Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 11, 2024
The
increasing
health
and
environmental
risks
associated
with
synthetic
chemical
pesticides
necessitate
the
exploration
of
safer,
sustainable
alternatives
for
plant
protection.
This
study
investigates
a
novel
biosynthesized
antimicrobial
peptide
(AMP)
from
Lactiplantibacillus
argentoratensis
strain
IT,
identified
as
amino
acid
chain
PRKGSVAKDVLPDPVYNSKLVTRLINHLMIDGKRG,
its
efficacy
in
controlling
bacterial
wilt
(BW)
disease
tomato
(
Solanum
lycopersicum
)
caused
by
Ralstonia
solanacearum
.
Our
research
demonstrates
that
foliar
application
this
AMP
at
concentration
200
ppm
significantly
reduces
incidence
49.3%
severity
45.8%.
Scanning
electron
microscopy
revealed
severe
morphological
disruptions
cells
upon
exposure
to
AMP.
Additionally,
enhanced
host
resistance
elevating
defense
enzyme
activities,
leading
notable
improvements
morphology,
including
95.5%
increase
length,
20.1%
biomass,
96.69%
root
length.
bifunctional
provides
dual
protection
exerting
direct
activity
against
pathogen
eliciting
mechanisms.
These
findings
underscore
potential
biologically
sourced
natural
agent
combating
diseases
promoting
growth
crops.
To
best
our
knowledge,
is
first
demonstrate
use
spray
microbial
biocontrol
R.
interaction
not
only
highlights
but
also
role
thereby
overall
agricultural
yield.
Molecules,
Год журнала:
2024,
Номер
29(20), С. 4889 - 4889
Опубликована: Окт. 15, 2024
Conventional
antibiotic
and
multidrug
treatments
are
becoming
less
effective
the
discovery
of
new
safe
antibacterial
agents
is
a
global
priority.
Returning
to
natural
product
relatively
current
trend.
Terrestrial
biota
rich
source
biologically
active
substances
whose
potential
has
not
been
fully
utilized.
The
aim
this
review
present
state-of-the-art
terrestrial
biota-derived
inspired
by
treatments.
It
summarizes
most
important
sources
newly
identified
or
modified
from
last
five
years.
focuses
on
significance
plant-
animal-
bacteria-derived
as
powerful
alternatives
antibiotics,
well
advantages
utilizing
molecules
alone
in
combination
with
antibiotics.
main
conclusion
that
products
open
variety
ways
for
modern
improved
therapeutic
strategies.
New
known
were
discovered
during
5
years,
which
under
investigation
together
some
long-ago
but
now
experiencing
their
renaissance
development
medical
use
peptides
combinational
therapy
commercial
antibiotics
outlined
promising
method
treating
bacterial
infections.
In
vivo
testing
clinical
trials
necessary
reach
application.
Journal of Peptide Science,
Год журнала:
2024,
Номер
31(2)
Опубликована: Дек. 23, 2024
ABSTRACT
Antimicrobial
peptides
(AMPs)
are
crucial
constituents
of
inherent
immunity
and
serve
as
vital
components
human
host
defense,
playing
a
pivotal
role
in
combating
invading
microbial
pathogens.
Beyond
their
antimicrobial
functions,
AMPs
also
exhibit
various
other
biological
activities
including
apoptosis
induction,
wound
healing
promotion,
immune
modulation.
These
found
exposed
tissues
or
surfaces
throughout
the
body,
such
eyes,
skin,
mouth,
ears,
respiratory
tract,
lungs,
digestive,
urinary
system.
Additionally,
certain
LL‐37,
HNP,
lactoferrin
have
shown
potential
candidates
for
anticancer
activity.
Given
limited
selectivity
between
normal
cancer
cells
exhibited
by
many
current
immunotherapeutic
agents,
properties
make
them
promising
treatment.
Their
abundance,
bioavailability,
safety
profile,
efficiency,
harmony
with
system
position
attractive
tools
fight
against
cancer.
This
review
is
aimed
at
exploring
elucidating
relationship
immunology
immunotherapy.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 25, 2024
ABSTRACT
Classically,
chemokines
coordinate
leukocyte
trafficking
during
immune
responses;
however,
many
have
also
been
reported
to
possess
direct
antibacterial
activity
in
vitro.
Yet,
the
bacterial
killing
mechanism
of
and
biochemical
properties
that
define
which
members
chemokine
superfamily
are
antimicrobial
remain
poorly
understood.
Here
we
report
is
defined
by
their
ability
bind
phosphatidylglycerol
cardiolipin,
two
anionic
phospholipids
commonly
found
plasma
membrane.
We
show
only
able
these
kill
Escherichia
coli
Staphylococcus
aureus
they
exert
rapid
bacteriostatic
bactericidal
effects
against
E.
with
a
higher
potency
than
peptide
beta-defensin
3.
Furthermore,
our
data
support
membrane
cardiolipin
facilitates
action
chemokines.
Both
genetic
interference
chemokine-cardiolipin
interaction
impaired
microbial
growth
arrest,
killing,
disruption
Moreover,
unlike
conventional
antibiotics,
failed
develop
resistance
when
placed
under
increasing
pressure
Thus,
identified
as
novel
binding
partners
for
responsible
action.
Our
results
provide
proof
principle
developing
antibiotics
resistant
mechanisms.
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 11, 2024
The
increasing
health
and
environmental
risks
associated
with
synthetic
chemical
pesticides
necessitate
the
exploration
of
safer,
sustainable
alternatives
for
plant
protection.
This
study
investigates
a
novel
biosynthesized
antimicrobial
peptide
(AMP)
from
Lactiplantibacillus
argentoratensis
strain
IT,
identified
as
amino
acid
chain
PRKGSVAKDVLPDPVYNSKLVTRLINHLMIDGKRG,
its
efficacy
in
controlling
bacterial
wilt
(BW)
disease
tomato
(
Solanum
lycopersicum
)
caused
by
Ralstonia
solanacearum
.
Our
research
demonstrates
that
foliar
application
this
AMP
at
concentration
200
ppm
significantly
reduces
incidence
49.3%
severity
45.8%.
Scanning
electron
microscopy
revealed
severe
morphological
disruptions
cells
upon
exposure
to
AMP.
Additionally,
enhanced
host
resistance
elevating
defense
enzyme
activities,
leading
notable
improvements
morphology,
including
95.5%
increase
length,
20.1%
biomass,
96.69%
root
length.
bifunctional
provides
dual
protection
exerting
direct
activity
against
pathogen
eliciting
mechanisms.
These
findings
underscore
potential
biologically
sourced
natural
agent
combating
diseases
promoting
growth
crops.
To
best
our
knowledge,
is
first
demonstrate
use
spray
microbial
biocontrol
R.
interaction
not
only
highlights
but
also
role
thereby
overall
agricultural
yield.
