Enhancing curcumin stability and bioavailability through chickpea protein isolate–citrus pectin conjugate emulsions: Targeted delivery and gut microecology modulation
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
300, С. 140295 - 140295
Опубликована: Янв. 23, 2025
Язык: Английский
High-throughput point-of-care serum iron testing utilizing machine learning-assisted deep eutectic solvent fluorescence detection platform
Journal of Colloid and Interface Science,
Год журнала:
2024,
Номер
680, С. 389 - 404
Опубликована: Ноя. 17, 2024
Язык: Английский
Is it feasible to treat polycystic ovarian syndrome with or without insulin resistance using glucokinase activators as novel hypoglycaemic medications? A protocol for a systematic review and meta-analysis
BMJ Open,
Год журнала:
2024,
Номер
14(12), С. e088484 - e088484
Опубликована: Дек. 1, 2024
A
variety
of
hypoglycaemic
drugs
are
used
to
treat
polycystic
ovarian
syndrome
(PCOS),
but
their
efficacy
remains
insufficient.
Glucokinase
activators
(GKAs)
a
unique
class
medications
with
emerging
potential,
notably
in
significantly
reducing
insulin
resistance
(IR).
Nevertheless,
the
GKAs
treating
PCOS,
particularly
absence
or
presence
IR,
uncertain.
The
meta-analysis
protocol
aims
address
this
knowledge
gap,
furnish
evidence-based
data
support
potential
revisions
PCOS
treatment
guidelines
and
promote
utilisation
clinical
settings.
comprehensive
search
will
be
conducted
across
Cochrane
Central
Register
Controlled
Trials,
PubMed,
Web
Science,
Embase,
Medline,
Scopus,
CNKI,
Wanfang
VIP
databases
identify
randomised
controlled
trials
investigating
use
irrespective
IR.
encompass
all
available
studies
without
language
restrictions
cover
period
from
inception
each
database
10
April
2024.
Disputes
resolved
by
talking
third
expert
following
screening
articles
extraction
two
reviewers.
primary
outcomes
interest
changes
anthropometric
parameters,
menstrual
frequency,
sex
hormone
levels,
glucose
metabolism,
while
secondary
objectives
include
lipid
metabolism
adverse
events.
methodological
quality
study
assessed
using
Version
2
Collaboration
tool
for
assessing
Risk
Bias
(RoB
2.0),
Grade
Recommendations,
Assessment,
Development
Evaluation
(GRADE)
technique
assess
evidence
degree
recommendation.
duration
5
2024
2025.
Since
just
analyses
that
readily
public
does
not
directly
involve
patient
participation,
ethical
approval
is
necessary.
findings
made
being
published
medical
journal
subject
peer
review.
CRD42024535633.
Язык: Английский
Fur-mediated regulation of hydrogen sulfide synthesis, stress response, and virulence in Edwardsiella piscicida
Riyu Zhang,
Yifan Bu,
Yuanxing Zhang
и другие.
Microbiological Research,
Год журнала:
2024,
Номер
284, С. 127735 - 127735
Опубликована: Апрель 25, 2024
Язык: Английский
A multi-omics approach reveals that lotus root polysaccharide iron ameliorates iron deficiency-induced testicular damage by activating PPARγ to promote steroid hormone synthesis
Journal of Advanced Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 1, 2024
Язык: Английский
Do probiotics and iron supplementation have any impact on element distribution in rat kidneys? - bioimaging by laser ablation inductively coupled plasma mass spectrometry
Talanta,
Год журнала:
2024,
Номер
283, С. 127112 - 127112
Опубликована: Окт. 28, 2024
Язык: Английский
Clinical efficacy of washed microbiota transplantation on metabolic syndrome and metabolic profile of donor outer membrane vesicles
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 19, 2024
Object
To
clarify
the
clinical
efficacy
of
washed
microbiota
transplantation
(WMT)
for
metabolic
syndrome
(MetS),
and
explore
differences
in
profile
bacterial
outer
membrane
vesicles
(OMVs)
donor
fecal
bacteria
suspension
received
by
MetS
patients
with
good
poor
outcomes,
to
construct
a
predictive
model
WMT
using
differential
metabolites.
Methods
Medical
data
65
who
had
completed
at
least
2
courses
from
2017.05
2023.07
were
collected.
Fecal
donors
collected,
treated
during
this
period
collected
as
well.
The
changes
BMI,
blood
glucose,
lipids,
pressure
other
indicators
before
after
compared.
OMVs
isolated
off-target
metabolomic
sequencing
was
performed
Liquid
Chromatograph
Mass
Spectrometer
(LC–MS).
Results
Compared
baseline,
Body
mass
index
(BMI),
Systolic
(SBP)
Diastolic
(DBP)
showed
significant
decreases
1st
(short-term)
2nd
(medium-term)
courses,
fasting
glucose
(FBG)
also
session.
There
difference
between
Marked
Response
Moderate
OMVs.
It
that
960
metabolites
significantly
up-regulated
439
down-regulated.
ROC
suggested
9-carboxymethoxymethylguanine,
AUC
=
0.8127,
95%
CI
[0.6885,
0.9369],
most
potent
metabolite
predicting
available
efficacy.
Conclusion
short-term
medium-term
MetS.
structure
level
9-Carboxy
methoxy
methylguanine
can
be
predictor
treatment
Язык: Английский