A Gold Nanoparticles and MXene Nanocomposite Based Electrochemical Sensor for Point-of-Care Monitoring of Serum Biomarkers DOI
Yongmei Chen, Xinyu Zhang, Yan Liu

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

The development of portable, cost-effective, and highly sensitive biosensors for real-time biomarker detection is crucial advancing point-of-care testing (POCT) wearable health monitoring. Here, we present an integrated portable electrochemical sensor (ip-ECS) that combines gold nanoparticles (AuNPs) MXene-modified screen-printed electrodes (SPEs) with a custom-designed, low-power electronic system monitoring serum biomarkers. AuNPs MXene nanocomposite significantly enhances the performance SPE by providing high density active sites, improved conductivity, catalytic activity. two model molecules (DA UA) validated feasibility ip-ECS, achieving limits as low 1.12 1.11 μM UA DA, respectively. Furthermore, ip-ECS was successfully applied to detect Cys C in human serum, showing linear response range 50-5000 ng/mL strong correlation (ρ = 0.9556) conventional latex immunoturbidimetry (LIA). Clinical validation using samples from pregnant women revealed elevated levels gestational diabetes mellitus (GDM) patients, highlighting sensor's potential early GDM risk prediction. represents significant step forward next-generation POCT, diagnostics, personalized medicine.

Язык: Английский

Biorecognition-based electrochemical sensors for highly sensitive C-reactive protein detection: A review DOI
Adil Mehmood Khan, Muhammad Khairil Anwar, Atiq Ur Rehman

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140829 - 140829

Опубликована: Фев. 10, 2025

Язык: Английский

Процитировано

0
Insights into vertically aligned carbon nanofiber (VACNF) (bio)electrodes and their application potential – An overview DOI Creative Commons
Tomi Laurila

Diamond and Related Materials, Год журнала: 2025, Номер unknown, С. 112261 - 112261

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
An electrochemical sensor for dopamine on a graphene-poly(3,4-ethylenedioxythiophene):polystyrene sulphonate hybrid ink nanoplatform DOI Creative Commons

Sesethu Makaluza,

Nyasha Midzi,

Foluke O. G. Olorundare

и другие.

Deleted Journal, Год журнала: 2025, Номер 7(4)

Опубликована: Апрель 1, 2025

Abstract Dopamine can be used as a biomarker for diseases such Alzheimer’s, bipolar disorder, schizophrenia, mania, to mention few, well addiction tobacco. Thus, its measurement is of biomedical importance. We present an easy-to-construct, one-step, electrochemical sensor dopamine based on drop coating commercial graphene/poly (3,4-ethylenedioxythiophene):polystyrene sulphonate (Gr-PEDOT:PSS) hybrid ink dispersion bare glassy carbon electrode surface. The conductive polymer’s structural properties and composition were explored using XRD, Raman, FTIR spectroscopy electron microscopy. nanocomposite exhibited uniform size distribution functional groups aromatic, thiol, olefinic bonds improved the surface chemistry between electrolyte/analyte electrode. Characterization through impedance voltammetry demonstrated that Gr-PEDOT:PSS significantly enhances transfer kinetics at therefore improve electrooxidation dopamine. achieved detection limit 0.19 µM within linear concentration range 3.13–400 It also high selectivity against potential interfering agents like ascorbic acid, caffeine, urea, with recovery percentages ranging from 105 109% in human serum samples.

Язык: Английский

Процитировано

0
A Gold Nanoparticles and MXene Nanocomposite Based Electrochemical Sensor for Point-of-Care Monitoring of Serum Biomarkers DOI
Yongmei Chen, Xinyu Zhang, Yan Liu

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

The development of portable, cost-effective, and highly sensitive biosensors for real-time biomarker detection is crucial advancing point-of-care testing (POCT) wearable health monitoring. Here, we present an integrated portable electrochemical sensor (ip-ECS) that combines gold nanoparticles (AuNPs) MXene-modified screen-printed electrodes (SPEs) with a custom-designed, low-power electronic system monitoring serum biomarkers. AuNPs MXene nanocomposite significantly enhances the performance SPE by providing high density active sites, improved conductivity, catalytic activity. two model molecules (DA UA) validated feasibility ip-ECS, achieving limits as low 1.12 1.11 μM UA DA, respectively. Furthermore, ip-ECS was successfully applied to detect Cys C in human serum, showing linear response range 50-5000 ng/mL strong correlation (ρ = 0.9556) conventional latex immunoturbidimetry (LIA). Clinical validation using samples from pregnant women revealed elevated levels gestational diabetes mellitus (GDM) patients, highlighting sensor's potential early GDM risk prediction. represents significant step forward next-generation POCT, diagnostics, personalized medicine.

Язык: Английский

Процитировано

0