The
advancement
of
chromatographic
separations
is
fundamentally
tied
to
the
development
innovative
stationary
phases.
This
study
introduces
first
use
spherical
hypercrosslinked
polymers
(HCPs),
Poly-BINOL,
synthesized
through
a
knitting
strategy
employing
binaphthol,
as
novel
phase
for
HPLC
targeting
mixed-mode
separations.
Poly-BINOL
demonstrates
exceptional
chemical
and
mechanical
stability,
broad
pH
resilience,
superior
solvent
resistance,
along
with
an
expanded
specific
surface
area
conducive
efficient
separation
small
molecules.
characterization
BET,
SEM,
FT-IR
spectroscopy,
thermal
stability
assessments
highlights
its
distinct
physical
properties.
efficacy
packed
columns
was
showcased
various
analytes
under
diverse
operational
conditions,
exhibiting
unparalleled
selectivity
efficiency.
Notably,
it
showed
superiority
in
separating
complex
samples
enhanced
retention
capabilities
PAHs
due
pronounced
π-π
interactions.
Analytical
performance
evaluations
confirmed
high
reproducibility
separations,
especially
precise
selective
analysis
PAH
compounds.
groundbreaking
work
not
only
potential
HCPs
liquid
chromatography
but
also
opens
avenues
future
research
application
broader
field
science.
