Foods,
Год журнала:
2025,
Номер
14(4), С. 619 - 619
Опубликована: Фев. 13, 2025
The
consumption
of
wampee
has
traditionally
been
utilized
to
alleviate
gastrointestinal
inflammation
and
associated
disorders;
however,
its
exact
mechanism
remained
unknown.
aim
this
study
was
elucidate
the
therapeutic
efficacy
underlying
polyphenol
extract
(WPE)
in
dextran
sulfate
sodium
(DSS)-induced
ulcerative
colitis
(UC).
findings
revealed
that
WPE
alleviated
diverse
symptoms
UC,
regulated
various
inflammatory
cytokines,
effectively
protected
colon
tissue
structure
barrier
integrity,
thereby
inhibiting
LPS
translocation.
Moreover,
restored
richness
diversity
gut
microbiota
optimized
at
phylum
genus
levels,
causing
a
notable
improvement
short-
chain
fatty
acid
(SCFA)
metabolism,
particularly
acetic
acid,
propionic
butyric
acid.
Consequently,
demonstrated
suppress
LPS-induced
TLR4-p38
MAPK/NF-κB
signaling
pathway
by
modulating
SCFA
metabolism.
These
provided
theoretical
basis
for
use
as
potential
functional
natural
food
UC.
Foods,
Год журнала:
2025,
Номер
14(4), С. 651 - 651
Опубликована: Фев. 14, 2025
Red
mold
rice,
fermented
by
Monascus
spp.,
has
been
reported
to
modulate
gut
microbiota
composition
and
improve
metabolic
health.
Previous
studies
indicate
that
red
rice
can
reduce
cholesterol,
inhibit
hepatic
lipid
accumulation,
enhance
bile
acid
excretion,
while
also
altering
under
high-fat
dietary
conditions.
However,
it
remains
unclear
whether
these
effects
are
directly
due
Monascus-derived
products
modulating
or
a
consequence
of
improved
health
conditions,
which
indirectly
influence
microbiota.
This
study
aimed
evaluate
the
pilosus
SWM
008
its
components-monascin,
monascinol,
ankaflavin,
polysaccharides-on
in
rats
fed
normal
diet.
Over
eight
weeks,
physiological,
biochemical,
parameters
were
assessed.
Results
showed
no
significant
changes
body
weight
liver/kidney
function,
confirming
safety.
Gut
analysis
revealed
monascin,
polysaccharides
significantly
altered
increasing
relative
abundance
beneficial
bacteria,
such
as
Akkermansia
muciniphila,
Ligilactobacillus
murinus,
Duncaniella
dubosii.
Functional
predictions
indicated
enhanced
vitamin
K2
biosynthesis,
nucleotide
metabolism,
other
pathways
linked
In
conclusion,
demonstrated
safety
effects,
suggesting
potential
functional
food
maintain
balance
Aging
is
a
key
contributor
of
morbidity
and
mortality
during
acute
viral
pneumonia.
The
potential
role
age-associated
dysbiosis
on
disease
outcomes
still
elusive.
In
the
current
study,
we
used
high-resolution
shotgun
metagenomics
targeted
metabolomics
to
characterize
SARS-CoV-2-associated
changes
in
gut
microbiota
from
young
(2-month-old)
aged
(22-month-old)
hamsters,
valuable
model
COVID-19.
We
show
that
age-related
dysfunctions
are
linked
severity
long-term
sequelae
older
hamsters.
Our
data
also
reveal
age-specific
composition
metabolic
activity
both
phase
(day
7
post-infection,
D7)
recovery
(D22)
infection.
Aged
hamsters
exhibited
most
notable
shifts
plasma
profiles.
Through
an
integrative
analysis
metagenomics,
metabolomics,
clinical
data,
identified
significant
associations
between
bacterial
taxa,
metabolites
markers
group.
On
D7
(high
load
lung
epithelial
damage)
D22
(body
weight
loss
fibrosis),
numerous
amino
acids,
acid-related
molecules,
indole
derivatives
were
found
correlate
with
markers.
particular,
persistent
decrease
phenylalanine,
tryptophan,
glutamic
acid,
indoleacetic
acid
animals
positively
correlated
poor
body
and/or
fibrosis
by
D22.
younger
several
taxa
(Eubacterium,
Oscillospiraceae,
Lawsonibacter)
(carnosine
cis-aconitic
acid)
associated
mild
outcomes.
These
findings
support
need
for
microbiome-targeting
strategies
more
effectively
manage
pneumonia
Veterinary Sciences,
Год журнала:
2025,
Номер
12(4), С. 354 - 354
Опубликована: Апрель 10, 2025
This
study
aims
to
explore
the
therapeutic
potential
of
Angelicae
Pubescentis
Radix
(APR),
a
traditional
Chinese
medicine
that
is
widely
known
for
its
anti-inflammatory,
anti-oxidative,
and
anti-microbial
properties,
using
mouse
model.
In
this
study,
30
mice
were
selected
divided
into
three
groups:
control
group
(CD),
infection
(ED),
treatment
(TD).
Mice
in
TD
gavaged
with
APR
oil
(0.15
mL/kg/day)
20
days,
while
CD
ED
received
an
equal
volume
normal
saline.
On
21st
day,
infected
multi-drug-resistant
E.
coli
(1
×
107
CFU/mL)
derived
from
diarrheal
yak.
Twenty-four
hours
later,
all
euthanized,
blood,
organs,
intestinal
samples
collected
analysis.
The
results
sections
bacterial
load
revealed
significantly
reduced
(p
<
0.05)
both
injury.
Serum
analysis
indicated
also
alleviated
inflammation
oxidative
stress
induced
by
infection.
Intestinal
microbiota
sequencing
further
showed
increased
abundance
probiotics
such
as
Ligilactobacillus,
Paludicola,
Blautia_A_1417806
enhancing
enrichment
functional
pathways
associated
antioxidant
defense.
conclusion,
effectively
alleviates
diseases
caused
infection,
promotes
growth
beneficial
bacteria,
improves
capacity
animals.
Additionally,
these
findings
confirm
APR’s
role
addressing
immediate
effects
rather
than
chronic
adaptations.
Future
studies
should
investigate
prolonged
beyond
acute
phase.
Schizophrenia Bulletin,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 18, 2025
Abstract
Background
and
Hypothesis
Abdominal
low-intensity
pulsed
ultrasound
(LIPUS)
stimulation
has
potential
as
a
novel
therapeutic
strategy
against
neuroinflammation
via
inhibition
of
inflammatory
responses
in
the
colon.
This
study
aimed
to
evaluate
whether
abdominal
LIPUS
could
alleviate
MK-801-induced
schizophrenia-like
negative
symptoms
through
gut–brain
communication.
Study
Design
Rats
administered
with
MK-801
were
treated
daily
for
5
days
either
or
Lactobacillus
plantarum
PS128,
while
another
group
MK-801-administered
rats
received
no
treatment.
Following
PS128
treatment,
underwent
behavioral
testing,
western
blot
analysis,
histological
examination.
Changes
gut
bacteria
composition
examined
16S
rRNA
sequencing
analysis.
Results
administration
reduced
NMDAR1
VGAT
expression
medial
prefrontal
cortex
(mPFC)
rats,
leading
an
imbalance
excitation/inhibition
(E/I)
ratio.
It
also
decreased
5-HT1AR
5-HT2AR
density,
resulting
concentrations
dopamine
serotonin
(5-HT).
induced
prepulse
inhibition,
anhedonia,
social
withdrawal
behaviors,
accompanied
by
reduction
microbiota
diversity.
effectively
lessened
diversity,
restored
NMDAR1,
5-HT1AR,
enhanced
dopaminergic
neuron
activity,
increased
5-HT
release
mPFC,
thereby
reversing
abnormalities.
Conclusions
These
results
suggest
that
alleviates
modulating
signaling
microbiota.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 25, 2024
The
modulation
of
intestinal
flora
by
various
polysaccharides
has
been
shown
to
mitigate
disease
progression.
Recent
research
reveals
a
significant
link
between
and
the
progression
mastitis.
This
study
demonstrates
that
oral
administration
