Disposable Face Masks for Noninvasive Drug Detection: A Proof-of-Concept Study with Cough Syrup Constituents

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

Current drug detection methods, such as blood and urine analysis, are often invasive raise ethical privacy concerns. This study demonstrates that breathing through typical polypropylene-based meltblown cloth face masks is an efficient user-friendly method for collecting drugs from exhaled breath analysis. By using codeine, ephedrine, guaifenesin, chlorpheniramine found in cough syrup model compounds, we these achieved a collection efficiency exceeding 92% the tested drugs. The analysis yielded pharmacokinetic parameters─such half-life (t1/2), time to maximum concentration (Tmax), window─that were comparable those obtained parallel Given increasing demand noninvasive methods due rising abuse of substances like marijuana fentanyl, this expected have broad applications forensic development.

Язык: Английский

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A new kind of polystyrene/polyethyleneimine nanofibres coordinated with palladium for fast and efficient extraction of methotrexate and its polyglutamate metabolites in different matrices

RSC Advances, Год журнала: 2025, Номер 15(19), С. 15017 - 15028

Опубликована: Янв. 1, 2025

Conceptual framework of the current study.

Язык: Английский

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Hg2+ crosslinked two-dimensional photonic crystal hydrogel sensor for the “off–on” detection of iodine ion

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113996 - 113996

Опубликована: Май 1, 2025

Язык: Английский

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Simultaneous Determination of Glibenclamide, Metoprolol Tartrate, and Phenol Red Using HPLC‐PDA: Application in Rat Intestinal Permeability Studies and Its Greenness Assessment Using NEMI, Analytical Eco‐Scale, GAPI, MoGAPI, AGREE, AGREEprep, RAPI, BAGI, and CACI

Biomedical Chromatography, Год журнала: 2025, Номер 39(7)

Опубликована: Май 28, 2025

ABSTRACT This study presents the development and validation of an environmentally friendly HPLC‐PDA method for simultaneous determination glibenclamide (GLB), metoprolol tartrate (MET), phenol red (PR). The was optimized to ensure high trueness, precision, robustness, adhering ICH guidelines. pKa GLB determined using reverse‐phase HPLC under varying pH conditions, providing valuable insights into its physicochemical properties enhancing pharmaceutical formulation potential. Intestinal permeability studies GLB, conducted via in situ Single Pass Perfusion (SPIP) technique, validated method's applicability biological systems. In addition analytical performance, environmental sustainability assessed green metrics, including Analytical Eco‐Scale, GAPI, MoGAPI, AGREE, AGREEprep RAPI, BAGI, CACI. achieved scores, reflecting alignment with principles chemistry minimal ecological impact. dual focus on rigor responsibility emphasizes potential broader applications biomedical research. findings this contribute ongoing efforts developing sustainable methodologies. Future research could explore other compounds expand use complex matrices, further promoting conscious practices chemistry.

Язык: Английский

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Nanozyme Biosensors: Catalytic Mechanism, Activity Regulation, Signal Amplification and Application in Food Analysis

Talanta, Год журнала: 2025, Номер 296, С. 128398 - 128398

Опубликована: Май 28, 2025

Язык: Английский

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Synthesis and use of new magnetic adsorbent for sensitive, practical and simultaneous analysis Ibuprofen and Ketoprofen molecules in urine samples

Journal of Chromatography B, Год журнала: 2024, Номер 1251, С. 124404 - 124404

Опубликована: Дек. 10, 2024

Язык: Английский

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