Sensors,
Год журнала:
2023,
Номер
23(23), С. 9508 - 9508
Опубликована: Ноя. 29, 2023
In
the
present
work,
potentiometric
sensors
with
polymer
membranes
used
for
chlorhexidine
(CHXD)
determination
were
developed.
The
plasticized
bis(2-ethylheksyl)sebacate
(DOS)
or
2-nitrophenyloctyl
ether
(o-NPOE).
active
compounds
in
membrane
cyclodextrins,
crown
ethers,
and
ion
exchangers.
best-constructed
electrode
was
based
on
neutral
heptakis(2,3,6-tri-O-benzoyl)-β-cyclodextrin
lipophilic
salt
(KTpClBP)—potassium
tetrakis(4-chlorophenyl)
borate—dissolved
plasticizer,
DOS.
presented
is
characterized
by
an
average
cationic
slope
of
30.9
±
2.9
mV
decade−1
within
a
linear
range
1
×
10−6
to
10−3
mol
L−1,
while
value
correlation
coefficient
0.9970
0.0026.
response
time
about
5
s
when
increasing
sample
concentration
10
diluting
sample.
potential
independent
pH
4.0–9.5.
polymeric
sensor
successfully
applied
assays
digluconate
pure
samples
pharmaceutical
samples.
relative
error
from
three
replicate
measurements
determined
be
1.1%.
accuracy
RSD
=
0.3–1.1%.
RSC Advances,
Год журнала:
2024,
Номер
14(22), С. 15232 - 15239
Опубликована: Янв. 1, 2024
The
paper
discusses
the
synthesis
and
catalytic
activity
of
a
promising,
cost-effective,
stable
Prussian
blue
analogue
nanocatalyst
for
rapid
elimination
hazardous
azo
dye
in
industrial
effluents.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июль 16, 2024
Abstract
A
novel,
highly
sensitive
and
eco-friendly
micellar-mediated
spectrofluorimetric
method
was
developed
validated
for
the
determination
of
novel
antiparkinsonian
drug
safinamide
mesylate
in
presence
its
related
precursor
impurity,
4-hydroxybenzaldehyde.
The
proposed
approach
relies
on
increasing
inherent
fluorescence
emission
at
296
nm
safinamide,
by
forming
hydrogen
bonds
between
mentioned
sodium
dodecyl
sulfate
micellar
system
using
0.1
N
HCl
as
a
solvent,
following
excitation
226
nm.
thorough
investigation
conducted
into
experimental
factors
affecting
behavior
studied
drug.
linearity
plot
over
concentration
range
10.0–1000.0
ng/mL
against
relative
intensities
established.
demonstrated
excellent
sensitivity
down
to
nano-gram
level
with
detection
quantitation
limits
1.91
5.79
ng/mL,
respectively.
effectively
determined
Parkimedine
®
Tablets.
Furthermore,
allows
ultrasensitive
quantification
spiked
human
plasma,
satisfactory
percentage
recovery
(98.97–102.28%).
Additionally,
greenness
assessment
advanced
green
certificate
classification
approach,
complementary
analytical
procedure
index
(Complex-GAPI),
GREEness
metric
(AGREE),
along
practicality
check
Blue
Applicability
Grade
Index
addition
all-inclusive
overall
whiteness
evaluation
RGB-12
model
were
carried
out.
outcomes
effectiveness
technique.
Clearly,
suggested
has
advantages
being
simple,
requiring
no
pretreatment
steps,
relying
solely
direct
measuring
procedures.
Parkinson's
disease
(PD)
emerges
as
a
notable
health
concern
among
the
elderly
population.
Safinamide
mesylate
(SAF)
is
novel
and
emerging
add-on
therapy
in
PD
treatment.
The
stability
of
innovative
drug
formulations
development
appropriate
stability-indicating
methods
are
great
importance
to
modern
pharmaceutical
analysis.
current
work
has
established
comprehensive
chromatographic
approaches,
HPTLC
coupled
with
densitometric
quantification
HPLC-DAD,
for
selective
assay
SAF
formulation
along
its
synthetic
precursor
impurity;
4-hydroxy
benzaldehyde
(4-HBD)
presence
stress
induced
degradation
products.
was
investigated
under
different
conditions.
It
found
that
likely
undergo
acid,
base
hydrolysis,
oxidative
degradation.
Using
mass
spectrometry
infrared
spectroscopy,
structures
forced
products
were
confirmed
elucidated.
dissolution
behavior
Parkimedine
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 6, 2025
Abstract
In
recent
times,
a
truly
exquisite
pharmaceutical
marvel
has
graced
the
world
of
medicine,
known
as
Safinamide
(SAF).
This
opulent
creation
been
specifically
tailored
to
cater
needs
individuals
afflicted
with
Parkinson’s
disease
(PD),
an
esteemed
neurological
condition
renowned
for
its
regal
ability
impede
motor
skills,
coordination,
and
equilibrium.
It
is
highly
improbable
that
degradation
products
components
would
significantly
compromise
efficiency
safety
drug
during
shelf
life.
Pharmaceutical
analysis
requires
variety
stability
tests
be
conducted
under
distinct
conditions.
As
result,
there
was
increased
need
development
analytical
methodology
capable
reliably
separating
quantifying
degradants
impurities
might
found
in
pharmaceuticals.
this
study,
we
have
developed
two
efficient
straightforward
spectrophotometric
methodologies
concurrent
estimation
SAF
product
(SAF
DEG),
which
main
acid
hydrolysis
product.
The
confirmation
build-up
by
use
several
techniques,
including
infrared
spectroscopy
(IR),
mass
spectrometry
(MS)
investigations.
present
validated
linearity
within
concentration
range
5–30
µg/ml
SAF,
5–15
µg/mL,
2–15
DEG
fourier
self-deconvolution
(FSD)
dual
wavelength
(DW)
methods,
respectively.
originality
these
techniques
lies
their
status
first
stability-indicating
procedures
are
both
environmentally
friendly.
Moreover,
process
obtaining
pure
offers
substantial
economic
benefits
obviating
acquire
costly
constituent.
intelligent
employed
analyze
dosage
form,
potentially
offering
significant
advantages
industry.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 27, 2025
Abstract
Mirabegron
and
tamsulosin
have
recently
been
prescribed
to
men
with
overactive
bladder
for
the
treatment
of
benign
prostatic
hypertrophy.
An
efficient
environmentally
friendly
HPLC
method
was
developed
accurately
measure
levels
mirabegron
in
both
their
pure
form
medication
formulations.
Full
separation
achieved
on
an
X-Bridge
C18
column
using
a
gradient
elution
(The
A
mobile
phase
buffer
solution
containing
1
mL
trifluoroacetic
acid
3
triethylamine
1,000
milliliters
water,
pH
then
adjusted
B-mobile
acetonitrile).
The
chromatographic
peaks
were
obtained
at
wavelength
220
nm.
identified
retention
time
values
2.4
min
8.9
min,
respectively.
In
concentration
ranges
2.5–55
µg/mL
5–110
tamsulosin,
remarkable
linearity
seen.
limits
detection
two
analytes
0.28
0.55
µg/mL,
respectively,
R
2
0.9999.
new
evaluated
its
environmental
friendliness
Analytical
GREEness
(AGREE)
metric.
Furthermore,
suggested
technique
considered
practicable
based
evaluation
conducted
Blue
Applicability
Grade
Index
(BAGI)
assessment.
Both
methods
quite
successful,
yielding
scores
0.52
80,
Compared
TLC-reported
method,
is
preferred
choice
due
sensitivity.
RSC Advances,
Год журнала:
2023,
Номер
13(36), С. 25129 - 25139
Опубликована: Янв. 1, 2023
The
electropolymerized
molecularly
imprinted
polymers
(MIP)
have
enabled
the
utilization
of
various
functional
monomers
with
superior
selective
recognition
target
analyte
template.
Methyldopa
is
an
attractive
synthetic
dopamine
analogue
which
has
phenolic,
carboxylic,
and
aminic
groups.
In
this
research,
methyldopa
was
exploited
to
fabricate
MIPs,
for
detection
sofosbuvir
(SFB),
by
a
simple
electropolymerization
step
onto
disposable
pencil
graphite
electrode
(PGE)
substrate.
interaction
between
methyldopa,
as
monomer,
template
been
investigated
experimentally
UV
spectroscopy.
A
polymethyldopa
(PMD)
polymer
electrografted
PGE
in
presence
SFB
X-ray
photoelectron
spectroscopy
(XPS),
electrochemical
impedance
(ESI),
cyclic
voltammetry
(CV)
were
used
characterization
fabricated
sensor.
Differential
pulse
(DPV)
ferrocyanide/ferricyanide
redox
probe
employed
indirectly
detect
binding
MIP
cavities.
sensor
shows
reproducible
linear
response
over
dynamic
range
from
1.0
×
10-11
M
10-13
limit
3.1
10-14
M.
showed
high
selectivity
drug
structurally
similar
co-administered
interfering
drugs,
its
application
pharmaceutical
dosage
form
spiked
human
plasma
samples.
