Celebrating the fifth edition of the International Symposium on Fungal Stress – ISFUS, a decade after its 2014 debut
Fungal Biology,
Год журнала:
2025,
Номер
unknown, С. 101590 - 101590
Опубликована: Май 1, 2025
Язык: Английский
Epidemiology, antifungal susceptibility and biological characteristics of clinical Aspergillus fumigatus in a tertiary hospital
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Май 15, 2025
Azole
resistance
in
Aspergillus
fumigatus
poses
a
significant
clinical
challenge
globally.
In
this
study,
we
analyzed
307
A.
isolates
from
General
Hospital
of
Ningxia
Medical
University
China,
collected
between
July
2023
and
2024,
to
explore
their
susceptibility
profiles,
genotypic
characteristics
biological
traits.
The
overall
frequency
azole
among
province
was
found
be
1.20%
(7
azole-resistant
fumigatus,
designated
AF1-AF7),
each
exhibiting
distinct
phenotypes
terms
resistance,
spore
viability,
resilience
environmental
stress.
Among
these
strains,
the
cyp51A
mutations
predominantly
included
TR43/L98H,
while
hmg1
were
primarily
S212P/Y564H.
Additionally,
novel
discovered
cyp51B,
specifically
t-215c
point
mutation
base
deletion
(gatgccta)
-
213
206
region.
AF3
strain
demonstrated
highest
activity
anti-SDS
efficacy.
contrast,
AF1
AF2
strains
resistant
three
azoles
also
exhibited
Menadione,
similar
AF7.
Notably,
six
out
seven
displayed
NaCl
KCl,
indicating
strong
tolerance
saline
conditions.
These
findings
suggest
that
possess
varying
degrees
stressors,
implying
they
may
adapt
surroundings
through
different
evolutionary
pathways,
which
could
complicate
treatment
strategies.
Effective
surveillance
control
strategies
are
essential
widespread
prevalence
reduce
risk
infection
patients.
Язык: Английский
Genomic Insights into Fusarium verticillioides Diversity: The Genome of Two Clinical Isolates and Their Demethylase Inhibitor Fungicides Susceptibility
Pathogens,
Год журнала:
2024,
Номер
13(12), С. 1062 - 1062
Опубликована: Дек. 3, 2024
Fusarium
verticillioides
is
an
important
plant
pathogen
in
maize
and
other
cereals
that
seldom
detected
as
the
cause
of
human
fusariosis.
Here,
we
provide
analysis
available
diversity
F.
sequenced
worldwide
report
first
two
genome
assemblies
annotations
(including
mitochondrial
DNA)
from
clinical
settings.
05-0160
(IUM05-0160)
09-1037
(IUM09-1037)
strains
were
obtained
bone
marrow
blood
immunocompromised
patients,
respectively.
The
phylogenomic
confirmed
species
identity
our
strains.
Comparative
genomic
analyses
among
reannotated
genomes
(n
=
46)
did
not
lead
to
identification
unique
genes
specific
samples.
Two
subgroups
clade
also
identified
by
a
study.
Clinical
4)
positioned
multigene
phylogenetic
tree
without
any
correlation
between
host
branches,
grouping
with
plant-derived
To
investigate
existence
potential
fitness
advantage
strains,
compared
demethylase
inhibitor
fungicides
susceptibility
against
reference
7600,
showing,
on
average,
lower
agricultural
medical-used
antifungals.
A
significant
reduction
was
observed
for
itraconazole
tetraconazole,
which
might
be
explained
structural
changes
CYP51A
CYP51C
sequences.
By
providing
annotated
settings
comprehensive
their
mitogenomes,
this
study
can
serve
base
exploring
adaptation
capacities
infecting
different
kingdoms.
Язык: Английский