Deciphering Multidrug-Resistant Pseudomonas aeruginosa: Mechanistic Insights and Environmental Risks DOI Creative Commons
Pei Yang, Péter Hamar, De‐Sheng Pei

и другие.

Toxics, Год журнала: 2025, Номер 13(4), С. 303 - 303

Опубликована: Апрель 12, 2025

The rise of multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa) presents a significant challenge to clinical treatment and environmental risks. This review delves into the complex mechanisms underlying MDR development in P. aeruginosa, such as genetic mutations, horizontal gene transfer (HGT), interaction between virulence factors resistance genes. It evaluates current detection methods, from traditional bacteriology advanced molecular techniques, emphasizing need for rapid accurate diagnostics. also examines therapeutic strategies, including broad-spectrum antibiotics, novel drug candidates, combination therapies, innovative approaches like RNA interference, CRISPR-Cas9 editing, bridge RNA-guided editing. Importantly, this highlights distribution, migration, risks underscoring its adaptability diverse environments. concludes by stressing necessity continued research antimicrobial resistance, advocating an integrated approach that combines genomics, practice, considerations devise solutions preserve antibiotic efficacy.

Язык: Английский

Discovery of quorum sensing inhibitors against Pseudomonas aeruginosa from Aspergillus sp. NB12 DOI

Xueqi Lan,

Xiaoxia Gu,

Yeting Zhang

и другие.

Bioorganic Chemistry, Год журнала: 2025, Номер 156, С. 108230 - 108230

Опубликована: Янв. 30, 2025

Язык: Английский

Процитировано

0
The Role of Immune Defense in Serratia marcescens Nosocomial Infections DOI Creative Commons
Ihsan Ali Raheem, Fatima Rammadan Abdul, Hanan Tariq Subhi

и другие.

ARO-The Scientific Journal of Koya University, Год журнала: 2025, Номер 13(1), С. 34 - 41

Опубликована: Фев. 1, 2025

Developing resistance mechanisms leads to various nosocomial infections caused by opportunistic bacteria. Serratia marcescens are well known be and equipped with an armory of virulence factors against host immune response. The study aims detect the defense in patients infected multidrug-resistant S. marcescens. includes 132 clinical samples, including burn, wound, otitis media, urinary tract infection (UTI) at several hospitals Baghdad, Iraq. All isolates identified cultivation on MacConkey agar, nutrient blood followed biochemical tests assessment VITEK 2 compact system. tested for antibiotic susceptibility tests, interleukin-12 (IL12) levels, neutrophil ability phagocytosis, complement C3 C4 levels. Out 120 positive cultures, six as urine samples most isolated source a higher level was noticed ampicillin cefotaxime (100%), whereas lower is imipenem. Stimulation (p ꞊ 0.005) provided significant increase IL-12 production. stimulated neutrophil’s phagocytosis process compared control. interplay role influences its pathogenesis, resistance, response, particularly involving neutrophils IL-12. Understanding these interactions crucial developing effective therapeutic strategies.

Язык: Английский

Процитировано

0
Comparison between the effect of gentamicin and purified Lactobacillus salivarius exopolysaccharides on the biofilm formation and Pseudomonas aeruginosa Rh1I gene expression DOI

H. Ayaat,

Ibtesam Ghadban Auda,

Likaa Hamied Mahdi

и другие.

Gene Reports, Год журнала: 2025, Номер unknown, С. 102164 - 102164

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Hybrid Molecules of Benzothiazole and Hydroxamic Acid as Dual-Acting Biofilm Inhibitors with Antibacterial Synergistic Effect against Pseudomonas aeruginosa Infections DOI

Z. Zhang,

Siyu Zhao,

Wen-Qian Liu

и другие.

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

The ubiquitous opportunistic pathogen Pseudomonas aeruginosa (P. aeruginosa) causes biofilm-associated drug-resistant infections that often lead to treatment failure. Targeting the bacterium's quorum sensing (QS) and iron homeostasis presents a promising strategy combat biofilm formation. This study synthesized benzothiazole-conjugated hydroxamic acid derivatives as dual-acting inhibitors, compound JH21 was identified hit with potent submicromolar inhibitory activity (IC50 = 0.4 μM). Further mechanistic studies demonstrated not only production of virulence decreased through mainly inhibiting QS system but also competed for high-affinity siderophore pyoverdine, inducing deficiency biofilm. Moreover, significantly enhanced efficacy tobramycin ciprofloxacin by 200- 1000-fold, respectively, in mouse wound infection model. These results emphasized feasibility inhibitors against resistant P. potential novel antibacterial synergist.

Язык: Английский

Процитировано

0
Deciphering Multidrug-Resistant Pseudomonas aeruginosa: Mechanistic Insights and Environmental Risks DOI Creative Commons
Pei Yang, Péter Hamar, De‐Sheng Pei

и другие.

Toxics, Год журнала: 2025, Номер 13(4), С. 303 - 303

Опубликована: Апрель 12, 2025

The rise of multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa) presents a significant challenge to clinical treatment and environmental risks. This review delves into the complex mechanisms underlying MDR development in P. aeruginosa, such as genetic mutations, horizontal gene transfer (HGT), interaction between virulence factors resistance genes. It evaluates current detection methods, from traditional bacteriology advanced molecular techniques, emphasizing need for rapid accurate diagnostics. also examines therapeutic strategies, including broad-spectrum antibiotics, novel drug candidates, combination therapies, innovative approaches like RNA interference, CRISPR-Cas9 editing, bridge RNA-guided editing. Importantly, this highlights distribution, migration, risks underscoring its adaptability diverse environments. concludes by stressing necessity continued research antimicrobial resistance, advocating an integrated approach that combines genomics, practice, considerations devise solutions preserve antibiotic efficacy.

Язык: Английский

Процитировано

0