased abundance, while those consume decreased. Glutamate precursor arginine, increase arginine its metabolites plasma. We hypothesize increases uptake by enterocytes, thus decreasing access microbiota amino acid. pilot study establishes therapy microbiome, more comprehensive necessary establish testosterone-driven shifts metatranscriptome, metabolome, plasma metabolome. IMPORTANCE human intestine inhabited large community microbes Members microbiome diet along host. Thus, metabolomes host microbe are intricately linked. Testosterone alters In particular, positively correlated. investigate analyzed metagenomes treatment. project, found modest structure but an abundance spare consumption. propose uses amount available

Язык: Английский

---

Studies on the Probiotic, Adhesion, and Induction Properties of Artisanal Lactic Acid Bacteria: to Customize a Gastrointestinal Niche to Trigger Anti-obesity Functions

Probiotics and Antimicrobial Proteins, Год журнала: 2024, Номер unknown

Опубликована: Окт. 9, 2024

Язык: Английский

---

Lactobacillus rhamnosus LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway

Food & Function, Год журнала: 2024, Номер unknown

Опубликована: Дек. 18, 2024

Lactobacillus rhamnosus LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by modulating gut microbiota and inhibiting TLR9/NF-κB signaling pathway.

Язык: Английский

---